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Gene: HAX1 |
Gene summary for HAX1 |
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Gene information | Species | Human | Gene symbol | HAX1 | Gene ID | 10456 |
Gene name | HCLS1 associated protein X-1 | |
Gene Alias | HCLSBP1 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000422 | UniProtAcc | A0A0S2Z565 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10456 | HAX1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.86e-02 | 1.95e-01 | -0.1808 |
10456 | HAX1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.75e-04 | 3.95e-01 | 0.0216 |
10456 | HAX1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.41e-09 | 3.95e-01 | -0.0811 |
10456 | HAX1 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.86e-03 | 1.52e-01 | -0.1088 |
10456 | HAX1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.07e-15 | 3.54e-01 | -0.1954 |
10456 | HAX1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.32e-04 | 4.87e-01 | -0.2196 |
10456 | HAX1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.97e-05 | 2.42e-01 | -0.1207 |
10456 | HAX1 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.79e-04 | 3.13e-01 | -0.1526 |
10456 | HAX1 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.31e-18 | 4.11e-01 | -0.1464 |
10456 | HAX1 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.52e-05 | 2.25e-01 | -0.1001 |
10456 | HAX1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.72e-16 | 5.37e-01 | -0.059 |
10456 | HAX1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.08e-05 | 3.76e-01 | -0.1706 |
10456 | HAX1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.54e-03 | 3.95e-01 | -0.1462 |
10456 | HAX1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.68e-06 | 3.01e-01 | -0.0842 |
10456 | HAX1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.24e-02 | 2.85e-01 | -0.00410000000000005 |
10456 | HAX1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.05e-02 | 2.59e-01 | -0.0179 |
10456 | HAX1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.13e-16 | 4.31e-01 | 0.096 |
10456 | HAX1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.69e-03 | 3.43e-01 | 0.0446 |
10456 | HAX1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.55e-05 | 2.12e-01 | 0.0338 |
10456 | HAX1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.81e-11 | 3.15e-01 | 0.0674 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HAX1 | SNV | Missense_Mutation | novel | c.511N>A | p.Asp171Asn | p.D171N | O00165 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
HAX1 | SNV | Missense_Mutation | novel | c.775C>G | p.Pro259Ala | p.P259A | O00165 | protein_coding | deleterious(0.04) | possibly_damaging(0.561) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
HAX1 | insertion | Nonsense_Mutation | novel | c.492_493insACTATGGAAATTCTAATTCCCTCCCAGTCCAGCTAGCATACAA | p.Pro165ThrfsTer12 | p.P165Tfs*12 | O00165 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
HAX1 | insertion | Frame_Shift_Ins | novel | c.173dupC | p.Glu59Ter | p.E59* | O00165 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HAX1 | SNV | Missense_Mutation | c.64N>T | p.Pro22Ser | p.P22S | O00165 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
HAX1 | SNV | Missense_Mutation | rs769438062 | c.196N>G | p.Ser66Gly | p.S66G | O00165 | protein_coding | tolerated(0.13) | benign(0) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
HAX1 | SNV | Missense_Mutation | c.827N>C | p.Phe276Ser | p.F276S | O00165 | protein_coding | deleterious(0.04) | benign(0.094) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HAX1 | SNV | Missense_Mutation | novel | c.259N>T | p.Asp87Tyr | p.D87Y | O00165 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
HAX1 | SNV | Missense_Mutation | novel | c.560T>C | p.Leu187Pro | p.L187P | O00165 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3IA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HAX1 | SNV | Missense_Mutation | c.289N>A | p.Ala97Thr | p.A97T | O00165 | protein_coding | tolerated(0.28) | possibly_damaging(0.651) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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