Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: HAND2

Gene summary for HAND2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

HAND2

Gene ID

9464

Gene nameheart and neural crest derivatives expressed 2
Gene AliasDHAND2
Cytomap4q34.1
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

P61296


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
9464HAND2P11T-EHumanEsophagusESCC9.07e-041.93e-010.1426
9464HAND2P16T-EHumanEsophagusESCC5.17e-275.02e-010.1153
9464HAND2P56T-EHumanEsophagusESCC5.84e-109.18e-010.1613
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0051098111EsophagusESCCregulation of binding251/8552363/187236.73e-208.46e-18251
GO:000170119EsophagusESCCin utero embryonic development243/8552367/187231.00e-156.86e-14243
GO:0048732111EsophagusESCCgland development269/8552436/187237.81e-122.95e-10269
GO:0051099111EsophagusESCCpositive regulation of binding122/8552173/187232.79e-119.45e-10122
GO:0051101111EsophagusESCCregulation of DNA binding84/8552118/187231.64e-083.21e-0784
GO:0051100111EsophagusESCCnegative regulation of binding109/8552162/187232.10e-084.03e-07109
GO:003109818EsophagusESCCstress-activated protein kinase signaling cascade154/8552247/187238.53e-081.44e-06154
GO:00510908EsophagusESCCregulation of DNA-binding transcription factor activity252/8552440/187235.22e-076.97e-06252
GO:005140318EsophagusESCCstress-activated MAPK cascade147/8552239/187235.43e-077.18e-06147
GO:000164918EsophagusESCCosteoblast differentiation140/8552229/187231.63e-061.95e-05140
GO:000150317EsophagusESCCossification232/8552408/187233.00e-063.40e-05232
GO:006056210EsophagusESCCepithelial tube morphogenesis187/8552325/187239.95e-069.44e-05187
GO:007030217EsophagusESCCregulation of stress-activated protein kinase signaling cascade119/8552195/187231.07e-051.01e-04119
GO:003287217EsophagusESCCregulation of stress-activated MAPK cascade116/8552192/187232.63e-052.21e-04116
GO:00488638EsophagusESCCstem cell differentiation122/8552206/187235.95e-054.59e-04122
GO:00485386EsophagusESCCthymus development33/855245/187231.54e-041.02e-0333
GO:00433924EsophagusESCCnegative regulation of DNA binding37/855252/187231.75e-041.14e-0337
GO:00487628EsophagusESCCmesenchymal cell differentiation133/8552236/187235.94e-043.22e-03133
GO:004338819EsophagusESCCpositive regulation of DNA binding38/855256/187236.60e-043.50e-0338
GO:00485687EsophagusESCCembryonic organ development228/8552427/187237.28e-043.79e-03228
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
HAND2ECMSkinADJCTD-3252C9.4,C1QTNF2,GLIS2, etc.1.49e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HAND2INCAFSkincSCCCTD-3252C9.4,C1QTNF2,GLIS2, etc.2.75e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HAND2SMCStomachADJSYNM,SNX7,FAS, etc.1.26e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HAND2SMCStomachSIMSYNM,SNX7,FAS, etc.1.05e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HAND2ECMThyroidHealthyANGPTL1,ABCA8,CFH, etc.4.73e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HAND2ECMThyroidHTANGPTL1,ABCA8,CFH, etc.5.46e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
HAND2SNVMissense_Mutationc.508N>Ap.Glu170Lysp.E170KP61296protein_codingdeleterious(0)possibly_damaging(0.488)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
HAND2SNVMissense_Mutationrs776061276c.504N>Tp.Lys168Asnp.K168NP61296protein_codingdeleterious(0.02)possibly_damaging(0.694)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
HAND2SNVMissense_Mutationc.339N>Tp.Gln113Hisp.Q113HP61296protein_codingtolerated(0.05)probably_damaging(0.99)TCGA-AQ-A04H-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapytaxotereSD
HAND2SNVMissense_Mutationc.540G>Cp.Lys180Asnp.K180NP61296protein_codingdeleterious(0.03)benign(0.007)TCGA-BH-A2L8-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanCR
HAND2SNVMissense_Mutationc.311C>Ap.Ala104Aspp.A104DP61296protein_codingdeleterious(0.01)probably_damaging(0.988)TCGA-C8-A12P-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
HAND2SNVMissense_Mutationc.540G>Cp.Lys180Asnp.K180NP61296protein_codingdeleterious(0.03)benign(0.007)TCGA-C8-A1HM-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapydoxorubicinCR
HAND2insertionNonsense_Mutationnovelc.355_356insCGAAAACGGGCGGTTGTTTATAAACTTGTGGATCCGGTTGTTGAGp.Phe119delinsSerLysThrGlyGlyCysLeuTerThrCysGlySerGlyCysTerValp.F119delinsSKTGGCL*TCGSGC*VP61296protein_codingTCGA-A8-A0AB-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
HAND2insertionNonsense_Mutationnovelc.347_348insGTGAGGAGGAGGAGAAGGAGGAGGAGGAGAGCGCGAGTGAGCAGGGGp.Asn116LysfsTer2p.N116Kfs*2P61296protein_codingTCGA-AO-A0JB-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamideSD
HAND2SNVMissense_Mutationc.608G>Ap.Arg203Glnp.R203QP61296protein_codingdeleterious(0)probably_damaging(0.999)TCGA-EI-7004-01Colorectumrectum adenocarcinomaFemale<65III/IVChemotherapyxelodaSD
HAND2SNVMissense_Mutationnovelc.491C>Tp.Ala164Valp.A164VP61296protein_codingtolerated(0.19)benign(0.03)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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