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Gene: HAGHL |
Gene summary for HAGHL |
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Gene information | Species | Human | Gene symbol | HAGHL | Gene ID | 84264 |
Gene name | hydroxyacylglutathione hydrolase like | |
Gene Alias | HAGHL | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q6PII5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84264 | HAGHL | LZE24T | Human | Esophagus | ESCC | 6.29e-04 | 1.81e-01 | 0.0596 |
84264 | HAGHL | P1T-E | Human | Esophagus | ESCC | 7.11e-04 | 1.81e-01 | 0.0875 |
84264 | HAGHL | P4T-E | Human | Esophagus | ESCC | 1.17e-15 | 3.77e-01 | 0.1323 |
84264 | HAGHL | P5T-E | Human | Esophagus | ESCC | 1.02e-31 | 5.70e-01 | 0.1327 |
84264 | HAGHL | P9T-E | Human | Esophagus | ESCC | 1.11e-03 | 1.25e-01 | 0.1131 |
84264 | HAGHL | P11T-E | Human | Esophagus | ESCC | 1.13e-06 | 2.48e-01 | 0.1426 |
84264 | HAGHL | P12T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.67e-01 | 0.1122 |
84264 | HAGHL | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.07e-01 | 0.1149 |
84264 | HAGHL | P16T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.53e-01 | 0.1153 |
84264 | HAGHL | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 3.41e-01 | 0.1662 |
84264 | HAGHL | P20T-E | Human | Esophagus | ESCC | 8.24e-04 | 1.55e-01 | 0.1124 |
84264 | HAGHL | P21T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.89e-01 | 0.1617 |
84264 | HAGHL | P22T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.70e-01 | 0.1236 |
84264 | HAGHL | P26T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.68e-01 | 0.1276 |
84264 | HAGHL | P27T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.60e-01 | 0.1055 |
84264 | HAGHL | P28T-E | Human | Esophagus | ESCC | 5.30e-21 | 3.84e-01 | 0.1149 |
84264 | HAGHL | P30T-E | Human | Esophagus | ESCC | 1.89e-05 | 2.77e-01 | 0.137 |
84264 | HAGHL | P31T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.86e-01 | 0.1251 |
84264 | HAGHL | P32T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.96e-01 | 0.1666 |
84264 | HAGHL | P37T-E | Human | Esophagus | ESCC | 4.58e-09 | 1.90e-01 | 0.1371 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HAGHL | SNV | Missense_Mutation | novel | c.70N>C | p.Glu24Gln | p.E24Q | Q6PII5 | protein_coding | tolerated(0.15) | benign(0.129) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
HAGHL | deletion | Frame_Shift_Del | novel | c.21delC | p.Val8CysfsTer40 | p.V8Cfs*40 | Q6PII5 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
HAGHL | SNV | Missense_Mutation | c.626N>T | p.Thr209Ile | p.T209I | Q6PII5 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-A6-A566-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | PD | |
HAGHL | SNV | Missense_Mutation | c.88N>A | p.Val30Met | p.V30M | Q6PII5 | protein_coding | deleterious(0.01) | possibly_damaging(0.754) | TCGA-AZ-6600-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cpt-11 | PD | |
HAGHL | SNV | Missense_Mutation | novel | c.89N>G | p.Val30Gly | p.V30G | Q6PII5 | protein_coding | deleterious(0.01) | benign(0.173) | TCGA-AZ-6600-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cpt-11 | PD |
HAGHL | SNV | Missense_Mutation | c.580G>T | p.Ala194Ser | p.A194S | Q6PII5 | protein_coding | tolerated(0.18) | benign(0.173) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HAGHL | SNV | Missense_Mutation | novel | c.35A>G | p.Asn12Ser | p.N12S | Q6PII5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HAGHL | SNV | Missense_Mutation | novel | c.550N>G | p.Lys184Glu | p.K184E | Q6PII5 | protein_coding | tolerated(0.17) | possibly_damaging(0.852) | TCGA-2Y-A9HA-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
HAGHL | SNV | Missense_Mutation | c.50T>G | p.Val17Gly | p.V17G | Q6PII5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-FV-A495-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HAGHL | SNV | Missense_Mutation | novel | c.70N>A | p.Glu24Lys | p.E24K | Q6PII5 | protein_coding | tolerated(0.11) | benign(0.355) | TCGA-05-5715-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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