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Gene: HACD1 |
Gene summary for HACD1 |
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Gene information | Species | Human | Gene symbol | HACD1 | Gene ID | 9200 |
Gene name | 3-hydroxyacyl-CoA dehydratase 1 | |
Gene Alias | CAP | |
Cytomap | 10p12.33 | |
Gene Type | protein-coding | GO ID | GO:0000038 | UniProtAcc | B0YJ81 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9200 | HACD1 | LZE4T | Human | Esophagus | ESCC | 5.25e-03 | 1.03e-01 | 0.0811 |
9200 | HACD1 | P2T-E | Human | Esophagus | ESCC | 7.76e-10 | 2.66e-01 | 0.1177 |
9200 | HACD1 | P4T-E | Human | Esophagus | ESCC | 3.02e-09 | 3.99e-01 | 0.1323 |
9200 | HACD1 | P5T-E | Human | Esophagus | ESCC | 2.28e-19 | 5.30e-01 | 0.1327 |
9200 | HACD1 | P11T-E | Human | Esophagus | ESCC | 4.73e-03 | 2.59e-01 | 0.1426 |
9200 | HACD1 | P15T-E | Human | Esophagus | ESCC | 1.75e-09 | 3.70e-01 | 0.1149 |
9200 | HACD1 | P16T-E | Human | Esophagus | ESCC | 1.41e-08 | 3.07e-01 | 0.1153 |
9200 | HACD1 | P19T-E | Human | Esophagus | ESCC | 1.68e-03 | 5.49e-01 | 0.1662 |
9200 | HACD1 | P21T-E | Human | Esophagus | ESCC | 6.15e-36 | 1.02e+00 | 0.1617 |
9200 | HACD1 | P22T-E | Human | Esophagus | ESCC | 4.11e-05 | 1.28e-01 | 0.1236 |
9200 | HACD1 | P24T-E | Human | Esophagus | ESCC | 3.32e-07 | 1.00e-01 | 0.1287 |
9200 | HACD1 | P26T-E | Human | Esophagus | ESCC | 2.76e-15 | 3.88e-01 | 0.1276 |
9200 | HACD1 | P27T-E | Human | Esophagus | ESCC | 7.92e-06 | 2.92e-01 | 0.1055 |
9200 | HACD1 | P30T-E | Human | Esophagus | ESCC | 2.64e-03 | 2.44e-01 | 0.137 |
9200 | HACD1 | P31T-E | Human | Esophagus | ESCC | 2.23e-12 | 3.52e-01 | 0.1251 |
9200 | HACD1 | P32T-E | Human | Esophagus | ESCC | 1.26e-11 | 3.12e-01 | 0.1666 |
9200 | HACD1 | P37T-E | Human | Esophagus | ESCC | 4.30e-12 | 4.61e-01 | 0.1371 |
9200 | HACD1 | P39T-E | Human | Esophagus | ESCC | 3.86e-10 | 8.11e-02 | 0.0894 |
9200 | HACD1 | P40T-E | Human | Esophagus | ESCC | 4.34e-04 | 1.83e-01 | 0.109 |
9200 | HACD1 | P42T-E | Human | Esophagus | ESCC | 5.54e-03 | 2.17e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:00066433 | Esophagus | ESCC | membrane lipid metabolic process | 130/8552 | 203/18723 | 9.29e-08 | 1.54e-06 | 130 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:0009259111 | Esophagus | ESCC | ribonucleotide metabolic process | 224/8552 | 385/18723 | 4.41e-07 | 6.00e-06 | 224 |
GO:0072521111 | Esophagus | ESCC | purine-containing compound metabolic process | 238/8552 | 416/18723 | 1.20e-06 | 1.49e-05 | 238 |
GO:0009150111 | Esophagus | ESCC | purine ribonucleotide metabolic process | 213/8552 | 368/18723 | 1.40e-06 | 1.69e-05 | 213 |
GO:0046390110 | Esophagus | ESCC | ribose phosphate biosynthetic process | 119/8552 | 190/18723 | 1.73e-06 | 2.06e-05 | 119 |
GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:0006163111 | Esophagus | ESCC | purine nucleotide metabolic process | 226/8552 | 396/18723 | 2.81e-06 | 3.21e-05 | 226 |
GO:00464673 | Esophagus | ESCC | membrane lipid biosynthetic process | 91/8552 | 142/18723 | 7.19e-06 | 7.19e-05 | 91 |
GO:000916516 | Esophagus | ESCC | nucleotide biosynthetic process | 150/8552 | 254/18723 | 1.12e-05 | 1.06e-04 | 150 |
GO:0009260110 | Esophagus | ESCC | ribonucleotide biosynthetic process | 112/8552 | 182/18723 | 1.12e-05 | 1.06e-04 | 112 |
GO:190129316 | Esophagus | ESCC | nucleoside phosphate biosynthetic process | 151/8552 | 256/18723 | 1.15e-05 | 1.08e-04 | 151 |
GO:00338664 | Esophagus | ESCC | nucleoside bisphosphate biosynthetic process | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:00340304 | Esophagus | ESCC | ribonucleoside bisphosphate biosynthetic process | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:00340334 | Esophagus | ESCC | purine nucleoside bisphosphate biosynthetic process | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:007252217 | Esophagus | ESCC | purine-containing compound biosynthetic process | 120/8552 | 200/18723 | 3.02e-05 | 2.51e-04 | 120 |
GO:00066652 | Esophagus | ESCC | sphingolipid metabolic process | 96/8552 | 155/18723 | 3.21e-05 | 2.66e-04 | 96 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012129 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa0121214 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa012128 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
hsa0121213 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HACD1 | SNV | Missense_Mutation | novel | c.286C>G | p.Arg96Gly | p.R96G | B0YJ81 | protein_coding | tolerated(0.06) | benign(0.017) | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
HACD1 | SNV | Missense_Mutation | c.495N>C | p.Glu165Asp | p.E165D | B0YJ81 | protein_coding | deleterious(0.02) | benign(0.044) | TCGA-B6-A0RQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HACD1 | SNV | Missense_Mutation | c.373N>C | p.Glu125Gln | p.E125Q | B0YJ81 | protein_coding | deleterious(0.02) | probably_damaging(0.957) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
HACD1 | SNV | Missense_Mutation | c.611N>T | p.Asn204Ile | p.N204I | B0YJ81 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HACD1 | SNV | Missense_Mutation | c.508N>T | p.Leu170Phe | p.L170F | B0YJ81 | protein_coding | deleterious(0) | benign(0.314) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HACD1 | SNV | Missense_Mutation | novel | c.305G>A | p.Gly102Glu | p.G102E | B0YJ81 | protein_coding | deleterious(0.01) | benign(0.075) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HACD1 | deletion | Frame_Shift_Del | c.618delN | p.Phe206LeufsTer23 | p.F206Lfs*23 | B0YJ81 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
HACD1 | SNV | Missense_Mutation | c.815N>A | p.Arg272His | p.R272H | B0YJ81 | protein_coding | tolerated(0.32) | benign(0.17) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
HACD1 | SNV | Missense_Mutation | rs782115025 | c.667N>A | p.Ala223Thr | p.A223T | B0YJ81 | protein_coding | deleterious(0.04) | benign(0.169) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HACD1 | SNV | Missense_Mutation | c.614T>G | p.Phe205Cys | p.F205C | B0YJ81 | protein_coding | deleterious(0) | benign(0.1) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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