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Gene: H3F3C |
Gene summary for H3F3C |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | H3F3C | Gene ID | 440093 |
| Gene name | H3.5 histone | |
| Gene Alias | H3.5 | |
| Cytomap | 12p11.21 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q6NXT2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 440093 | H3F3C | P1_cSCC | Human | Skin | cSCC | 4.24e-08 | 2.79e-01 | 0.0292 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| H3F3C | SNV | Missense_Mutation | novel | c.139N>T | p.Ala47Ser | p.A47S | Q6NXT2 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.598) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| H3F3C | SNV | Missense_Mutation | c.315N>C | p.Glu105Asp | p.E105D | Q6NXT2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| H3F3C | SNV | Missense_Mutation | novel | c.239C>T | p.Thr80Ile | p.T80I | Q6NXT2 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.777) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| H3F3C | SNV | Missense_Mutation | rs558668798 | c.394N>A | p.Gly132Arg | p.G132R | Q6NXT2 | protein_coding | deleterious_low_confidence(0) | benign(0.419) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| H3F3C | SNV | Missense_Mutation | c.118N>T | p.Arg40Cys | p.R40C | Q6NXT2 | protein_coding | tolerated_low_confidence(0.05) | benign(0.031) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| H3F3C | SNV | Missense_Mutation | novel | c.136N>A | p.Val46Met | p.V46M | Q6NXT2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.04) | TCGA-A5-A7WK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
| H3F3C | SNV | Missense_Mutation | rs376467484 | c.148N>A | p.Glu50Lys | p.E50K | Q6NXT2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.893) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
| H3F3C | SNV | Missense_Mutation | novel | c.392N>T | p.Arg131Leu | p.R131L | Q6NXT2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.061) | TCGA-AP-A1DH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| H3F3C | SNV | Missense_Mutation | novel | c.367G>T | p.Asp123Tyr | p.D123Y | Q6NXT2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.963) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| H3F3C | SNV | Missense_Mutation | novel | c.68C>T | p.Thr23Met | p.T23M | Q6NXT2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.888) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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