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Gene: H3-3A |
Gene summary for H3-3A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | H3-3A | Gene ID | 3020 |
| Gene name | H3.3 histone A | |
| Gene Alias | H3-3B | |
| Cytomap | 1q42.12 | |
| Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | B2R4P9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3020 | H3-3A | CCI_1 | Human | Cervix | CC | 6.83e-53 | -1.86e+00 | 0.528 |
| 3020 | H3-3A | CCI_2 | Human | Cervix | CC | 8.12e-50 | -1.86e+00 | 0.5249 |
| 3020 | H3-3A | CCI_3 | Human | Cervix | CC | 6.78e-65 | -1.86e+00 | 0.516 |
| 3020 | H3-3A | CCII_1 | Human | Cervix | CC | 2.61e-82 | -1.86e+00 | 0.3249 |
| 3020 | H3-3A | Tumor | Human | Cervix | CC | 2.77e-138 | -1.86e+00 | 0.1241 |
| 3020 | H3-3A | sample1 | Human | Cervix | CC | 3.35e-72 | -1.86e+00 | 0.0959 |
| 3020 | H3-3A | sample3 | Human | Cervix | CC | 1.20e-141 | -1.86e+00 | 0.1387 |
| 3020 | H3-3A | H2 | Human | Cervix | HSIL_HPV | 3.41e-137 | -1.86e+00 | 0.0632 |
| 3020 | H3-3A | L1 | Human | Cervix | CC | 3.93e-88 | -1.86e+00 | 0.0802 |
| 3020 | H3-3A | T1 | Human | Cervix | CC | 4.05e-128 | -1.86e+00 | 0.0918 |
| 3020 | H3-3A | T2 | Human | Cervix | CC | 6.31e-48 | -1.86e+00 | 0.0709 |
| 3020 | H3-3A | T3 | Human | Cervix | CC | 1.65e-140 | -1.86e+00 | 0.1389 |
| 3020 | H3-3A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.41e-117 | 1.75e+00 | 0.0155 |
| 3020 | H3-3A | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.89e-94 | 2.37e+00 | -0.1808 |
| 3020 | H3-3A | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.84e-51 | 2.87e+00 | 0.0216 |
| 3020 | H3-3A | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.74e-89 | 2.83e+00 | -0.0811 |
| 3020 | H3-3A | HTA11_78_2000001011 | Human | Colorectum | AD | 2.91e-56 | 1.23e+00 | -0.1088 |
| 3020 | H3-3A | HTA11_347_2000001011 | Human | Colorectum | AD | 2.09e-127 | 2.35e+00 | -0.1954 |
| 3020 | H3-3A | HTA11_411_2000001011 | Human | Colorectum | SER | 2.57e-38 | 2.73e+00 | -0.2602 |
| 3020 | H3-3A | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.48e-41 | 2.40e+00 | -0.2196 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
| GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
| GO:00459277 | Cervix | CC | positive regulation of growth | 53/2311 | 259/18723 | 1.33e-04 | 1.64e-03 | 53 |
| GO:00015588 | Cervix | CC | regulation of cell growth | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
| GO:00303077 | Cervix | CC | positive regulation of cell growth | 36/2311 | 166/18723 | 4.84e-04 | 4.75e-03 | 36 |
| GO:00063381 | Cervix | CC | chromatin remodeling | 45/2311 | 255/18723 | 8.33e-03 | 4.30e-02 | 45 |
| GO:001604914 | Cervix | HSIL_HPV | cell growth | 32/737 | 482/18723 | 2.87e-03 | 2.70e-02 | 32 |
| GO:003030713 | Cervix | HSIL_HPV | positive regulation of cell growth | 14/737 | 166/18723 | 6.04e-03 | 4.75e-02 | 14 |
| GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
| GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
| GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
| GO:0030307 | Colorectum | AD | positive regulation of cell growth | 54/3918 | 166/18723 | 3.08e-04 | 3.69e-03 | 54 |
| GO:0045927 | Colorectum | AD | positive regulation of growth | 77/3918 | 259/18723 | 4.82e-04 | 5.27e-03 | 77 |
| GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
| GO:00015581 | Colorectum | SER | regulation of cell growth | 90/2897 | 414/18723 | 4.00e-04 | 6.02e-03 | 90 |
| GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
| GO:00160491 | Colorectum | SER | cell growth | 100/2897 | 482/18723 | 1.07e-03 | 1.24e-02 | 100 |
| GO:00303071 | Colorectum | SER | positive regulation of cell growth | 39/2897 | 166/18723 | 4.25e-03 | 3.45e-02 | 39 |
| GO:00459271 | Colorectum | SER | positive regulation of growth | 56/2897 | 259/18723 | 5.10e-03 | 3.91e-02 | 56 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
| hsa05131110 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
| hsa05322 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
| hsa0513125 | Cervix | HSIL_HPV | Shigellosis | 27/459 | 247/8465 | 3.78e-04 | 3.49e-03 | 2.82e-03 | 27 |
| hsa053221 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
| hsa0513135 | Cervix | HSIL_HPV | Shigellosis | 27/459 | 247/8465 | 3.78e-04 | 3.49e-03 | 2.82e-03 | 27 |
| hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
| hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
| hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
| hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 3020 | H3-3A | CLINICALLY ACTIONABLE, DRUGGABLE GENOME | AKT/ERK INHIBITOR ONC201 |
| Page: 1 |
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