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Gene: H2AZ2 |
Gene summary for H2AZ2 |
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Gene information | Species | Human | Gene symbol | H2AZ2 | Gene ID | 94239 |
Gene name | H2A.Z variant histone 2 | |
Gene Alias | H2A.Z-2 | |
Cytomap | 7p13 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q71UI9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
94239 | H2AZ2 | CA_HPV_1 | Human | Cervix | CC | 1.95e-08 | -9.74e-02 | 0.0264 |
94239 | H2AZ2 | N_HPV_2 | Human | Cervix | N_HPV | 3.50e-02 | 1.21e-01 | -0.0131 |
94239 | H2AZ2 | CCI_1 | Human | Cervix | CC | 6.43e-13 | -7.26e-01 | 0.528 |
94239 | H2AZ2 | CCI_2 | Human | Cervix | CC | 6.77e-12 | -7.26e-01 | 0.5249 |
94239 | H2AZ2 | CCI_3 | Human | Cervix | CC | 5.04e-17 | -7.26e-01 | 0.516 |
94239 | H2AZ2 | CCII_1 | Human | Cervix | CC | 2.80e-23 | -7.26e-01 | 0.3249 |
94239 | H2AZ2 | Tumor | Human | Cervix | CC | 3.68e-47 | -7.26e-01 | 0.1241 |
94239 | H2AZ2 | sample1 | Human | Cervix | CC | 1.32e-19 | -7.26e-01 | 0.0959 |
94239 | H2AZ2 | sample3 | Human | Cervix | CC | 1.05e-46 | -7.26e-01 | 0.1387 |
94239 | H2AZ2 | H2 | Human | Cervix | HSIL_HPV | 2.96e-46 | -7.26e-01 | 0.0632 |
94239 | H2AZ2 | L1 | Human | Cervix | CC | 1.93e-25 | -7.26e-01 | 0.0802 |
94239 | H2AZ2 | T1 | Human | Cervix | CC | 4.17e-41 | -7.26e-01 | 0.0918 |
94239 | H2AZ2 | T2 | Human | Cervix | CC | 2.84e-11 | -7.26e-01 | 0.0709 |
94239 | H2AZ2 | T3 | Human | Cervix | CC | 1.56e-48 | -7.26e-01 | 0.1389 |
94239 | H2AZ2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.20e-21 | 3.90e-01 | 0.0155 |
94239 | H2AZ2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.28e-25 | 5.54e-01 | -0.1808 |
94239 | H2AZ2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.20e-12 | 5.38e-01 | 0.0216 |
94239 | H2AZ2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.48e-27 | 8.54e-01 | -0.0811 |
94239 | H2AZ2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.29e-24 | 5.91e-01 | -0.1088 |
94239 | H2AZ2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.44e-49 | 9.72e-01 | -0.1954 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05322 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
hsa053221 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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