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Gene: H2AC6 |
Gene summary for H2AC6 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | H2AC6 | Gene ID | 8334 |
| Gene name | H2A clustered histone 6 | |
| Gene Alias | H2A/l | |
| Cytomap | 6p22.2 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024R017 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8334 | H2AC6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.51e-03 | 1.13e-01 | 0.0155 |
| 8334 | H2AC6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.89e-04 | 1.98e-01 | -0.1808 |
| 8334 | H2AC6 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.85e-14 | 3.92e-01 | -0.0811 |
| 8334 | H2AC6 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.58e-08 | 2.56e-01 | -0.1088 |
| 8334 | H2AC6 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.04e-25 | 5.61e-01 | -0.1954 |
| 8334 | H2AC6 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 2.55e-01 | -0.2602 |
| 8334 | H2AC6 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.90e-02 | 2.44e-01 | -0.2196 |
| 8334 | H2AC6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.34e-03 | 1.57e-01 | -0.1207 |
| 8334 | H2AC6 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.12e-08 | 5.10e-01 | -0.1526 |
| 8334 | H2AC6 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.58e-13 | 2.94e-01 | -0.1464 |
| 8334 | H2AC6 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.52e-13 | 3.37e-01 | -0.1001 |
| 8334 | H2AC6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.99e-16 | 3.99e-01 | -0.059 |
| 8334 | H2AC6 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.72e-05 | 3.33e-01 | -0.1706 |
| 8334 | H2AC6 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.21e-08 | 3.63e-01 | -0.2061 |
| 8334 | H2AC6 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.84e-10 | 7.16e-01 | -0.1462 |
| 8334 | H2AC6 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.56e-06 | 3.18e-01 | -0.0842 |
| 8334 | H2AC6 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.96e-03 | 2.52e-01 | -0.0179 |
| 8334 | H2AC6 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.43e-14 | 3.60e-01 | 0.096 |
| 8334 | H2AC6 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.14e-04 | 2.26e-01 | 0.0528 |
| 8334 | H2AC6 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.58e-06 | 3.34e-01 | 0.0131 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
| hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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