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Gene: H1-10 |
Gene summary for H1-10 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | H1-10 | Gene ID | 8971 |
| Gene name | H1.10 linker histone | |
| Gene Alias | H1.10 | |
| Cytomap | 3q21.3 | |
| Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q92522 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8971 | H1-10 | CA_HPV_1 | Human | Cervix | CC | 6.02e-08 | 4.64e-02 | 0.0264 |
| 8971 | H1-10 | CA_HPV_3 | Human | Cervix | CC | 5.54e-04 | 2.10e-01 | 0.0414 |
| 8971 | H1-10 | CCI_1 | Human | Cervix | CC | 1.51e-08 | -5.15e-01 | 0.528 |
| 8971 | H1-10 | CCI_2 | Human | Cervix | CC | 8.65e-08 | -5.15e-01 | 0.5249 |
| 8971 | H1-10 | CCI_3 | Human | Cervix | CC | 1.36e-11 | -5.15e-01 | 0.516 |
| 8971 | H1-10 | CCII_1 | Human | Cervix | CC | 2.98e-16 | -5.15e-01 | 0.3249 |
| 8971 | H1-10 | Tumor | Human | Cervix | CC | 2.00e-29 | -5.15e-01 | 0.1241 |
| 8971 | H1-10 | sample1 | Human | Cervix | CC | 1.63e-13 | -5.15e-01 | 0.0959 |
| 8971 | H1-10 | sample3 | Human | Cervix | CC | 8.06e-30 | -5.15e-01 | 0.1387 |
| 8971 | H1-10 | H2 | Human | Cervix | HSIL_HPV | 3.29e-32 | -5.15e-01 | 0.0632 |
| 8971 | H1-10 | L1 | Human | Cervix | CC | 7.21e-18 | -5.15e-01 | 0.0802 |
| 8971 | H1-10 | T1 | Human | Cervix | CC | 1.19e-29 | -5.15e-01 | 0.0918 |
| 8971 | H1-10 | T2 | Human | Cervix | CC | 2.50e-07 | -5.15e-01 | 0.0709 |
| 8971 | H1-10 | T3 | Human | Cervix | CC | 3.25e-30 | -5.15e-01 | 0.1389 |
| 8971 | H1-10 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.81e-06 | 1.54e-01 | 0.0155 |
| 8971 | H1-10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.32e-08 | 2.75e-01 | -0.1808 |
| 8971 | H1-10 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.03e-06 | 3.63e-01 | 0.0216 |
| 8971 | H1-10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.27e-05 | 2.32e-01 | -0.0811 |
| 8971 | H1-10 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.20e-06 | 1.76e-01 | -0.1088 |
| 8971 | H1-10 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.65e-09 | 2.27e-01 | -0.1954 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
| GO:00510528 | Cervix | CC | regulation of DNA metabolic process | 65/2311 | 359/18723 | 9.25e-04 | 7.84e-03 | 65 |
| GO:00063381 | Cervix | CC | chromatin remodeling | 45/2311 | 255/18723 | 8.33e-03 | 4.30e-02 | 45 |
| GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
| GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
| GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
| GO:00510521 | Colorectum | SER | regulation of DNA metabolic process | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
| GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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