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Gene: H1-0 |
Gene summary for H1-0 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | H1-0 | Gene ID | 3005 |
| Gene name | H1.0 linker histone | |
| Gene Alias | H1.0 | |
| Cytomap | 22q13.1 | |
| Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | P07305 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3005 | H1-0 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.59e-25 | 4.40e-01 | 0.0155 |
| 3005 | H1-0 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.28e-26 | 5.75e-01 | -0.1808 |
| 3005 | H1-0 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-03 | 2.52e-01 | 0.0216 |
| 3005 | H1-0 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.05e-20 | 7.16e-01 | -0.0811 |
| 3005 | H1-0 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.29e-24 | 6.30e-01 | -0.1088 |
| 3005 | H1-0 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.50e-55 | 9.27e-01 | -0.1954 |
| 3005 | H1-0 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.51e-16 | 1.15e+00 | -0.2602 |
| 3005 | H1-0 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.88e-11 | 7.74e-01 | -0.2196 |
| 3005 | H1-0 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.71e-10 | 4.18e-01 | -0.1207 |
| 3005 | H1-0 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.54e-17 | 4.76e-01 | -0.1526 |
| 3005 | H1-0 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.38e-30 | 5.83e-01 | -0.1464 |
| 3005 | H1-0 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.12e-29 | 5.37e-01 | -0.1001 |
| 3005 | H1-0 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.67e-29 | 6.75e-01 | -0.059 |
| 3005 | H1-0 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.03e-15 | 5.66e-01 | -0.1706 |
| 3005 | H1-0 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.67e-10 | 4.59e-01 | -0.2061 |
| 3005 | H1-0 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.49e-08 | 5.38e-01 | -0.1462 |
| 3005 | H1-0 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.42e-10 | 4.02e-01 | -0.0842 |
| 3005 | H1-0 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.00e-20 | 6.81e-01 | -0.0179 |
| 3005 | H1-0 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.40e-16 | 3.50e-01 | 0.096 |
| 3005 | H1-0 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-03 | 3.08e-01 | 0.0446 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
| GO:0051099 | Colorectum | AD | positive regulation of binding | 66/3918 | 173/18723 | 1.47e-07 | 6.64e-06 | 66 |
| GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
| GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
| GO:0051101 | Colorectum | AD | regulation of DNA binding | 42/3918 | 118/18723 | 1.62e-04 | 2.23e-03 | 42 |
| GO:0043388 | Colorectum | AD | positive regulation of DNA binding | 23/3918 | 56/18723 | 4.91e-04 | 5.32e-03 | 23 |
| GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
| GO:00510981 | Colorectum | SER | regulation of binding | 97/2897 | 363/18723 | 1.98e-08 | 1.43e-06 | 97 |
| GO:00510521 | Colorectum | SER | regulation of DNA metabolic process | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
| GO:00510991 | Colorectum | SER | positive regulation of binding | 46/2897 | 173/18723 | 1.12e-04 | 2.34e-03 | 46 |
| GO:00511011 | Colorectum | SER | regulation of DNA binding | 33/2897 | 118/18723 | 3.70e-04 | 5.71e-03 | 33 |
| GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
| GO:00433881 | Colorectum | SER | positive regulation of DNA binding | 19/2897 | 56/18723 | 4.92e-04 | 7.02e-03 | 19 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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