![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GZMM |
Gene summary for GZMM |
![]() |
Gene information | Species | Human | Gene symbol | GZMM | Gene ID | 3004 |
Gene name | granzyme M | |
Gene Alias | LMET1 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001906 | UniProtAcc | P51124 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3004 | GZMM | C38 | Human | Oral cavity | OSCC | 7.18e-05 | 5.19e-01 | 0.172 |
3004 | GZMM | C06 | Human | Oral cavity | OSCC | 1.18e-03 | 5.25e-01 | 0.2699 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GZMM | SNV | Missense_Mutation | novel | c.268N>C | p.Thr90Pro | p.T90P | P51124 | protein_coding | tolerated(0.21) | benign(0.388) | TCGA-A8-A09V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
GZMM | SNV | Missense_Mutation | c.694N>T | p.Asp232Tyr | p.D232Y | P51124 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GZMM | SNV | Missense_Mutation | novel | c.733N>G | p.Tyr245Asp | p.Y245D | P51124 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
GZMM | SNV | Missense_Mutation | novel | c.691N>C | p.Thr231Pro | p.T231P | P51124 | protein_coding | tolerated(0.06) | benign(0.313) | TCGA-C5-A2M1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GZMM | SNV | Missense_Mutation | c.753G>T | p.Lys251Asn | p.K251N | P51124 | protein_coding | tolerated(0.06) | benign(0.009) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GZMM | SNV | Missense_Mutation | c.502N>A | p.Leu168Ile | p.L168I | P51124 | protein_coding | tolerated(0.09) | benign(0.202) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GZMM | deletion | Frame_Shift_Del | c.39delN | p.Ala15ProfsTer4 | p.A15Pfs*4 | P51124 | protein_coding | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |||
GZMM | SNV | Missense_Mutation | novel | c.8C>A | p.Ala3Asp | p.A3D | P51124 | protein_coding | tolerated_low_confidence(0.09) | benign(0.07) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GZMM | SNV | Missense_Mutation | rs780505573 | c.728C>T | p.Ala243Val | p.A243V | P51124 | protein_coding | tolerated(0.49) | possibly_damaging(0.533) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
GZMM | SNV | Missense_Mutation | novel | c.258N>A | p.Ser86Arg | p.S86R | P51124 | protein_coding | tolerated(0.26) | benign(0.039) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |