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Gene: GTPBP2 |
Gene summary for GTPBP2 |
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Gene information | Species | Human | Gene symbol | GTPBP2 | Gene ID | 54676 |
Gene name | GTP binding protein 2 | |
Gene Alias | JABELS | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A8K2K2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54676 | GTPBP2 | LZE7T | Human | Esophagus | ESCC | 3.74e-02 | 1.18e-01 | 0.0667 |
54676 | GTPBP2 | P1T-E | Human | Esophagus | ESCC | 1.11e-03 | 1.82e-01 | 0.0875 |
54676 | GTPBP2 | P4T-E | Human | Esophagus | ESCC | 7.98e-05 | 6.61e-02 | 0.1323 |
54676 | GTPBP2 | P8T-E | Human | Esophagus | ESCC | 3.42e-05 | 8.70e-02 | 0.0889 |
54676 | GTPBP2 | P9T-E | Human | Esophagus | ESCC | 2.85e-09 | 1.41e-01 | 0.1131 |
54676 | GTPBP2 | P10T-E | Human | Esophagus | ESCC | 2.03e-03 | 4.63e-02 | 0.116 |
54676 | GTPBP2 | P11T-E | Human | Esophagus | ESCC | 1.87e-08 | 2.59e-01 | 0.1426 |
54676 | GTPBP2 | P15T-E | Human | Esophagus | ESCC | 2.69e-04 | 5.36e-02 | 0.1149 |
54676 | GTPBP2 | P17T-E | Human | Esophagus | ESCC | 1.32e-03 | 2.93e-01 | 0.1278 |
54676 | GTPBP2 | P19T-E | Human | Esophagus | ESCC | 2.05e-03 | 2.61e-01 | 0.1662 |
54676 | GTPBP2 | P21T-E | Human | Esophagus | ESCC | 1.80e-02 | 6.66e-02 | 0.1617 |
54676 | GTPBP2 | P23T-E | Human | Esophagus | ESCC | 1.25e-06 | 1.20e-01 | 0.108 |
54676 | GTPBP2 | P24T-E | Human | Esophagus | ESCC | 9.59e-05 | 1.08e-01 | 0.1287 |
54676 | GTPBP2 | P27T-E | Human | Esophagus | ESCC | 7.40e-03 | 5.82e-02 | 0.1055 |
54676 | GTPBP2 | P28T-E | Human | Esophagus | ESCC | 1.27e-04 | 1.15e-01 | 0.1149 |
54676 | GTPBP2 | P30T-E | Human | Esophagus | ESCC | 1.11e-03 | 1.40e-01 | 0.137 |
54676 | GTPBP2 | P31T-E | Human | Esophagus | ESCC | 1.19e-09 | 1.47e-01 | 0.1251 |
54676 | GTPBP2 | P37T-E | Human | Esophagus | ESCC | 1.03e-06 | 1.23e-01 | 0.1371 |
54676 | GTPBP2 | P39T-E | Human | Esophagus | ESCC | 3.28e-04 | 8.45e-02 | 0.0894 |
54676 | GTPBP2 | P42T-E | Human | Esophagus | ESCC | 2.79e-04 | 1.39e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:000641412 | Liver | HCC | translational elongation | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:000641416 | Oral cavity | OSCC | translational elongation | 37/7305 | 55/18723 | 2.03e-05 | 1.94e-04 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTPBP2 | SNV | Missense_Mutation | c.555N>C | p.Lys185Asn | p.K185N | Q9BX10 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B6-A0WV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP2 | SNV | Missense_Mutation | novel | c.401N>G | p.Val134Gly | p.V134G | Q9BX10 | protein_coding | deleterious(0) | possibly_damaging(0.497) | TCGA-D8-A1XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
GTPBP2 | insertion | Frame_Shift_Ins | novel | c.1478_1479insAAAAGCAGAAAATATTTTTGAAGAAAAAAATTTCCTG | p.Met493IlefsTer27 | p.M493Ifs*27 | Q9BX10 | protein_coding | TCGA-A2-A0ER-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
GTPBP2 | insertion | Frame_Shift_Ins | novel | c.1413_1414insTTCTGGAGAGGTGCCAAACTTGGTGTGGCCAGGAAAGG | p.Gly472PhefsTer34 | p.G472Ffs*34 | Q9BX10 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
GTPBP2 | SNV | Missense_Mutation | rs770981387 | c.301G>A | p.Val101Ile | p.V101I | Q9BX10 | protein_coding | tolerated(1) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GTPBP2 | SNV | Missense_Mutation | c.1292C>G | p.Ser431Cys | p.S431C | Q9BX10 | protein_coding | tolerated(0.14) | benign(0.338) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
GTPBP2 | SNV | Missense_Mutation | rs769723702 | c.1382G>A | p.Arg461His | p.R461H | Q9BX10 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
GTPBP2 | SNV | Missense_Mutation | rs754859335 | c.1243G>A | p.Glu415Lys | p.E415K | Q9BX10 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-AA-3851-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GTPBP2 | SNV | Missense_Mutation | novel | c.807N>G | p.His269Gln | p.H269Q | Q9BX10 | protein_coding | deleterious(0) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTPBP2 | SNV | Missense_Mutation | rs779230466 | c.1585N>A | p.Val529Met | p.V529M | Q9BX10 | protein_coding | deleterious(0.01) | possibly_damaging(0.824) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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