Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: GTF2B

Gene summary for GTF2B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

GTF2B

Gene ID

2959

Gene namegeneral transcription factor IIB
Gene AliasTF2B
Cytomap1p22.2
Gene Typeprotein-coding
GO ID

GO:0001173

UniProtAcc

Q00403


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
2959GTF2BLZE2THumanEsophagusESCC1.01e-021.28e-010.082
2959GTF2BLZE4THumanEsophagusESCC1.25e-123.36e-010.0811
2959GTF2BLZE5THumanEsophagusESCC8.09e-052.28e-010.0514
2959GTF2BLZE7THumanEsophagusESCC1.21e-115.93e-010.0667
2959GTF2BLZE8THumanEsophagusESCC3.01e-127.69e-010.067
2959GTF2BLZE20THumanEsophagusESCC4.67e-073.47e-010.0662
2959GTF2BLZE22D1HumanEsophagusHGIN9.70e-032.23e-020.0595
2959GTF2BLZE22THumanEsophagusESCC4.57e-02-1.24e-010.068
2959GTF2BLZE24THumanEsophagusESCC5.13e-205.77e-010.0596
2959GTF2BLZE21THumanEsophagusESCC4.55e-034.56e-010.0655
2959GTF2BLZE6THumanEsophagusESCC3.04e-063.98e-010.0845
2959GTF2BP1T-EHumanEsophagusESCC4.02e-025.76e-010.0875
2959GTF2BP2T-EHumanEsophagusESCC5.84e-326.49e-010.1177
2959GTF2BP4T-EHumanEsophagusESCC4.39e-255.08e-010.1323
2959GTF2BP5T-EHumanEsophagusESCC1.59e-164.87e-010.1327
2959GTF2BP8T-EHumanEsophagusESCC1.09e-264.16e-010.0889
2959GTF2BP9T-EHumanEsophagusESCC2.27e-211.87e-010.1131
2959GTF2BP10T-EHumanEsophagusESCC3.02e-325.97e-010.116
2959GTF2BP11T-EHumanEsophagusESCC1.42e-137.30e-010.1426
2959GTF2BP12T-EHumanEsophagusESCC1.50e-752.43e+000.1122
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001603227EsophagusHGINviral process118/2587415/187233.01e-156.22e-13118
GO:00182057EsophagusHGINpeptidyl-lysine modification88/2587376/187232.99e-071.39e-0588
GO:005109825EsophagusHGINregulation of binding78/2587363/187233.73e-059.30e-0478
GO:001908016EsophagusHGINviral gene expression28/258794/187234.52e-051.09e-0328
GO:005109925EsophagusHGINpositive regulation of binding42/2587173/187231.51e-042.97e-0342
GO:00165708EsophagusHGINhistone modification92/2587463/187231.70e-043.30e-0392
GO:00064735EsophagusHGINprotein acetylation45/2587201/187236.17e-048.58e-0345
GO:00183945EsophagusHGINpeptidyl-lysine acetylation39/2587169/187237.46e-049.90e-0339
GO:00435435EsophagusHGINprotein acylation51/2587243/187231.33e-031.57e-0251
GO:00064755EsophagusHGINinternal protein amino acid acetylation36/2587160/187231.87e-032.01e-0236
GO:00190834EsophagusHGINviral transcription15/258750/187232.35e-032.39e-0215
GO:005110125EsophagusHGINregulation of DNA binding28/2587118/187232.54e-032.51e-0228
GO:00183935EsophagusHGINinternal peptidyl-lysine acetylation35/2587158/187232.82e-032.75e-0235
GO:00063523EsophagusHGINDNA-templated transcription, initiation30/2587130/187232.86e-032.79e-0230
GO:004338818EsophagusHGINpositive regulation of DNA binding16/258756/187232.96e-032.86e-0216
GO:0016032111EsophagusESCCviral process301/8552415/187233.34e-291.32e-26301
GO:001657015EsophagusESCChistone modification323/8552463/187232.61e-267.88e-24323
GO:001820514EsophagusESCCpeptidyl-lysine modification259/8552376/187233.90e-205.26e-18259
GO:0051098111EsophagusESCCregulation of binding251/8552363/187236.73e-208.46e-18251
GO:001908017EsophagusESCCviral gene expression80/855294/187232.04e-151.28e-1380
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0501727EsophagusHGINSpinocerebellar ataxia43/1383143/84652.68e-053.64e-042.89e-0443
hsa052039EsophagusHGINViral carcinogenesis53/1383204/84652.58e-042.71e-032.15e-0353
hsa05017112EsophagusHGINSpinocerebellar ataxia43/1383143/84652.68e-053.64e-042.89e-0443
hsa0520315EsophagusHGINViral carcinogenesis53/1383204/84652.58e-042.71e-032.15e-0353
hsa0520325EsophagusESCCViral carcinogenesis137/4205204/84652.47e-071.88e-069.62e-07137
hsa0501728EsophagusESCCSpinocerebellar ataxia94/4205143/84656.77e-052.90e-041.48e-0494
hsa0520335EsophagusESCCViral carcinogenesis137/4205204/84652.47e-071.88e-069.62e-07137
hsa0501736EsophagusESCCSpinocerebellar ataxia94/4205143/84656.77e-052.90e-041.48e-0494
hsa0501710LiverCirrhoticSpinocerebellar ataxia66/2530143/84652.58e-052.15e-041.32e-0466
hsa05203LiverCirrhoticViral carcinogenesis76/2530204/84651.34e-024.20e-022.59e-0276
hsa0501711LiverCirrhoticSpinocerebellar ataxia66/2530143/84652.58e-052.15e-041.32e-0466
hsa052031LiverCirrhoticViral carcinogenesis76/2530204/84651.34e-024.20e-022.59e-0276
hsa0501721LiverHCCSpinocerebellar ataxia92/4020143/84653.20e-051.88e-041.04e-0492
hsa052032LiverHCCViral carcinogenesis117/4020204/84652.68e-038.98e-035.00e-03117
hsa0501731LiverHCCSpinocerebellar ataxia92/4020143/84653.20e-051.88e-041.04e-0492
hsa052033LiverHCCViral carcinogenesis117/4020204/84652.68e-038.98e-035.00e-03117
hsa052038Oral cavityOSCCViral carcinogenesis124/3704204/84655.57e-073.28e-061.67e-06124
hsa0501725Oral cavityOSCCSpinocerebellar ataxia86/3704143/84655.21e-052.08e-041.06e-0486
hsa03022Oral cavityOSCCBasal transcription factors28/370445/84659.53e-032.11e-021.08e-0228
hsa0520314Oral cavityOSCCViral carcinogenesis124/3704204/84655.57e-073.28e-061.67e-06124
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
GTF2BCD8TRMCervixN_HPVANKRD54,DBP,BPGM, etc.2.89e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
GTF2BTH17ColorectumHealthyGPR155,CCDC66,LINC00894, etc.3.72e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
GTF2BSTMEsophagusLGINLMO4,SPTSSA,RPL5, etc.7.05e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
GTF2BMAITOral cavityNEOLPCXCR4,KIAA0226L,DNAJA1, etc.2.12e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
GTF2BCD4TNPancreasPDACCXCR4,NFE2L3,DDX5, etc.1.98e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
GTF2BCD8TEXPancreasPDACCXCR4,NFE2L3,DDX5, etc.9.99e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
GTF2BPARIStomachWIMTIAM1,TTR,NR2C1, etc.1.54e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
GTF2BSNVMissense_Mutationrs144944840c.395G>Ap.Arg132Glnp.R132QQ00403protein_codingtolerated(0.35)benign(0.015)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
GTF2BinsertionFrame_Shift_Insnovelc.354_355insCTCCTGATCATTTTGAATACTCTp.Lys119LeufsTer24p.K119Lfs*24Q00403protein_codingTCGA-AN-A0FS-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
GTF2BSNVMissense_Mutationc.578G>Ap.Arg193Glnp.R193QQ00403protein_codingtolerated(0.07)probably_damaging(0.967)TCGA-AA-3510-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
GTF2BSNVMissense_Mutationrs760691499c.884N>Ap.Arg295Glnp.R295QQ00403protein_codingtolerated(0.05)benign(0.039)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
GTF2BSNVMissense_Mutationrs144944840c.395G>Ap.Arg132Glnp.R132QQ00403protein_codingtolerated(0.35)benign(0.015)TCGA-AZ-4315-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
GTF2BSNVMissense_Mutationc.146N>Tp.Gly49Valp.G49VQ00403protein_codingdeleterious(0.02)probably_damaging(0.978)TCGA-D5-6928-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
GTF2BSNVMissense_Mutationnovelc.310C>Tp.Arg104Trpp.R104WQ00403protein_codingdeleterious(0)probably_damaging(0.963)TCGA-F5-6814-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
GTF2BSNVMissense_Mutationnovelc.158N>Ap.Arg53Glnp.R53QQ00403protein_codingdeleterious(0.02)probably_damaging(0.997)TCGA-A5-A0G1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
GTF2BSNVMissense_Mutationnovelc.614N>Ap.Ser205Asnp.S205NQ00403protein_codingtolerated(0.39)benign(0)TCGA-A5-A0GI-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
GTF2BSNVMissense_Mutationc.862N>Cp.Ser288Prop.S288PQ00403protein_codingdeleterious(0.01)possibly_damaging(0.884)TCGA-A5-A0VP-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
2959GTF2BTRANSCRIPTION FACTORVITAMIN D9013769,7876247
2959GTF2BTRANSCRIPTION FACTORPC48617240
2959GTF2BTRANSCRIPTION FACTORSTEROID HORMONE1517211
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