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Gene: GTDC1 |
Gene summary for GTDC1 |
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Gene information | Species | Human | Gene symbol | GTDC1 | Gene ID | 79712 |
Gene name | glycosyltransferase like domain containing 1 | |
Gene Alias | Hmat-Xa | |
Cytomap | 2q22.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q4AE62 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79712 | GTDC1 | CCI_1 | Human | Cervix | CC | 9.22e-14 | 9.30e-01 | 0.528 |
79712 | GTDC1 | CCI_3 | Human | Cervix | CC | 1.02e-10 | 6.51e-01 | 0.516 |
79712 | GTDC1 | LZE4T | Human | Esophagus | ESCC | 2.90e-08 | 2.22e-01 | 0.0811 |
79712 | GTDC1 | LZE7T | Human | Esophagus | ESCC | 2.99e-05 | 2.35e-01 | 0.0667 |
79712 | GTDC1 | LZE24T | Human | Esophagus | ESCC | 1.88e-02 | 5.05e-02 | 0.0596 |
79712 | GTDC1 | P2T-E | Human | Esophagus | ESCC | 1.09e-02 | 1.68e-02 | 0.1177 |
79712 | GTDC1 | P4T-E | Human | Esophagus | ESCC | 3.95e-06 | 1.80e-01 | 0.1323 |
79712 | GTDC1 | P5T-E | Human | Esophagus | ESCC | 1.14e-18 | 2.51e-01 | 0.1327 |
79712 | GTDC1 | P8T-E | Human | Esophagus | ESCC | 7.85e-12 | 9.34e-02 | 0.0889 |
79712 | GTDC1 | P9T-E | Human | Esophagus | ESCC | 5.18e-04 | 6.63e-02 | 0.1131 |
79712 | GTDC1 | P10T-E | Human | Esophagus | ESCC | 6.56e-09 | 1.50e-01 | 0.116 |
79712 | GTDC1 | P11T-E | Human | Esophagus | ESCC | 1.17e-09 | 2.87e-01 | 0.1426 |
79712 | GTDC1 | P12T-E | Human | Esophagus | ESCC | 8.61e-13 | 2.98e-01 | 0.1122 |
79712 | GTDC1 | P15T-E | Human | Esophagus | ESCC | 1.84e-12 | 2.82e-01 | 0.1149 |
79712 | GTDC1 | P16T-E | Human | Esophagus | ESCC | 5.23e-07 | 2.87e-02 | 0.1153 |
79712 | GTDC1 | P20T-E | Human | Esophagus | ESCC | 3.99e-02 | 5.94e-02 | 0.1124 |
79712 | GTDC1 | P21T-E | Human | Esophagus | ESCC | 6.71e-09 | 8.02e-02 | 0.1617 |
79712 | GTDC1 | P22T-E | Human | Esophagus | ESCC | 4.25e-04 | 1.13e-01 | 0.1236 |
79712 | GTDC1 | P23T-E | Human | Esophagus | ESCC | 3.58e-07 | 2.14e-01 | 0.108 |
79712 | GTDC1 | P24T-E | Human | Esophagus | ESCC | 1.26e-03 | 9.43e-02 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTDC1 | SNV | Missense_Mutation | novel | c.257N>A | p.Ile86Asn | p.I86N | Q4AE62 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-C8-A12K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GTDC1 | SNV | Missense_Mutation | c.997N>C | p.Glu333Gln | p.E333Q | Q4AE62 | protein_coding | tolerated(0.09) | possibly_damaging(0.653) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
GTDC1 | SNV | Missense_Mutation | rs150712882 | c.1141N>A | p.Val381Met | p.V381M | Q4AE62 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A1NF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD |
GTDC1 | insertion | Nonsense_Mutation | novel | c.527_528insTACCTAAGCGAGCCATGTCAGCTCTCTG | p.Met176IlefsTer3 | p.M176Ifs*3 | Q4AE62 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GTDC1 | SNV | Missense_Mutation | novel | c.624N>C | p.Gln208His | p.Q208H | Q4AE62 | protein_coding | tolerated_low_confidence(0.39) | benign(0.088) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
GTDC1 | SNV | Missense_Mutation | novel | c.624N>C | p.Gln208His | p.Q208H | Q4AE62 | protein_coding | tolerated_low_confidence(0.39) | benign(0.088) | TCGA-EK-A2RM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GTDC1 | SNV | Missense_Mutation | c.27C>G | p.Phe9Leu | p.F9L | Q4AE62 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EX-A1H6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GTDC1 | SNV | Missense_Mutation | novel | c.101N>T | p.Pro34Leu | p.P34L | Q4AE62 | protein_coding | deleterious(0) | possibly_damaging(0.566) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GTDC1 | SNV | Missense_Mutation | rs142181617 | c.214G>A | p.Glu72Lys | p.E72K | Q4AE62 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GTDC1 | SNV | Missense_Mutation | c.636G>T | p.Glu212Asp | p.E212D | Q4AE62 | protein_coding | tolerated_low_confidence(0.26) | benign(0.021) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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