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Gene: GSTM1 |
Gene summary for GSTM1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GSTM1 | Gene ID | 2944 |
| Gene name | glutathione S-transferase mu 1 | |
| Gene Alias | GST1 | |
| Cytomap | 1p13.3 | |
| Gene Type | protein-coding | GO ID | GO:0001676 | UniProtAcc | P09488 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2944 | GSTM1 | LZE3D | Human | Esophagus | HGIN | 3.66e-03 | 4.85e-01 | 0.0668 |
| 2944 | GSTM1 | LZE8T | Human | Esophagus | ESCC | 2.13e-11 | 3.27e-01 | 0.067 |
| 2944 | GSTM1 | LZE20T | Human | Esophagus | ESCC | 3.35e-21 | 1.27e+00 | 0.0662 |
| 2944 | GSTM1 | LZE21D1 | Human | Esophagus | HGIN | 1.07e-09 | 2.27e+00 | 0.0632 |
| 2944 | GSTM1 | LZE21T | Human | Esophagus | ESCC | 5.58e-24 | 2.48e+00 | 0.0655 |
| 2944 | GSTM1 | LZE6T | Human | Esophagus | ESCC | 2.96e-03 | 1.56e-01 | 0.0845 |
| 2944 | GSTM1 | P1T-E | Human | Esophagus | ESCC | 5.75e-15 | 1.15e+00 | 0.0875 |
| 2944 | GSTM1 | P2T-E | Human | Esophagus | ESCC | 5.53e-63 | 1.07e+00 | 0.1177 |
| 2944 | GSTM1 | P8T-E | Human | Esophagus | ESCC | 4.19e-25 | 4.64e-01 | 0.0889 |
| 2944 | GSTM1 | P11T-E | Human | Esophagus | ESCC | 4.42e-37 | 2.09e+00 | 0.1426 |
| 2944 | GSTM1 | P15T-E | Human | Esophagus | ESCC | 2.14e-102 | 3.41e+00 | 0.1149 |
| 2944 | GSTM1 | P16T-E | Human | Esophagus | ESCC | 1.96e-56 | 9.34e-01 | 0.1153 |
| 2944 | GSTM1 | P22T-E | Human | Esophagus | ESCC | 2.93e-130 | 2.57e+00 | 0.1236 |
| 2944 | GSTM1 | P23T-E | Human | Esophagus | ESCC | 1.52e-59 | 2.01e+00 | 0.108 |
| 2944 | GSTM1 | P24T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.89e-01 | 0.1287 |
| 2944 | GSTM1 | P31T-E | Human | Esophagus | ESCC | 6.26e-61 | 1.37e+00 | 0.1251 |
| 2944 | GSTM1 | P32T-E | Human | Esophagus | ESCC | 1.71e-81 | 2.38e+00 | 0.1666 |
| 2944 | GSTM1 | P37T-E | Human | Esophagus | ESCC | 7.19e-39 | 9.51e-01 | 0.1371 |
| 2944 | GSTM1 | P39T-E | Human | Esophagus | ESCC | 4.93e-91 | 3.76e+00 | 0.0894 |
| 2944 | GSTM1 | P42T-E | Human | Esophagus | ESCC | 5.16e-55 | 2.50e+00 | 0.1175 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00066929 | Esophagus | HGIN | prostanoid metabolic process | 17/2587 | 49/18723 | 1.84e-04 | 3.48e-03 | 17 |
| GO:00066939 | Esophagus | HGIN | prostaglandin metabolic process | 17/2587 | 49/18723 | 1.84e-04 | 3.48e-03 | 17 |
| GO:00067497 | Esophagus | HGIN | glutathione metabolic process | 20/2587 | 64/18723 | 2.63e-04 | 4.58e-03 | 20 |
| GO:199074820 | Esophagus | HGIN | cellular detoxification | 30/2587 | 116/18723 | 4.05e-04 | 6.15e-03 | 30 |
| GO:009723720 | Esophagus | HGIN | cellular response to toxic substance | 30/2587 | 124/18723 | 1.32e-03 | 1.57e-02 | 30 |
| GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
| GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
| GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
| GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
| GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
| GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
| GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
| GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
| GO:000674912 | Esophagus | ESCC | glutathione metabolic process | 42/8552 | 64/18723 | 1.01e-03 | 5.12e-03 | 42 |
| GO:1990748110 | Esophagus | ESCC | cellular detoxification | 70/8552 | 116/18723 | 1.02e-03 | 5.17e-03 | 70 |
| GO:000669211 | Esophagus | ESCC | prostanoid metabolic process | 33/8552 | 49/18723 | 1.80e-03 | 8.26e-03 | 33 |
| GO:000669311 | Esophagus | ESCC | prostaglandin metabolic process | 33/8552 | 49/18723 | 1.80e-03 | 8.26e-03 | 33 |
| GO:0097237110 | Esophagus | ESCC | cellular response to toxic substance | 72/8552 | 124/18723 | 3.65e-03 | 1.49e-02 | 72 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0520839 | Esophagus | HGIN | Chemical carcinogenesis - reactive oxygen species | 92/1383 | 223/8465 | 2.41e-19 | 9.83e-18 | 7.80e-18 | 92 |
| hsa0541839 | Esophagus | HGIN | Fluid shear stress and atherosclerosis | 42/1383 | 139/8465 | 2.92e-05 | 3.81e-04 | 3.02e-04 | 42 |
| hsa05208115 | Esophagus | HGIN | Chemical carcinogenesis - reactive oxygen species | 92/1383 | 223/8465 | 2.41e-19 | 9.83e-18 | 7.80e-18 | 92 |
| hsa05418115 | Esophagus | HGIN | Fluid shear stress and atherosclerosis | 42/1383 | 139/8465 | 2.92e-05 | 3.81e-04 | 3.02e-04 | 42 |
| hsa05208211 | Esophagus | ESCC | Chemical carcinogenesis - reactive oxygen species | 168/4205 | 223/8465 | 1.83e-15 | 6.81e-14 | 3.49e-14 | 168 |
| hsa05418211 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
| hsa015247 | Esophagus | ESCC | Platinum drug resistance | 56/4205 | 73/8465 | 1.85e-06 | 1.13e-05 | 5.78e-06 | 56 |
| hsa0048018 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
| hsa0522518 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
| hsa05208310 | Esophagus | ESCC | Chemical carcinogenesis - reactive oxygen species | 168/4205 | 223/8465 | 1.83e-15 | 6.81e-14 | 3.49e-14 | 168 |
| hsa05418310 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
| hsa0152414 | Esophagus | ESCC | Platinum drug resistance | 56/4205 | 73/8465 | 1.85e-06 | 1.13e-05 | 5.78e-06 | 56 |
| hsa0048019 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
| hsa0522519 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GSTM1 | SNV | Missense_Mutation | novel | c.629N>T | p.Ser210Leu | p.S210L | P09488 | protein_coding | tolerated(0.19) | benign(0.043) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
| GSTM1 | SNV | Missense_Mutation | c.457N>G | p.Ile153Val | p.I153V | P09488 | protein_coding | tolerated(0.11) | probably_damaging(0.957) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| GSTM1 | SNV | Missense_Mutation | c.9G>T | p.Met3Ile | p.M3I | P09488 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| GSTM1 | SNV | Missense_Mutation | novel | c.359N>A | p.Phe120Tyr | p.F120Y | P09488 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-AA-A01I-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| GSTM1 | SNV | Missense_Mutation | c.368N>G | p.Leu123Arg | p.L123R | P09488 | protein_coding | tolerated(0.09) | probably_damaging(0.999) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
| GSTM1 | SNV | Missense_Mutation | rs781192005 | c.286C>T | p.Arg96Cys | p.R96C | P09488 | protein_coding | deleterious(0.01) | benign(0.024) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
| GSTM1 | SNV | Missense_Mutation | rs376564748 | c.53N>A | p.Arg18His | p.R18H | P09488 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GSTM1 | SNV | Missense_Mutation | novel | c.317N>G | p.Asp106Gly | p.D106G | P09488 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| GSTM1 | SNV | Missense_Mutation | novel | c.269N>G | p.Thr90Arg | p.T90R | P09488 | protein_coding | deleterious(0.01) | possibly_damaging(0.636) | TCGA-UF-A7JD-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 2944 | GSTM1 | DRUGGABLE GENOME, ENZYME | doxorubicin | DOXORUBICIN | 23323945 | |
| 2944 | GSTM1 | DRUGGABLE GENOME, ENZYME | CAROTENOID | 15095308 | ||
| 2944 | GSTM1 | DRUGGABLE GENOME, ENZYME | anthracyclines and related substances | 27785604 | ||
| 2944 | GSTM1 | DRUGGABLE GENOME, ENZYME | busulfan | BUSULFAN | 23677058 | |
| 2944 | GSTM1 | DRUGGABLE GENOME, ENZYME | NITROGLYCERIN | NITROGLYCERIN | 2110160 | |
| 2944 | GSTM1 | DRUGGABLE GENOME, ENZYME | XANTHOPHYLLS | 15355982 | ||
| 2944 | GSTM1 | DRUGGABLE GENOME, ENZYME | PREDNISONE | PREDNISONE | 11186134 | |
| 2944 | GSTM1 | DRUGGABLE GENOME, ENZYME | paclitaxel | PACLITAXEL | 26803611 | |
| 2944 | GSTM1 | DRUGGABLE GENOME, ENZYME | DICUMAROL | DICUMAROL | 15044619 | |
| 2944 | GSTM1 | DRUGGABLE GENOME, ENZYME | TROGLITAZONE | TROGLITAZONE | 12732844 |
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