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Gene: GSTCD |
Gene summary for GSTCD |
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Gene information | Species | Human | Gene symbol | GSTCD | Gene ID | 79807 |
Gene name | glutathione S-transferase C-terminal domain containing | |
Gene Alias | GSTCD | |
Cytomap | 4q24 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q8NEC7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79807 | GSTCD | CCI_1 | Human | Cervix | CC | 1.00e-04 | 5.34e-01 | 0.528 |
79807 | GSTCD | CCI_2 | Human | Cervix | CC | 9.30e-10 | 7.86e-01 | 0.5249 |
79807 | GSTCD | CCI_3 | Human | Cervix | CC | 5.28e-05 | 4.44e-01 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GSTCD | SNV | Missense_Mutation | novel | c.1514N>A | p.Gly505Glu | p.G505E | Q8NEC7 | protein_coding | tolerated(0.07) | probably_damaging(0.994) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
GSTCD | SNV | Missense_Mutation | novel | c.572A>C | p.Asn191Thr | p.N191T | Q8NEC7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GSTCD | SNV | Missense_Mutation | c.352G>A | p.Glu118Lys | p.E118K | Q8NEC7 | protein_coding | tolerated(0.21) | benign(0.07) | TCGA-GM-A2DO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR | |
GSTCD | SNV | Missense_Mutation | c.553N>A | p.Glu185Lys | p.E185K | Q8NEC7 | protein_coding | tolerated(0.24) | possibly_damaging(0.794) | TCGA-EK-A3GM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
GSTCD | SNV | Missense_Mutation | novel | c.1210N>A | p.Val404Ile | p.V404I | Q8NEC7 | protein_coding | tolerated(0.13) | benign(0) | TCGA-VS-A8EH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
GSTCD | SNV | Missense_Mutation | c.1555N>C | p.Ala519Pro | p.A519P | Q8NEC7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3844-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
GSTCD | SNV | Missense_Mutation | rs753620399 | c.1259N>A | p.Arg420Gln | p.R420Q | Q8NEC7 | protein_coding | deleterious(0.01) | possibly_damaging(0.797) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSTCD | SNV | Missense_Mutation | rs763673144 | c.1650C>A | p.Phe550Leu | p.F550L | Q8NEC7 | protein_coding | tolerated(0.38) | benign(0.019) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
GSTCD | SNV | Missense_Mutation | c.632N>T | p.Pro211Leu | p.P211L | Q8NEC7 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
GSTCD | SNV | Missense_Mutation | c.1168N>C | p.Phe390Leu | p.F390L | Q8NEC7 | protein_coding | tolerated(0.22) | possibly_damaging(0.505) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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