Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: GSPT1

Gene summary for GSPT1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

GSPT1

Gene ID

2935

Gene nameG1 to S phase transition 1
Gene Alias551G9.2
Cytomap16p13.13
Gene Typeprotein-coding
GO ID

GO:0000082

UniProtAcc

P15170


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
2935GSPT1HTA11_3410_2000001011HumanColorectumAD4.47e-05-3.52e-010.0155
2935GSPT1HTA11_2487_2000001011HumanColorectumSER4.38e-02-3.49e-01-0.1808
2935GSPT1HTA11_99999974143_84620HumanColorectumMSS2.43e-02-2.89e-010.3005
2935GSPT1A015-C-203HumanColorectumFAP1.16e-25-4.39e-01-0.1294
2935GSPT1A015-C-204HumanColorectumFAP3.99e-04-2.56e-01-0.0228
2935GSPT1A014-C-040HumanColorectumFAP3.77e-02-2.05e-01-0.1184
2935GSPT1A002-C-201HumanColorectumFAP6.16e-09-1.97e-010.0324
2935GSPT1A002-C-203HumanColorectumFAP1.81e-05-1.77e-010.2786
2935GSPT1A001-C-119HumanColorectumFAP1.68e-05-2.98e-01-0.1557
2935GSPT1A001-C-108HumanColorectumFAP5.26e-16-3.28e-01-0.0272
2935GSPT1A002-C-205HumanColorectumFAP2.05e-16-3.20e-01-0.1236
2935GSPT1A015-C-005HumanColorectumFAP1.12e-02-2.38e-01-0.0336
2935GSPT1A015-C-006HumanColorectumFAP2.07e-11-4.40e-01-0.0994
2935GSPT1A015-C-106HumanColorectumFAP2.63e-17-3.80e-01-0.0511
2935GSPT1A002-C-114HumanColorectumFAP8.45e-17-4.03e-01-0.1561
2935GSPT1A015-C-104HumanColorectumFAP1.41e-26-3.23e-01-0.1899
2935GSPT1A001-C-014HumanColorectumFAP1.17e-11-1.99e-010.0135
2935GSPT1A002-C-016HumanColorectumFAP6.15e-21-2.67e-010.0521
2935GSPT1A015-C-002HumanColorectumFAP3.28e-10-3.89e-01-0.0763
2935GSPT1A001-C-203HumanColorectumFAP5.11e-09-1.95e-01-0.0481
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0002181ColorectumADcytoplasmic translation109/3918148/187233.40e-432.13e-39109
GO:0022411ColorectumADcellular component disassembly147/3918443/187238.53e-106.76e-08147
GO:0006401ColorectumADRNA catabolic process102/3918278/187238.64e-106.76e-08102
GO:0044270ColorectumADcellular nitrogen compound catabolic process147/3918451/187233.35e-092.23e-07147
GO:0046700ColorectumADheterocycle catabolic process145/3918445/187234.37e-092.84e-07145
GO:0006402ColorectumADmRNA catabolic process87/3918232/187234.40e-092.84e-0787
GO:0034655ColorectumADnucleobase-containing compound catabolic process133/3918407/187231.56e-089.12e-07133
GO:0019439ColorectumADaromatic compound catabolic process146/3918467/187237.48e-083.84e-06146
GO:1901361ColorectumADorganic cyclic compound catabolic process153/3918495/187238.23e-084.18e-06153
GO:0032984ColorectumADprotein-containing complex disassembly81/3918224/187239.41e-084.65e-0681
GO:0006417ColorectumADregulation of translation141/3918468/187231.32e-064.22e-05141
GO:0000956ColorectumADnuclear-transcribed mRNA catabolic process40/3918112/187232.11e-042.79e-0340
GO:0043244ColorectumADregulation of protein-containing complex disassembly41/3918121/187236.22e-046.48e-0341
GO:0043624ColorectumADcellular protein complex disassembly45/3918136/187236.24e-046.48e-0345
GO:00021811ColorectumSERcytoplasmic translation102/2897148/187231.38e-488.49e-45102
GO:00224111ColorectumSERcellular component disassembly114/2897443/187231.17e-089.59e-07114
GO:00329841ColorectumSERprotein-containing complex disassembly61/2897224/187234.17e-061.60e-0461
GO:00442701ColorectumSERcellular nitrogen compound catabolic process99/2897451/187231.46e-042.86e-0399
GO:00467001ColorectumSERheterocycle catabolic process97/2897445/187232.20e-043.89e-0397
GO:00436241ColorectumSERcellular protein complex disassembly37/2897136/187233.08e-045.00e-0337
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa03015ColorectumADmRNA surveillance pathway35/209297/84657.95e-033.13e-022.00e-0235
hsa030151ColorectumADmRNA surveillance pathway35/209297/84657.95e-033.13e-022.00e-0235
hsa030152ColorectumFAPmRNA surveillance pathway26/140497/84657.11e-032.64e-021.60e-0226
hsa030153ColorectumFAPmRNA surveillance pathway26/140497/84657.11e-032.64e-021.60e-0226
hsa030159EsophagusHGINmRNA surveillance pathway30/138397/84652.48e-042.69e-032.14e-0330
hsa0301514EsophagusHGINmRNA surveillance pathway30/138397/84652.48e-042.69e-032.14e-0330
hsa0301524EsophagusESCCmRNA surveillance pathway72/420597/84656.12e-074.10e-062.10e-0672
hsa0301534EsophagusESCCmRNA surveillance pathway72/420597/84656.12e-074.10e-062.10e-0672
hsa030154LiverCirrhoticmRNA surveillance pathway46/253097/84651.92e-041.30e-038.03e-0446
hsa0301511LiverCirrhoticmRNA surveillance pathway46/253097/84651.92e-041.30e-038.03e-0446
hsa0301521LiverHCCmRNA surveillance pathway66/402097/84653.16e-051.88e-041.04e-0466
hsa0301531LiverHCCmRNA surveillance pathway66/402097/84653.16e-051.88e-041.04e-0466
hsa030158Oral cavityOSCCmRNA surveillance pathway75/370497/84651.30e-112.01e-101.02e-1075
hsa0301513Oral cavityOSCCmRNA surveillance pathway75/370497/84651.30e-112.01e-101.02e-1075
hsa0301523Oral cavityLPmRNA surveillance pathway50/241897/84651.39e-061.50e-059.66e-0650
hsa0301533Oral cavityLPmRNA surveillance pathway50/241897/84651.39e-061.50e-059.66e-0650
hsa030155ProstateBPHmRNA surveillance pathway32/171897/84652.20e-038.63e-035.34e-0332
hsa0301512ProstateBPHmRNA surveillance pathway32/171897/84652.20e-038.63e-035.34e-0332
hsa0301522ProstateTumormRNA surveillance pathway33/179197/84652.18e-038.60e-035.33e-0333
hsa0301532ProstateTumormRNA surveillance pathway33/179197/84652.18e-038.60e-035.33e-0333
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
GSPT1SNVMissense_Mutationc.1487C>Ap.Pro496Glnp.P496QP15170protein_codingdeleterious(0.04)probably_damaging(0.96)TCGA-A7-A0DB-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
GSPT1SNVMissense_Mutationc.1162T>Cp.Phe388Leup.F388LP15170protein_codingdeleterious(0.02)probably_damaging(0.979)TCGA-A8-A09I-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
GSPT1SNVMissense_Mutationc.529N>Tp.Asp177Tyrp.D177YP15170protein_codingdeleterious(0)possibly_damaging(0.882)TCGA-AO-A124-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
GSPT1SNVMissense_Mutationc.728N>Tp.Thr243Metp.T243MP15170protein_codingdeleterious(0.02)possibly_damaging(0.769)TCGA-B6-A0RL-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
GSPT1SNVMissense_Mutationc.1528G>Cp.Glu510Glnp.E510QP15170protein_codingdeleterious(0)probably_damaging(0.971)TCGA-BH-A0DZ-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydocetaxelSD
GSPT1SNVMissense_Mutationc.1408N>Tp.Leu470Phep.L470FP15170protein_codingdeleterious(0.02)benign(0.309)TCGA-C8-A12X-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
GSPT1SNVMissense_Mutationnovelc.1286N>Gp.Leu429Trpp.L429WP15170protein_codingdeleterious(0)probably_damaging(0.994)TCGA-GI-A2C9-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificSD
GSPT1SNVMissense_Mutationnovelc.921N>Ap.Met307Ilep.M307IP15170protein_codingdeleterious(0)probably_damaging(0.999)TCGA-S3-AA14-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
GSPT1SNVMissense_Mutationc.1522G>Ap.Glu508Lysp.E508KP15170protein_codingdeleterious(0)probably_damaging(0.988)TCGA-FU-A3TX-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
GSPT1insertionNonsense_Mutationnovelc.1015_1016insCCTATGAGTp.Arg339delinsThrTyrGluTerp.R339delinsTYE*P15170protein_codingTCGA-DS-A1OC-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapygemcitabineSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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