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Gene: GSG1 |
Gene summary for GSG1 |
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Gene information | Species | Human | Gene symbol | GSG1 | Gene ID | 83445 |
Gene name | germ cell associated 1 | |
Gene Alias | GSG1 | |
Cytomap | 12p13.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | F1T0A1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83445 | GSG1 | HCC1 | Human | Liver | HCC | 1.33e-05 | 4.65e-01 | 0.5336 |
83445 | GSG1 | HCC2 | Human | Liver | HCC | 3.91e-14 | 1.20e+00 | 0.5341 |
83445 | GSG1 | HCC5 | Human | Liver | HCC | 2.42e-07 | 9.11e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GSG1 | SNV | Missense_Mutation | novel | c.671N>G | p.Ala224Gly | p.A224G | Q2KHT4 | protein_coding | deleterious(0) | possibly_damaging(0.61) | TCGA-BH-A0HU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
GSG1 | SNV | Missense_Mutation | novel | c.671C>G | p.Ala224Gly | p.A224G | Q2KHT4 | protein_coding | deleterious(0) | possibly_damaging(0.61) | TCGA-BH-A1FH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
GSG1 | deletion | Frame_Shift_Del | novel | c.451delN | p.Ile151SerfsTer12 | p.I151Sfs*12 | Q2KHT4 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GSG1 | deletion | Frame_Shift_Del | novel | c.195delN | p.Gly66ValfsTer97 | p.G66Vfs*97 | Q2KHT4 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GSG1 | SNV | Missense_Mutation | novel | c.181C>T | p.Pro61Ser | p.P61S | Q2KHT4 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
GSG1 | SNV | Missense_Mutation | novel | c.653N>C | p.Val218Ala | p.V218A | Q2KHT4 | protein_coding | tolerated(0.75) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSG1 | SNV | Missense_Mutation | rs750502868 | c.445N>G | p.Thr149Ala | p.T149A | Q2KHT4 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
GSG1 | SNV | Missense_Mutation | c.482T>A | p.Leu161Gln | p.L161Q | Q2KHT4 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GSG1 | SNV | Missense_Mutation | rs536441717 | c.310N>T | p.Arg104Trp | p.R104W | Q2KHT4 | protein_coding | deleterious(0) | possibly_damaging(0.857) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSG1 | SNV | Missense_Mutation | novel | c.205G>A | p.Ala69Thr | p.A69T | Q2KHT4 | protein_coding | tolerated(0.97) | benign(0.007) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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