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Gene: GSDME |
Gene summary for GSDME |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GSDME | Gene ID | 1687 |
| Gene name | gasdermin E | |
| Gene Alias | DFNA5 | |
| Cytomap | 7p15.3 | |
| Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024RA58 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 1687 | GSDME | male-WTA | Human | Thyroid | PTC | 2.74e-06 | 1.27e-01 | 0.1037 |
| 1687 | GSDME | PTC05 | Human | Thyroid | PTC | 7.54e-06 | 2.50e-01 | 0.2065 |
| 1687 | GSDME | PTC06 | Human | Thyroid | PTC | 3.64e-11 | 2.84e-01 | 0.2057 |
| 1687 | GSDME | PTC07 | Human | Thyroid | PTC | 2.48e-11 | 2.18e-01 | 0.2044 |
| 1687 | GSDME | ATC09 | Human | Thyroid | ATC | 3.35e-21 | 5.90e-01 | 0.2871 |
| 1687 | GSDME | ATC12 | Human | Thyroid | ATC | 2.31e-12 | 2.74e-01 | 0.34 |
| 1687 | GSDME | ATC13 | Human | Thyroid | ATC | 9.50e-14 | 2.72e-01 | 0.34 |
| 1687 | GSDME | ATC1 | Human | Thyroid | ATC | 2.71e-20 | 6.15e-01 | 0.2878 |
| 1687 | GSDME | ATC2 | Human | Thyroid | ATC | 3.34e-11 | 5.38e-01 | 0.34 |
| 1687 | GSDME | ATC4 | Human | Thyroid | ATC | 1.23e-16 | 3.93e-01 | 0.34 |
| 1687 | GSDME | ATC5 | Human | Thyroid | ATC | 1.90e-14 | 2.98e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:2001233113 | Thyroid | PTC | regulation of apoptotic signaling pathway | 197/5968 | 356/18723 | 2.58e-20 | 3.69e-18 | 197 |
| GO:0097193113 | Thyroid | PTC | intrinsic apoptotic signaling pathway | 164/5968 | 288/18723 | 9.17e-19 | 1.09e-16 | 164 |
| GO:2001242113 | Thyroid | PTC | regulation of intrinsic apoptotic signaling pathway | 99/5968 | 164/18723 | 4.74e-14 | 2.79e-12 | 99 |
| GO:2001235112 | Thyroid | PTC | positive regulation of apoptotic signaling pathway | 69/5968 | 126/18723 | 8.51e-08 | 1.73e-06 | 69 |
| GO:000961520 | Thyroid | PTC | response to virus | 162/5968 | 367/18723 | 4.52e-07 | 7.41e-06 | 162 |
| GO:2001244110 | Thyroid | PTC | positive regulation of intrinsic apoptotic signaling pathway | 33/5968 | 58/18723 | 7.13e-05 | 6.19e-04 | 33 |
| GO:0034612111 | Thyroid | PTC | response to tumor necrosis factor | 109/5968 | 253/18723 | 1.08e-04 | 8.69e-04 | 109 |
| GO:0071356111 | Thyroid | PTC | cellular response to tumor necrosis factor | 96/5968 | 229/18723 | 8.24e-04 | 5.10e-03 | 96 |
| GO:00985869 | Thyroid | PTC | cellular response to virus | 41/5968 | 84/18723 | 8.84e-04 | 5.40e-03 | 41 |
| GO:00702656 | Thyroid | PTC | necrotic cell death | 29/5968 | 62/18723 | 9.96e-03 | 4.07e-02 | 29 |
| GO:200123335 | Thyroid | ATC | regulation of apoptotic signaling pathway | 206/6293 | 356/18723 | 2.81e-21 | 5.92e-19 | 206 |
| GO:009719335 | Thyroid | ATC | intrinsic apoptotic signaling pathway | 171/6293 | 288/18723 | 1.86e-19 | 2.67e-17 | 171 |
| GO:200124233 | Thyroid | ATC | regulation of intrinsic apoptotic signaling pathway | 103/6293 | 164/18723 | 1.67e-14 | 9.77e-13 | 103 |
| GO:200123528 | Thyroid | ATC | positive regulation of apoptotic signaling pathway | 73/6293 | 126/18723 | 1.74e-08 | 3.47e-07 | 73 |
| GO:0009615111 | Thyroid | ATC | response to virus | 173/6293 | 367/18723 | 4.23e-08 | 7.71e-07 | 173 |
| GO:003461228 | Thyroid | ATC | response to tumor necrosis factor | 116/6293 | 253/18723 | 3.22e-05 | 2.68e-04 | 116 |
| GO:200124433 | Thyroid | ATC | positive regulation of intrinsic apoptotic signaling pathway | 34/6293 | 58/18723 | 8.05e-05 | 6.03e-04 | 34 |
| GO:009858615 | Thyroid | ATC | cellular response to virus | 44/6293 | 84/18723 | 2.94e-04 | 1.87e-03 | 44 |
| GO:007135627 | Thyroid | ATC | cellular response to tumor necrosis factor | 102/6293 | 229/18723 | 3.52e-04 | 2.18e-03 | 102 |
| GO:007026512 | Thyroid | ATC | necrotic cell death | 30/6293 | 62/18723 | 1.12e-02 | 4.00e-02 | 30 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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