![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GSDMB |
Gene summary for GSDMB |
![]() |
Gene information | Species | Human | Gene symbol | GSDMB | Gene ID | 55876 |
Gene name | gasdermin B | |
Gene Alias | GSDMB-1 | |
Cytomap | 17q21.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q8TAX9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55876 | GSDMB | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.16e-05 | 7.05e-02 | 0.0155 |
55876 | GSDMB | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.75e-07 | 4.46e-01 | -0.1808 |
55876 | GSDMB | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.03e-11 | 6.13e-01 | -0.0811 |
55876 | GSDMB | HTA11_78_2000001011 | Human | Colorectum | AD | 2.33e-07 | 4.57e-01 | -0.1088 |
55876 | GSDMB | HTA11_347_2000001011 | Human | Colorectum | AD | 1.08e-06 | 4.05e-01 | -0.1954 |
55876 | GSDMB | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.90e-05 | 4.61e-01 | -0.1207 |
55876 | GSDMB | HTA11_696_2000001011 | Human | Colorectum | AD | 2.08e-07 | 4.00e-01 | -0.1464 |
55876 | GSDMB | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.02e-12 | 6.62e-01 | -0.059 |
55876 | GSDMB | HTA11_866_3004761011 | Human | Colorectum | AD | 1.42e-02 | 2.36e-01 | 0.096 |
55876 | GSDMB | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.41e-07 | 5.42e-01 | 0.294 |
55876 | GSDMB | A015-C-203 | Human | Colorectum | FAP | 1.08e-02 | 7.71e-03 | -0.1294 |
55876 | GSDMB | A015-C-104 | Human | Colorectum | FAP | 1.18e-02 | -4.74e-02 | -0.1899 |
55876 | GSDMB | A002-C-116 | Human | Colorectum | FAP | 6.42e-05 | -1.01e-01 | -0.0452 |
55876 | GSDMB | F034 | Human | Colorectum | FAP | 2.12e-02 | -3.76e-02 | -0.0665 |
55876 | GSDMB | NAFLD1 | Human | Liver | NAFLD | 1.45e-08 | 6.76e-01 | -0.04 |
55876 | GSDMB | HCC1_Meng | Human | Liver | HCC | 3.37e-09 | -4.12e-02 | 0.0246 |
55876 | GSDMB | HCC2_Meng | Human | Liver | HCC | 3.74e-15 | 1.44e-01 | 0.0107 |
55876 | GSDMB | HCC1 | Human | Liver | HCC | 9.89e-03 | 2.18e+00 | 0.5336 |
55876 | GSDMB | S029 | Human | Liver | HCC | 2.99e-07 | 5.30e-01 | 0.2581 |
55876 | GSDMB | C21 | Human | Oral cavity | OSCC | 7.33e-05 | 2.31e-01 | 0.2678 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GSDMB | SNV | Missense_Mutation | novel | c.766N>A | p.Glu256Lys | p.E256K | Q8TAX9 | protein_coding | tolerated(0.07) | possibly_damaging(0.556) | TCGA-A2-A0EM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
GSDMB | SNV | Missense_Mutation | novel | c.725N>C | p.Leu242Ser | p.L242S | Q8TAX9 | protein_coding | tolerated(0.16) | benign(0.29) | TCGA-A2-A4S2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | CR |
GSDMB | SNV | Missense_Mutation | c.982N>C | p.Glu328Gln | p.E328Q | Q8TAX9 | protein_coding | tolerated(0.13) | benign(0.395) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GSDMB | SNV | Missense_Mutation | novel | c.778G>A | p.Asp260Asn | p.D260N | Q8TAX9 | protein_coding | deleterious(0.04) | benign(0.103) | TCGA-BH-A1EV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
GSDMB | insertion | Nonsense_Mutation | novel | c.154_155insGAA | p.Tyr52delinsTer | p.Y52delins* | Q8TAX9 | protein_coding | TCGA-A8-A07F-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GSDMB | insertion | Nonsense_Mutation | novel | c.153_154insCATCCTGGCTAACACAG | p.Tyr52HisfsTer4 | p.Y52Hfs*4 | Q8TAX9 | protein_coding | TCGA-A8-A07F-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GSDMB | SNV | Missense_Mutation | novel | c.109N>C | p.Phe37Leu | p.F37L | Q8TAX9 | protein_coding | tolerated(0.3) | benign(0.042) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GSDMB | SNV | Missense_Mutation | c.460N>G | p.Asn154Asp | p.N154D | Q8TAX9 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3982-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
GSDMB | SNV | Missense_Mutation | novel | c.971N>A | p.Gly324Glu | p.G324E | Q8TAX9 | protein_coding | deleterious(0.03) | possibly_damaging(0.64) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSDMB | SNV | Missense_Mutation | novel | c.349N>C | p.Lys117Gln | p.K117Q | Q8TAX9 | protein_coding | tolerated(0.44) | benign(0.006) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |