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Gene: GRB10 |
Gene summary for GRB10 |
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Gene information | Species | Human | Gene symbol | GRB10 | Gene ID | 2887 |
Gene name | growth factor receptor bound protein 10 | |
Gene Alias | GRB-IR | |
Cytomap | 7p12.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q13322 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2887 | GRB10 | NAFLD1 | Human | Liver | NAFLD | 2.01e-07 | 7.71e-01 | -0.04 |
2887 | GRB10 | S41 | Human | Liver | Cirrhotic | 3.86e-02 | 5.11e-01 | -0.0343 |
2887 | GRB10 | S43 | Human | Liver | Cirrhotic | 7.97e-07 | -3.12e-02 | -0.0187 |
2887 | GRB10 | HCC1_Meng | Human | Liver | HCC | 8.36e-44 | -1.01e-01 | 0.0246 |
2887 | GRB10 | HCC2_Meng | Human | Liver | HCC | 6.81e-03 | -1.34e-01 | 0.0107 |
2887 | GRB10 | HCC1 | Human | Liver | HCC | 8.91e-03 | 3.52e+00 | 0.5336 |
2887 | GRB10 | HCC2 | Human | Liver | HCC | 1.55e-09 | 3.19e+00 | 0.5341 |
2887 | GRB10 | HCC5 | Human | Liver | HCC | 1.29e-02 | 8.10e-01 | 0.4932 |
2887 | GRB10 | Pt13.a | Human | Liver | HCC | 7.69e-03 | -1.77e-01 | 0.021 |
2887 | GRB10 | S014 | Human | Liver | HCC | 1.52e-09 | 5.92e-01 | 0.2254 |
2887 | GRB10 | S015 | Human | Liver | HCC | 7.78e-11 | 8.05e-01 | 0.2375 |
2887 | GRB10 | S016 | Human | Liver | HCC | 1.24e-12 | 6.08e-01 | 0.2243 |
2887 | GRB10 | S027 | Human | Liver | HCC | 8.39e-14 | 1.89e+00 | 0.2446 |
2887 | GRB10 | S028 | Human | Liver | HCC | 4.40e-21 | 1.44e+00 | 0.2503 |
2887 | GRB10 | S029 | Human | Liver | HCC | 1.77e-17 | 1.29e+00 | 0.2581 |
2887 | GRB10 | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.44e-03 | 6.52e-01 | 0.3371 |
2887 | GRB10 | RNA-P17T-P17T-6 | Human | Lung | IAC | 7.91e-03 | 5.96e-01 | 0.3385 |
2887 | GRB10 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 9.23e-03 | 3.59e-01 | -0.2119 |
2887 | GRB10 | RNA-P3T-P3T-4 | Human | Lung | IAC | 4.38e-02 | 3.90e-01 | 0.1859 |
2887 | GRB10 | 047563_1562-all-cells | Human | Prostate | BPH | 2.19e-04 | 2.60e-01 | 0.0791 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00713755 | Liver | NAFLD | cellular response to peptide hormone stimulus | 65/1882 | 290/18723 | 3.95e-10 | 9.62e-08 | 65 |
GO:19016536 | Liver | NAFLD | cellular response to peptide | 71/1882 | 359/18723 | 1.82e-08 | 2.09e-06 | 71 |
GO:00328695 | Liver | NAFLD | cellular response to insulin stimulus | 47/1882 | 203/18723 | 3.60e-08 | 3.63e-06 | 47 |
GO:00434346 | Liver | NAFLD | response to peptide hormone | 76/1882 | 414/18723 | 1.51e-07 | 1.09e-05 | 76 |
GO:00328685 | Liver | NAFLD | response to insulin | 53/1882 | 264/18723 | 6.99e-07 | 3.95e-05 | 53 |
GO:00423267 | Liver | NAFLD | negative regulation of phosphorylation | 67/1882 | 385/18723 | 5.49e-06 | 1.98e-04 | 67 |
GO:00160555 | Liver | NAFLD | Wnt signaling pathway | 74/1882 | 444/18723 | 8.98e-06 | 2.96e-04 | 74 |
GO:01987385 | Liver | NAFLD | cell-cell signaling by wnt | 74/1882 | 446/18723 | 1.05e-05 | 3.33e-04 | 74 |
GO:00459367 | Liver | NAFLD | negative regulation of phosphate metabolic process | 73/1882 | 441/18723 | 1.31e-05 | 3.93e-04 | 73 |
GO:00105637 | Liver | NAFLD | negative regulation of phosphorus metabolic process | 73/1882 | 442/18723 | 1.42e-05 | 4.17e-04 | 73 |
GO:00082863 | Liver | NAFLD | insulin receptor signaling pathway | 27/1882 | 116/18723 | 2.50e-05 | 6.76e-04 | 27 |
GO:00301115 | Liver | NAFLD | regulation of Wnt signaling pathway | 57/1882 | 328/18723 | 2.79e-05 | 7.46e-04 | 57 |
GO:00463241 | Liver | NAFLD | regulation of glucose import | 16/1882 | 59/18723 | 1.68e-04 | 3.06e-03 | 16 |
GO:00108271 | Liver | NAFLD | regulation of glucose transmembrane transport | 18/1882 | 77/18723 | 5.06e-04 | 7.15e-03 | 18 |
GO:0046626 | Liver | NAFLD | regulation of insulin receptor signaling pathway | 16/1882 | 66/18723 | 6.66e-04 | 8.61e-03 | 16 |
GO:1900076 | Liver | NAFLD | regulation of cellular response to insulin stimulus | 15/1882 | 64/18723 | 1.40e-03 | 1.57e-02 | 15 |
GO:19908452 | Liver | NAFLD | adaptive thermogenesis | 28/1882 | 157/18723 | 1.91e-03 | 1.93e-02 | 28 |
GO:00463231 | Liver | NAFLD | glucose import | 16/1882 | 74/18723 | 2.43e-03 | 2.27e-02 | 16 |
GO:00480091 | Liver | NAFLD | insulin-like growth factor receptor signaling pathway | 10/1882 | 37/18723 | 2.82e-03 | 2.56e-02 | 10 |
GO:00016592 | Liver | NAFLD | temperature homeostasis | 29/1882 | 174/18723 | 4.48e-03 | 3.61e-02 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041502 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0415011 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRB10 | SNV | Missense_Mutation | c.1144N>A | p.Glu382Lys | p.E382K | Q13322 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GRB10 | SNV | Missense_Mutation | rs373960643 | c.1343N>T | p.Pro448Leu | p.P448L | Q13322 | protein_coding | deleterious(0.02) | possibly_damaging(0.894) | TCGA-E2-A15C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
GRB10 | SNV | Missense_Mutation | novel | c.406N>G | p.Pro136Ala | p.P136A | Q13322 | protein_coding | deleterious(0.01) | possibly_damaging(0.831) | TCGA-OL-A5RU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
GRB10 | insertion | Nonsense_Mutation | novel | c.1398_1399insCCACAGGATCATTAAACAGCAAGGGCTCGTGGATG | p.Thr467ProfsTer5 | p.T467Pfs*5 | Q13322 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GRB10 | SNV | Missense_Mutation | c.1369G>A | p.Glu457Lys | p.E457K | Q13322 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-EA-A50E-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
GRB10 | SNV | Missense_Mutation | novel | c.1486N>A | p.Gly496Arg | p.G496R | Q13322 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-ZJ-AAXF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GRB10 | SNV | Missense_Mutation | rs555920373 | c.824G>A | p.Gly275Asp | p.G275D | Q13322 | protein_coding | tolerated(0.18) | benign(0.024) | TCGA-A6-6648-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD |
GRB10 | SNV | Missense_Mutation | rs778877926 | c.467N>T | p.Pro156Leu | p.P156L | Q13322 | protein_coding | tolerated(0.19) | benign(0.01) | TCGA-AA-3526-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GRB10 | SNV | Missense_Mutation | novel | c.848N>G | p.Asn283Ser | p.N283S | Q13322 | protein_coding | tolerated(0.06) | benign(0.295) | TCGA-AA-3538-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRB10 | SNV | Missense_Mutation | rs745633042 | c.748N>A | p.Ala250Thr | p.A250T | Q13322 | protein_coding | deleterious(0) | possibly_damaging(0.843) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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