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Gene: GRAMD2B |
Gene summary for GRAMD2B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GRAMD2B | Gene ID | 65983 |
| Gene name | GRAM domain containing 2B | |
| Gene Alias | GRAMD3 | |
| Cytomap | 5q23.2 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96HH9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 65983 | GRAMD2B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.46e-21 | -6.98e-01 | 0.0155 |
| 65983 | GRAMD2B | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.87e-07 | -4.75e-01 | -0.0811 |
| 65983 | GRAMD2B | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.14e-06 | -5.67e-01 | -0.1207 |
| 65983 | GRAMD2B | HTA11_696_2000001011 | Human | Colorectum | AD | 2.99e-11 | -4.33e-01 | -0.1464 |
| 65983 | GRAMD2B | HTA11_866_2000001011 | Human | Colorectum | AD | 3.20e-05 | -3.53e-01 | -0.1001 |
| 65983 | GRAMD2B | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.44e-11 | -4.98e-01 | -0.059 |
| 65983 | GRAMD2B | HTA11_546_2000001011 | Human | Colorectum | AD | 3.30e-03 | -4.55e-01 | -0.0842 |
| 65983 | GRAMD2B | HTA11_866_3004761011 | Human | Colorectum | AD | 4.35e-14 | -6.30e-01 | 0.096 |
| 65983 | GRAMD2B | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.86e-06 | -8.25e-01 | 0.0528 |
| 65983 | GRAMD2B | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.22e-04 | -4.93e-01 | -0.0177 |
| 65983 | GRAMD2B | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.17e-08 | -6.39e-01 | 0.0338 |
| 65983 | GRAMD2B | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.91e-29 | -6.49e-01 | 0.0674 |
| 65983 | GRAMD2B | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.47e-03 | -6.41e-01 | 0.0112 |
| 65983 | GRAMD2B | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.13e-02 | -5.20e-01 | 0.0588 |
| 65983 | GRAMD2B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.20e-62 | -8.96e-01 | 0.294 |
| 65983 | GRAMD2B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.18e-20 | -8.96e-01 | 0.281 |
| 65983 | GRAMD2B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.47e-59 | -8.96e-01 | 0.3859 |
| 65983 | GRAMD2B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.70e-15 | -8.96e-01 | 0.2585 |
| 65983 | GRAMD2B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.40e-57 | -8.96e-01 | 0.3005 |
| 65983 | GRAMD2B | F007 | Human | Colorectum | FAP | 1.66e-04 | -5.10e-01 | 0.1176 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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