Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: GPX2

Gene summary for GPX2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

GPX2

Gene ID

2877

Gene nameglutathione peroxidase 2
Gene AliasGI-GPx
Cytomap14q23.3
Gene Typeprotein-coding
GO ID

GO:0006091

UniProtAcc

P18283


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
2877GPX2CA_HPV_2HumanCervixCC8.57e-153.15e-010.0391
2877GPX2CA_HPV_3HumanCervixCC1.30e-122.92e-010.0414
2877GPX2N_HPV_2HumanCervixN_HPV1.75e-081.97e-01-0.0131
2877GPX2TumorHumanCervixCC2.67e-741.08e+000.1241
2877GPX2sample3HumanCervixCC1.66e-659.33e-010.1387
2877GPX2T3HumanCervixCC7.06e-699.65e-010.1389
2877GPX2HTA11_3410_2000001011HumanColorectumAD1.19e-155.12e-010.0155
2877GPX2HTA11_1938_2000001011HumanColorectumAD4.77e-211.06e+00-0.0811
2877GPX2HTA11_78_2000001011HumanColorectumAD1.26e-054.27e-01-0.1088
2877GPX2HTA11_347_2000001011HumanColorectumAD1.16e-288.69e-01-0.1954
2877GPX2HTA11_411_2000001011HumanColorectumSER3.48e-071.09e+00-0.2602
2877GPX2HTA11_2112_2000001011HumanColorectumSER3.46e-048.67e-01-0.2196
2877GPX2HTA11_3361_2000001011HumanColorectumAD1.17e-079.38e-01-0.1207
2877GPX2HTA11_696_2000001011HumanColorectumAD3.52e-201.12e+00-0.1464
2877GPX2HTA11_866_2000001011HumanColorectumAD1.39e-077.60e-01-0.1001
2877GPX2HTA11_1391_2000001011HumanColorectumAD1.03e-362.26e+00-0.059
2877GPX2HTA11_2992_2000001011HumanColorectumSER1.39e-069.96e-01-0.1706
2877GPX2HTA11_5212_2000001011HumanColorectumAD2.13e-046.59e-01-0.2061
2877GPX2HTA11_5216_2000001011HumanColorectumSER2.34e-081.03e+00-0.1462
2877GPX2HTA11_546_2000001011HumanColorectumAD1.43e-181.16e+00-0.0842
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00229009CervixCCelectron transport chain53/2311175/187232.23e-103.43e-0853
GO:000697910CervixCCresponse to oxidative stress102/2311446/187232.99e-104.36e-08102
GO:00060919CervixCCgeneration of precursor metabolites and energy105/2311490/187237.40e-096.61e-07105
GO:00988699CervixCCcellular oxidant detoxification30/2311101/187232.72e-067.93e-0530
GO:19907489CervixCCcellular detoxification30/2311116/187235.34e-057.94e-0430
GO:00972379CervixCCcellular response to toxic substance31/2311124/187238.09e-051.10e-0331
GO:00096369CervixCCresponse to toxic substance52/2311262/187233.34e-043.52e-0352
GO:00987549CervixCCdetoxification33/2311152/187237.97e-047.00e-0333
GO:000609124CervixN_HPVgeneration of precursor metabolites and energy40/534490/187232.59e-097.88e-0740
GO:000963624CervixN_HPVresponse to toxic substance27/534262/187239.00e-091.71e-0627
GO:002290024CervixN_HPVelectron transport chain21/534175/187232.95e-083.63e-0621
GO:000697925CervixN_HPVresponse to oxidative stress31/534446/187235.10e-061.89e-0431
GO:009886924CervixN_HPVcellular oxidant detoxification13/534101/187235.89e-062.15e-0413
GO:009723724CervixN_HPVcellular response to toxic substance14/534124/187231.22e-054.06e-0414
GO:199074824CervixN_HPVcellular detoxification13/534116/187232.69e-057.30e-0413
GO:009875424CervixN_HPVdetoxification15/534152/187233.05e-058.02e-0415
GO:0006091ColorectumADgeneration of precursor metabolites and energy209/3918490/187233.17e-286.61e-25209
GO:0022900ColorectumADelectron transport chain89/3918175/187231.42e-188.91e-1689
GO:0006979ColorectumADresponse to oxidative stress145/3918446/187235.16e-093.23e-07145
GO:0009636ColorectumADresponse to toxic substance88/3918262/187231.12e-063.72e-0588
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0501618CervixCCHuntington disease94/1267306/84658.49e-133.06e-111.81e-1194
hsa0502218CervixCCPathways of neurodegeneration - multiple diseases128/1267476/84652.87e-129.29e-115.50e-11128
hsa0501418CervixCCAmyotrophic lateral sclerosis103/1267364/84651.79e-114.47e-102.64e-10103
hsa0501619CervixCCHuntington disease94/1267306/84658.49e-133.06e-111.81e-1194
hsa0502219CervixCCPathways of neurodegeneration - multiple diseases128/1267476/84652.87e-129.29e-115.50e-11128
hsa0501419CervixCCAmyotrophic lateral sclerosis103/1267364/84651.79e-114.47e-102.64e-10103
hsa0501444CervixN_HPVAmyotrophic lateral sclerosis41/349364/84653.11e-091.06e-078.26e-0841
hsa0501644CervixN_HPVHuntington disease36/349306/84659.73e-092.65e-072.07e-0736
hsa0502244CervixN_HPVPathways of neurodegeneration - multiple diseases47/349476/84651.48e-083.13e-072.45e-0747
hsa0501454CervixN_HPVAmyotrophic lateral sclerosis41/349364/84653.11e-091.06e-078.26e-0841
hsa0501654CervixN_HPVHuntington disease36/349306/84659.73e-092.65e-072.07e-0736
hsa0502254CervixN_HPVPathways of neurodegeneration - multiple diseases47/349476/84651.48e-083.13e-072.45e-0747
hsa05016ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa05014ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa05022ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa00480ColorectumADGlutathione metabolism23/209257/84656.52e-032.76e-021.76e-0223
hsa050161ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa050141ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa050221ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa004801ColorectumADGlutathione metabolism23/209257/84656.52e-032.76e-021.76e-0223
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
GPX2SNVMissense_Mutationc.243G>Cp.Glu81Aspp.E81DP18283protein_codingdeleterious(0)probably_damaging(0.991)TCGA-B6-A1KI-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
GPX2insertionNonsense_Mutationnovelc.259_260insTATAGTCCAAAACAAATAGATAATTATACp.Lys87IlefsTer?p.K87Ifs*?P18283protein_codingTCGA-BH-A0B4-01Breastbreast invasive carcinomaMale>=65III/IVHormone TherapytamoxiphenSD
GPX2SNVMissense_Mutationnovelc.280N>Ap.Gly94Argp.G94RP18283protein_codingdeleterious(0.03)possibly_damaging(0.839)TCGA-VS-A9U6-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
GPX2SNVMissense_Mutationc.389C>Ap.Pro130Glnp.P130QP18283protein_codingtolerated(0.06)benign(0.419)TCGA-AA-3833-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
GPX2SNVMissense_Mutationc.511N>Ap.Arg171Serp.R171SP18283protein_codingdeleterious(0.04)benign(0.12)TCGA-AD-A5EJ-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
GPX2SNVMissense_Mutationc.485N>Tp.Glu162Valp.E162VP18283protein_codingdeleterious(0)benign(0.044)TCGA-WS-AB45-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
GPX2deletionFrame_Shift_Delrs773382437c.456delNp.Trp152Terp.W152*P18283protein_codingTCGA-AA-3673-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
GPX2SNVMissense_Mutationnovelc.37N>Ap.Ala13Thrp.A13TP18283protein_codingtolerated(0.05)benign(0.238)TCGA-AJ-A3EK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapycarboplatinCR
GPX2SNVMissense_Mutationnovelc.43N>Cp.Ser15Argp.S15RP18283protein_codingtolerated(0.52)benign(0.049)TCGA-AJ-A3NE-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
GPX2SNVMissense_Mutationnovelc.362N>Gp.Asp121Glyp.D121GP18283protein_codingdeleterious(0.04)benign(0.003)TCGA-AP-A1DV-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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