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Gene: GPRC5A |
Gene summary for GPRC5A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GPRC5A | Gene ID | 9052 |
| Gene name | G protein-coupled receptor class C group 5 member A | |
| Gene Alias | GPCR5A | |
| Cytomap | 12p13.1 | |
| Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q8NFJ5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9052 | GPRC5A | GSM4909282 | Human | Breast | IDC | 3.83e-18 | 7.07e-01 | -0.0288 |
| 9052 | GPRC5A | GSM4909290 | Human | Breast | IDC | 4.26e-03 | -2.61e-01 | 0.2096 |
| 9052 | GPRC5A | GSM4909293 | Human | Breast | IDC | 4.54e-03 | 3.01e-01 | 0.1581 |
| 9052 | GPRC5A | GSM4909296 | Human | Breast | IDC | 1.16e-02 | -1.20e-01 | 0.1524 |
| 9052 | GPRC5A | GSM4909304 | Human | Breast | IDC | 2.37e-02 | 2.18e-01 | 0.1636 |
| 9052 | GPRC5A | GSM4909311 | Human | Breast | IDC | 1.86e-12 | -1.35e-01 | 0.1534 |
| 9052 | GPRC5A | GSM4909312 | Human | Breast | IDC | 9.07e-08 | 3.78e-01 | 0.1552 |
| 9052 | GPRC5A | GSM4909313 | Human | Breast | IDC | 8.52e-06 | 5.09e-01 | 0.0391 |
| 9052 | GPRC5A | GSM4909317 | Human | Breast | IDC | 1.49e-03 | 3.99e-01 | 0.1355 |
| 9052 | GPRC5A | GSM4909319 | Human | Breast | IDC | 3.62e-14 | -2.20e-01 | 0.1563 |
| 9052 | GPRC5A | GSM4909321 | Human | Breast | IDC | 5.05e-09 | 3.57e-01 | 0.1559 |
| 9052 | GPRC5A | ctrl6 | Human | Breast | Precancer | 2.60e-32 | 1.18e+00 | -0.0061 |
| 9052 | GPRC5A | brca3 | Human | Breast | Precancer | 5.84e-04 | 3.43e-01 | -0.0263 |
| 9052 | GPRC5A | brca7 | Human | Breast | Precancer | 7.69e-03 | 8.28e-01 | -0.009 |
| 9052 | GPRC5A | brca10 | Human | Breast | Precancer | 6.70e-33 | 9.48e-01 | -0.0029 |
| 9052 | GPRC5A | M2 | Human | Breast | IDC | 9.03e-03 | -3.61e-01 | 0.21 |
| 9052 | GPRC5A | NCCBC11 | Human | Breast | DCIS | 5.79e-03 | -3.61e-01 | 0.1232 |
| 9052 | GPRC5A | NCCBC14 | Human | Breast | DCIS | 4.62e-06 | -8.15e-02 | 0.2021 |
| 9052 | GPRC5A | NCCBC3 | Human | Breast | DCIS | 1.71e-12 | -3.17e-01 | 0.1198 |
| 9052 | GPRC5A | NCCBC5 | Human | Breast | DCIS | 8.16e-05 | -1.87e-01 | 0.2046 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00336749 | Breast | Precancer | positive regulation of kinase activity | 42/1080 | 467/18723 | 2.94e-03 | 2.54e-02 | 42 |
| GO:00513489 | Breast | Precancer | negative regulation of transferase activity | 27/1080 | 268/18723 | 3.49e-03 | 2.90e-02 | 27 |
| GO:005134814 | Breast | IDC | negative regulation of transferase activity | 39/1434 | 268/18723 | 7.89e-05 | 1.56e-03 | 39 |
| GO:00459369 | Breast | IDC | negative regulation of phosphate metabolic process | 53/1434 | 441/18723 | 7.21e-04 | 8.79e-03 | 53 |
| GO:00105639 | Breast | IDC | negative regulation of phosphorus metabolic process | 53/1434 | 442/18723 | 7.60e-04 | 9.25e-03 | 53 |
| GO:00064699 | Breast | IDC | negative regulation of protein kinase activity | 27/1434 | 212/18723 | 6.30e-03 | 4.47e-02 | 27 |
| GO:005134824 | Breast | DCIS | negative regulation of transferase activity | 39/1390 | 268/18723 | 4.02e-05 | 8.60e-04 | 39 |
| GO:004593614 | Breast | DCIS | negative regulation of phosphate metabolic process | 53/1390 | 441/18723 | 3.48e-04 | 4.96e-03 | 53 |
| GO:001056314 | Breast | DCIS | negative regulation of phosphorus metabolic process | 53/1390 | 442/18723 | 3.68e-04 | 5.18e-03 | 53 |
| GO:000646913 | Breast | DCIS | negative regulation of protein kinase activity | 27/1390 | 212/18723 | 4.18e-03 | 3.30e-02 | 27 |
| GO:00423269 | Breast | DCIS | negative regulation of phosphorylation | 43/1390 | 385/18723 | 4.78e-03 | 3.62e-02 | 43 |
| GO:00019339 | Breast | DCIS | negative regulation of protein phosphorylation | 39/1390 | 342/18723 | 4.94e-03 | 3.71e-02 | 39 |
| GO:00336738 | Breast | DCIS | negative regulation of kinase activity | 29/1390 | 237/18723 | 5.44e-03 | 3.99e-02 | 29 |
| GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
| GO:00071738 | Cervix | CC | epidermal growth factor receptor signaling pathway | 36/2311 | 108/18723 | 1.04e-08 | 8.44e-07 | 36 |
| GO:00458608 | Cervix | CC | positive regulation of protein kinase activity | 85/2311 | 386/18723 | 5.61e-08 | 3.29e-06 | 85 |
| GO:00381278 | Cervix | CC | ERBB signaling pathway | 37/2311 | 121/18723 | 8.57e-08 | 4.88e-06 | 37 |
| GO:005134810 | Cervix | CC | negative regulation of transferase activity | 60/2311 | 268/18723 | 2.77e-06 | 8.02e-05 | 60 |
| GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
| GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GPRC5A | SNV | Missense_Mutation | rs745823691 | c.1007N>A | p.Ser336Tyr | p.S336Y | Q8NFJ5 | protein_coding | tolerated(0.44) | probably_damaging(0.997) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| GPRC5A | SNV | Missense_Mutation | novel | c.764T>G | p.Val255Gly | p.V255G | Q8NFJ5 | protein_coding | deleterious(0) | possibly_damaging(0.767) | TCGA-AO-A1KT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD |
| GPRC5A | SNV | Missense_Mutation | novel | c.514N>T | p.Arg172Cys | p.R172C | Q8NFJ5 | protein_coding | deleterious(0.01) | possibly_damaging(0.745) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| GPRC5A | SNV | Missense_Mutation | c.313T>G | p.Phe105Val | p.F105V | Q8NFJ5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| GPRC5A | SNV | Missense_Mutation | rs775011273 | c.88N>A | p.Val30Ile | p.V30I | Q8NFJ5 | protein_coding | tolerated(0.14) | benign(0.03) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
| GPRC5A | SNV | Missense_Mutation | rs775011273 | c.88N>A | p.Val30Ile | p.V30I | Q8NFJ5 | protein_coding | tolerated(0.14) | benign(0.03) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
| GPRC5A | SNV | Missense_Mutation | c.962C>T | p.Ser321Phe | p.S321F | Q8NFJ5 | protein_coding | deleterious(0.01) | benign(0.384) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| GPRC5A | SNV | Missense_Mutation | novel | c.250N>C | p.Ala84Pro | p.A84P | Q8NFJ5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A02W-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| GPRC5A | SNV | Missense_Mutation | c.643N>T | p.Leu215Phe | p.L215F | Q8NFJ5 | protein_coding | tolerated(0.2) | benign(0.027) | TCGA-NH-A6GB-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
| GPRC5A | SNV | Missense_Mutation | novel | c.752C>T | p.Ala251Val | p.A251V | Q8NFJ5 | protein_coding | tolerated(0.38) | benign(0.069) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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