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Gene: GPR82 |
Gene summary for GPR82 |
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Gene information | Species | Human | Gene symbol | GPR82 | Gene ID | 27197 |
Gene name | G protein-coupled receptor 82 | |
Gene Alias | GPR82 | |
Cytomap | Xp11.4 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q96P67 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27197 | GPR82 | HCC1 | Human | Liver | HCC | 4.10e-44 | 3.31e+00 | 0.5336 |
27197 | GPR82 | HCC2 | Human | Liver | HCC | 7.60e-64 | 4.13e+00 | 0.5341 |
27197 | GPR82 | HCC5 | Human | Liver | HCC | 5.30e-101 | 4.31e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPR82 | insertion | Frame_Shift_Ins | novel | c.811_812insT | p.Tyr273LeufsTer8 | p.Y273Lfs*8 | Q96P67 | protein_coding | TCGA-D8-A1JC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | ||
GPR82 | SNV | Missense_Mutation | rs368375953 | c.439C>T | p.Arg147Cys | p.R147C | Q96P67 | protein_coding | tolerated(0.12) | benign(0.111) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GPR82 | SNV | Missense_Mutation | c.325N>T | p.Ile109Phe | p.I109F | Q96P67 | protein_coding | deleterious(0.01) | possibly_damaging(0.53) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GPR82 | SNV | Missense_Mutation | c.436T>C | p.Phe146Leu | p.F146L | Q96P67 | protein_coding | tolerated(0.19) | probably_damaging(0.998) | TCGA-AH-6903-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fu | CR | |
GPR82 | deletion | Frame_Shift_Del | c.136delN | p.Thr48HisfsTer11 | p.T48Hfs*11 | Q96P67 | protein_coding | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
GPR82 | SNV | Missense_Mutation | novel | c.746N>T | p.Arg249Ile | p.R249I | Q96P67 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPR82 | SNV | Missense_Mutation | novel | c.801N>G | p.Ile267Met | p.I267M | Q96P67 | protein_coding | deleterious(0) | possibly_damaging(0.694) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPR82 | SNV | Missense_Mutation | novel | c.38N>C | p.Ile13Thr | p.I13T | Q96P67 | protein_coding | tolerated(0.22) | benign(0.08) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GPR82 | SNV | Missense_Mutation | novel | c.833N>T | p.Arg278Ile | p.R278I | Q96P67 | protein_coding | tolerated(0.18) | benign(0.062) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
GPR82 | SNV | Missense_Mutation | c.485N>G | p.Val162Gly | p.V162G | Q96P67 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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