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Gene: GPR35 |
Gene summary for GPR35 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GPR35 | Gene ID | 2859 |
| Gene name | G protein-coupled receptor 35 | |
| Gene Alias | GPR35 | |
| Cytomap | 2q37.3 | |
| Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | Q9HC97 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2859 | GPR35 | A015-C-203 | Human | Colorectum | FAP | 1.42e-06 | 2.84e-01 | -0.1294 |
| 2859 | GPR35 | A015-C-104 | Human | Colorectum | FAP | 6.02e-03 | 1.51e-01 | -0.1899 |
| 2859 | GPR35 | A015-C-202 | Human | Colorectum | FAP | 1.86e-03 | 3.45e-01 | -0.0849 |
| 2859 | GPR35 | A015-C-002 | Human | Colorectum | FAP | 5.20e-07 | 6.04e-01 | -0.0763 |
| 2859 | GPR35 | A014-C-008 | Human | Colorectum | FAP | 4.82e-03 | 3.60e-01 | -0.191 |
| 2859 | GPR35 | CRC-3-11773 | Human | Colorectum | CRC | 1.48e-06 | 4.28e-01 | 0.2564 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00510562 | Colorectum | FAP | regulation of small GTPase mediated signal transduction | 78/2622 | 302/18723 | 3.25e-08 | 2.85e-06 | 78 |
| GO:00072652 | Colorectum | FAP | Ras protein signal transduction | 80/2622 | 337/18723 | 9.61e-07 | 4.33e-05 | 80 |
| GO:00465781 | Colorectum | FAP | regulation of Ras protein signal transduction | 47/2622 | 189/18723 | 4.67e-05 | 9.60e-04 | 47 |
| GO:00228981 | Colorectum | FAP | regulation of transmembrane transporter activity | 62/2622 | 278/18723 | 1.09e-04 | 1.80e-03 | 62 |
| GO:00324121 | Colorectum | FAP | regulation of ion transmembrane transporter activity | 60/2622 | 267/18723 | 1.12e-04 | 1.84e-03 | 60 |
| GO:00324092 | Colorectum | FAP | regulation of transporter activity | 67/2622 | 310/18723 | 1.59e-04 | 2.43e-03 | 67 |
| GO:0010959 | Colorectum | FAP | regulation of metal ion transport | 83/2622 | 406/18723 | 2.06e-04 | 2.96e-03 | 83 |
| GO:0001508 | Colorectum | FAP | action potential | 34/2622 | 134/18723 | 3.30e-04 | 4.22e-03 | 34 |
| GO:00072661 | Colorectum | FAP | Rho protein signal transduction | 34/2622 | 137/18723 | 5.11e-04 | 5.82e-03 | 34 |
| GO:00510512 | Colorectum | FAP | negative regulation of transport | 91/2622 | 470/18723 | 7.09e-04 | 7.64e-03 | 91 |
| GO:0098900 | Colorectum | FAP | regulation of action potential | 16/2622 | 55/18723 | 2.78e-03 | 2.15e-02 | 16 |
| GO:1904062 | Colorectum | FAP | regulation of cation transmembrane transport | 69/2622 | 357/18723 | 3.06e-03 | 2.30e-02 | 69 |
| GO:0035023 | Colorectum | FAP | regulation of Rho protein signal transduction | 22/2622 | 86/18723 | 3.11e-03 | 2.33e-02 | 22 |
| GO:00510563 | Colorectum | CRC | regulation of small GTPase mediated signal transduction | 69/2078 | 302/18723 | 3.34e-09 | 9.08e-07 | 69 |
| GO:00072653 | Colorectum | CRC | Ras protein signal transduction | 70/2078 | 337/18723 | 1.49e-07 | 1.66e-05 | 70 |
| GO:00465782 | Colorectum | CRC | regulation of Ras protein signal transduction | 43/2078 | 189/18723 | 3.26e-06 | 1.47e-04 | 43 |
| GO:00228982 | Colorectum | CRC | regulation of transmembrane transporter activity | 56/2078 | 278/18723 | 6.75e-06 | 2.58e-04 | 56 |
| GO:00324122 | Colorectum | CRC | regulation of ion transmembrane transporter activity | 54/2078 | 267/18723 | 8.67e-06 | 3.09e-04 | 54 |
| GO:00015081 | Colorectum | CRC | action potential | 32/2078 | 134/18723 | 2.02e-05 | 5.90e-04 | 32 |
| GO:00324093 | Colorectum | CRC | regulation of transporter activity | 59/2078 | 310/18723 | 2.34e-05 | 6.65e-04 | 59 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GPR35 | SNV | Missense_Mutation | rs372449386 | c.127N>A | p.Asp43Asn | p.D43N | Q9HC97 | protein_coding | tolerated(0.56) | benign(0.006) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| GPR35 | SNV | Missense_Mutation | c.607T>A | p.Ser203Thr | p.S203T | Q9HC97 | protein_coding | tolerated(1) | benign(0.013) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| GPR35 | SNV | Missense_Mutation | c.287N>T | p.Ala96Val | p.A96V | Q9HC97 | protein_coding | tolerated(0.06) | probably_damaging(0.959) | TCGA-E2-A158-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | arimidex | SD | |
| GPR35 | SNV | Missense_Mutation | c.855N>G | p.Ile285Met | p.I285M | Q9HC97 | protein_coding | tolerated(0.08) | benign(0.07) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
| GPR35 | SNV | Missense_Mutation | c.606N>A | p.Asn202Lys | p.N202K | Q9HC97 | protein_coding | tolerated(0.89) | benign(0.005) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| GPR35 | SNV | Missense_Mutation | c.569N>A | p.Gly190Asp | p.G190D | Q9HC97 | protein_coding | tolerated(0.14) | probably_damaging(0.947) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
| GPR35 | SNV | Missense_Mutation | rs143712491 | c.499N>A | p.Val167Met | p.V167M | Q9HC97 | protein_coding | deleterious(0.02) | possibly_damaging(0.733) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
| GPR35 | SNV | Missense_Mutation | c.301N>A | p.Leu101Met | p.L101M | Q9HC97 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| GPR35 | SNV | Missense_Mutation | rs140850565 | c.743G>A | p.Arg248His | p.R248H | Q9HC97 | protein_coding | tolerated(0.51) | benign(0.062) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
| GPR35 | SNV | Missense_Mutation | rs144723282 | c.950N>T | p.Ala317Val | p.A317V | Q9HC97 | protein_coding | tolerated(0.1) | possibly_damaging(0.867) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 2859 | GPR35 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178101541 | FUROSEMIDE | |
| 2859 | GPR35 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650787 | ||
| 2859 | GPR35 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651497 | ||
| 2859 | GPR35 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 354702215 | ||
| 2859 | GPR35 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 354702216 | LODOXAMIDE | |
| 2859 | GPR35 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | TOLCAPONE | TOLCAPONE | ||
| 2859 | GPR35 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | RO-410960 | CHEMBL1256291 | ||
| 2859 | GPR35 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178101539 | BUMETANIDE | |
| 2859 | GPR35 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | DNDI1417434 | CHEMBL394883 | ||
| 2859 | GPR35 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | CID 27456 | CHEMBL1708510 | 21950657 |
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