![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GPR161 |
Gene summary for GPR161 |
![]() |
Gene information | Species | Human | Gene symbol | GPR161 | Gene ID | 23432 |
Gene name | G protein-coupled receptor 161 | |
Gene Alias | RE2 | |
Cytomap | 1q24.2 | |
Gene Type | protein-coding | GO ID | GO:0003002 | UniProtAcc | Q8N6U8 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23432 | GPR161 | LZE2T | Human | Esophagus | ESCC | 3.65e-05 | 6.68e-01 | 0.082 |
23432 | GPR161 | LZE7T | Human | Esophagus | ESCC | 4.57e-04 | 4.64e-01 | 0.0667 |
23432 | GPR161 | P2T-E | Human | Esophagus | ESCC | 2.35e-19 | 4.24e-01 | 0.1177 |
23432 | GPR161 | P4T-E | Human | Esophagus | ESCC | 1.63e-16 | 4.59e-01 | 0.1323 |
23432 | GPR161 | P5T-E | Human | Esophagus | ESCC | 1.33e-03 | 3.57e-02 | 0.1327 |
23432 | GPR161 | P8T-E | Human | Esophagus | ESCC | 2.20e-05 | 6.73e-02 | 0.0889 |
23432 | GPR161 | P9T-E | Human | Esophagus | ESCC | 7.30e-10 | 2.99e-01 | 0.1131 |
23432 | GPR161 | P10T-E | Human | Esophagus | ESCC | 9.41e-44 | 8.59e-01 | 0.116 |
23432 | GPR161 | P12T-E | Human | Esophagus | ESCC | 2.84e-12 | 2.10e-01 | 0.1122 |
23432 | GPR161 | P15T-E | Human | Esophagus | ESCC | 5.39e-22 | 7.48e-01 | 0.1149 |
23432 | GPR161 | P16T-E | Human | Esophagus | ESCC | 1.95e-12 | 2.82e-01 | 0.1153 |
23432 | GPR161 | P20T-E | Human | Esophagus | ESCC | 1.18e-08 | 1.56e-01 | 0.1124 |
23432 | GPR161 | P21T-E | Human | Esophagus | ESCC | 2.43e-11 | 1.68e-01 | 0.1617 |
23432 | GPR161 | P22T-E | Human | Esophagus | ESCC | 1.67e-27 | 4.90e-01 | 0.1236 |
23432 | GPR161 | P24T-E | Human | Esophagus | ESCC | 1.69e-06 | 1.05e-01 | 0.1287 |
23432 | GPR161 | P26T-E | Human | Esophagus | ESCC | 3.12e-02 | 1.11e-01 | 0.1276 |
23432 | GPR161 | P27T-E | Human | Esophagus | ESCC | 5.36e-08 | 1.78e-01 | 0.1055 |
23432 | GPR161 | P28T-E | Human | Esophagus | ESCC | 9.09e-07 | 2.44e-01 | 0.1149 |
23432 | GPR161 | P30T-E | Human | Esophagus | ESCC | 9.76e-09 | 5.31e-01 | 0.137 |
23432 | GPR161 | P31T-E | Human | Esophagus | ESCC | 7.11e-22 | 4.84e-01 | 0.1251 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00219159 | Esophagus | ESCC | neural tube development | 101/8552 | 152/18723 | 1.78e-07 | 2.79e-06 | 101 |
GO:00219154 | Liver | HCC | neural tube development | 82/7958 | 152/18723 | 2.83e-03 | 1.33e-02 | 82 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPR161 | SNV | Missense_Mutation | c.664C>G | p.Leu222Val | p.L222V | Q8N6U8 | protein_coding | tolerated(0.7) | benign(0) | TCGA-A2-A0EP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR | |
GPR161 | SNV | Missense_Mutation | c.47N>T | p.Arg16Leu | p.R16L | Q8N6U8 | protein_coding | tolerated_low_confidence(0.44) | benign(0) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
GPR161 | SNV | Missense_Mutation | c.331N>G | p.Arg111Gly | p.R111G | Q8N6U8 | protein_coding | tolerated(0.36) | benign(0.022) | TCGA-A8-A07L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | CR | ||
GPR161 | SNV | Missense_Mutation | rs148848526 | c.1565N>A | p.Arg522His | p.R522H | Q8N6U8 | protein_coding | deleterious_low_confidence(0.02) | benign(0.003) | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPR161 | SNV | Missense_Mutation | c.811N>G | p.Ser271Gly | p.S271G | Q8N6U8 | protein_coding | tolerated(0.07) | probably_damaging(0.957) | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
GPR161 | SNV | Missense_Mutation | novel | c.1382N>G | p.Lys461Arg | p.K461R | Q8N6U8 | protein_coding | tolerated_low_confidence(0.26) | benign(0.003) | TCGA-B6-A40C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | cyclophosphamide | SD |
GPR161 | SNV | Missense_Mutation | c.881T>C | p.Val294Ala | p.V294A | Q8N6U8 | protein_coding | deleterious(0) | possibly_damaging(0.63) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPR161 | SNV | Missense_Mutation | rs868239535 | c.290N>T | p.Ser97Phe | p.S97F | Q8N6U8 | protein_coding | deleterious(0) | possibly_damaging(0.839) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPR161 | insertion | Frame_Shift_Ins | novel | c.1311_1312insAAAGCAAAAAAAAAACCAAAAAAAAATC | p.Pro438LysfsTer26 | p.P438Kfs*26 | Q8N6U8 | protein_coding | TCGA-AO-A0JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophospamide | SD | ||
GPR161 | insertion | Frame_Shift_Ins | novel | c.1309_1310insAT | p.Pro437HisfsTer16 | p.P437Hfs*16 | Q8N6U8 | protein_coding | TCGA-AO-A0JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophospamide | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |