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Gene: GPR137C |
Gene summary for GPR137C |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GPR137C | Gene ID | 283554 |
| Gene name | G protein-coupled receptor 137C | |
| Gene Alias | TM7SF1L2 | |
| Cytomap | 14q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | B3KW22 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 283554 | GPR137C | RNA-P17T-P17T-2 | Human | Lung | IAC | 5.30e-08 | 7.63e-01 | 0.3371 |
| 283554 | GPR137C | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.13e-06 | 8.13e-01 | 0.343 |
| 283554 | GPR137C | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.48e-03 | 5.15e-01 | 0.3385 |
| 283554 | GPR137C | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.55e-04 | 5.24e-01 | 0.3329 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GPR137C | SNV | Missense_Mutation | novel | c.749G>A | p.Gly250Asp | p.G250D | Q8N3F9 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-A2-A3XV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| GPR137C | SNV | Missense_Mutation | c.773N>G | p.Ser258Cys | p.S258C | Q8N3F9 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
| GPR137C | SNV | Missense_Mutation | rs752405401 | c.571G>A | p.Asp191Asn | p.D191N | Q8N3F9 | protein_coding | tolerated(0.3) | benign(0.068) | TCGA-DG-A2KL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
| GPR137C | SNV | Missense_Mutation | rs766673125 | c.326N>T | p.Ser109Phe | p.S109F | Q8N3F9 | protein_coding | deleterious(0.03) | benign(0.413) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
| GPR137C | SNV | Missense_Mutation | novel | c.938T>A | p.Val313Glu | p.V313E | Q8N3F9 | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| GPR137C | SNV | Missense_Mutation | novel | c.840T>G | p.Asn280Lys | p.N280K | Q8N3F9 | protein_coding | deleterious(0.01) | possibly_damaging(0.88) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| GPR137C | SNV | Missense_Mutation | c.764N>A | p.Leu255His | p.L255H | Q8N3F9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
| GPR137C | SNV | Missense_Mutation | rs761857890 | c.1124N>T | p.Ser375Leu | p.S375L | Q8N3F9 | protein_coding | tolerated(0.13) | benign(0.118) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| GPR137C | SNV | Missense_Mutation | c.836N>G | p.Phe279Cys | p.F279C | Q8N3F9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| GPR137C | SNV | Missense_Mutation | c.991N>G | p.Leu331Val | p.L331V | Q8N3F9 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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