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Gene: GPR132 |
Gene summary for GPR132 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GPR132 | Gene ID | 29933 |
| Gene name | G protein-coupled receptor 132 | |
| Gene Alias | G2A | |
| Cytomap | 14q32.33 | |
| Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q9UNW8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 29933 | GPR132 | RNA-P17T-P17T-2 | Human | Lung | IAC | 5.30e-08 | 6.89e-01 | 0.3371 |
| 29933 | GPR132 | RNA-P17T-P17T-4 | Human | Lung | IAC | 4.28e-05 | 5.95e-01 | 0.343 |
| 29933 | GPR132 | RNA-P17T-P17T-6 | Human | Lung | IAC | 5.52e-10 | 7.92e-01 | 0.3385 |
| 29933 | GPR132 | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.41e-10 | 7.46e-01 | 0.3329 |
| 29933 | GPR132 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.32e-03 | 2.03e-01 | -0.013 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00447723 | Lung | IAC | mitotic cell cycle phase transition | 85/2061 | 424/18723 | 2.69e-08 | 3.20e-06 | 85 |
| GO:00000823 | Lung | IAC | G1/S transition of mitotic cell cycle | 46/2061 | 214/18723 | 6.13e-06 | 2.29e-04 | 46 |
| GO:00448433 | Lung | IAC | cell cycle G1/S phase transition | 49/2061 | 241/18723 | 1.54e-05 | 4.49e-04 | 49 |
| GO:19019872 | Lung | IAC | regulation of cell cycle phase transition | 69/2061 | 390/18723 | 4.55e-05 | 1.06e-03 | 69 |
| GO:00073464 | Lung | IAC | regulation of mitotic cell cycle | 78/2061 | 457/18723 | 5.37e-05 | 1.21e-03 | 78 |
| GO:00457861 | Lung | IAC | negative regulation of cell cycle | 67/2061 | 385/18723 | 9.74e-05 | 1.93e-03 | 67 |
| GO:00459301 | Lung | IAC | negative regulation of mitotic cell cycle | 45/2061 | 235/18723 | 1.49e-04 | 2.73e-03 | 45 |
| GO:19019881 | Lung | IAC | negative regulation of cell cycle phase transition | 47/2061 | 249/18723 | 1.53e-04 | 2.80e-03 | 47 |
| GO:00109481 | Lung | IAC | negative regulation of cell cycle process | 53/2061 | 294/18723 | 2.05e-04 | 3.58e-03 | 53 |
| GO:19019902 | Lung | IAC | regulation of mitotic cell cycle phase transition | 53/2061 | 299/18723 | 3.14e-04 | 4.98e-03 | 53 |
| GO:00448391 | Lung | IAC | cell cycle G2/M phase transition | 29/2061 | 148/18723 | 1.44e-03 | 1.55e-02 | 29 |
| GO:00000861 | Lung | IAC | G2/M transition of mitotic cell cycle | 27/2061 | 137/18723 | 1.88e-03 | 1.92e-02 | 27 |
| GO:19019911 | Lung | IAC | negative regulation of mitotic cell cycle phase transition | 33/2061 | 179/18723 | 2.05e-03 | 2.05e-02 | 33 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GPR132 | SNV | Missense_Mutation | novel | c.853N>G | p.Arg285Gly | p.R285G | Q9UNW8 | protein_coding | tolerated(0.17) | benign(0.129) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| GPR132 | SNV | Missense_Mutation | c.767N>T | p.Ala256Val | p.A256V | Q9UNW8 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AR-A24Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| GPR132 | SNV | Missense_Mutation | rs776897887 | c.419N>A | p.Arg140His | p.R140H | Q9UNW8 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| GPR132 | SNV | Missense_Mutation | rs778976347 | c.40N>A | p.Ala14Thr | p.A14T | Q9UNW8 | protein_coding | tolerated_low_confidence(0.38) | benign(0.001) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| GPR132 | SNV | Missense_Mutation | c.455G>A | p.Gly152Asp | p.G152D | Q9UNW8 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| GPR132 | SNV | Missense_Mutation | c.908C>T | p.Ala303Val | p.A303V | Q9UNW8 | protein_coding | tolerated(0.17) | benign(0.402) | TCGA-A6-A566-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | PD | |
| GPR132 | SNV | Missense_Mutation | rs754386954 | c.508N>A | p.Val170Ile | p.V170I | Q9UNW8 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-AA-3685-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| GPR132 | SNV | Missense_Mutation | rs200040782 | c.517G>A | p.Val173Ile | p.V173I | Q9UNW8 | protein_coding | tolerated(0.85) | benign(0.173) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| GPR132 | SNV | Missense_Mutation | c.832N>A | p.Ala278Thr | p.A278T | Q9UNW8 | protein_coding | tolerated(0.43) | benign(0.005) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
| GPR132 | SNV | Missense_Mutation | rs61737889 | c.308N>A | p.Arg103His | p.R103H | Q9UNW8 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 29933 | GPR132 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178102204 |
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