Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: GPR107

Gene summary for GPR107

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

GPR107

Gene ID

57720

Gene nameG protein-coupled receptor 107
Gene AliasGCDRP
Cytomap9q34.11
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

Q5VW38


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
57720GPR107CCI_1HumanCervixCC2.06e-024.10e-010.528
57720GPR107CCI_2HumanCervixCC4.08e-116.54e-010.5249
57720GPR107CCI_3HumanCervixCC4.93e-136.26e-010.516
57720GPR107HTA11_347_2000001011HumanColorectumAD2.19e-115.02e-01-0.1954
57720GPR107HTA11_99999965104_69814HumanColorectumMSS3.48e-075.99e-010.281
57720GPR107A015-C-203HumanColorectumFAP3.26e-16-2.88e-01-0.1294
57720GPR107A015-C-204HumanColorectumFAP3.53e-03-2.46e-01-0.0228
57720GPR107A002-C-201HumanColorectumFAP2.68e-04-1.88e-010.0324
57720GPR107A002-C-203HumanColorectumFAP5.32e-03-1.01e-010.2786
57720GPR107A001-C-119HumanColorectumFAP4.70e-02-2.86e-01-0.1557
57720GPR107A001-C-108HumanColorectumFAP2.19e-11-2.01e-01-0.0272
57720GPR107A002-C-205HumanColorectumFAP3.31e-10-1.70e-01-0.1236
57720GPR107A015-C-006HumanColorectumFAP5.29e-07-2.48e-01-0.0994
57720GPR107A015-C-106HumanColorectumFAP5.02e-06-2.02e-01-0.0511
57720GPR107A002-C-114HumanColorectumFAP1.19e-08-3.11e-01-0.1561
57720GPR107A015-C-104HumanColorectumFAP8.48e-20-3.34e-01-0.1899
57720GPR107A001-C-014HumanColorectumFAP4.06e-07-1.48e-010.0135
57720GPR107A002-C-016HumanColorectumFAP1.95e-13-2.21e-010.0521
57720GPR107A015-C-002HumanColorectumFAP1.61e-05-3.21e-01-0.0763
57720GPR107A001-C-203HumanColorectumFAP4.17e-05-9.93e-02-0.0481
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00068987CervixCCreceptor-mediated endocytosis53/2311244/187232.52e-054.29e-0453
GO:00725836CervixCCclathrin-dependent endocytosis16/231147/187239.56e-051.25e-0316
GO:0072583ColorectumADclathrin-dependent endocytosis24/391847/187234.60e-061.22e-0424
GO:0006898ColorectumADreceptor-mediated endocytosis76/3918244/187231.07e-041.59e-0376
GO:00725831ColorectumMSSclathrin-dependent endocytosis22/346747/187238.74e-062.16e-0422
GO:00068981ColorectumMSSreceptor-mediated endocytosis69/3467244/187231.18e-041.82e-0369
GO:00725832ColorectumFAPclathrin-dependent endocytosis21/262247/187233.45e-071.87e-0521
GO:00068982ColorectumFAPreceptor-mediated endocytosis62/2622244/187231.47e-066.39e-0562
GO:00725833ColorectumCRCclathrin-dependent endocytosis18/207847/187231.16e-066.75e-0518
GO:00068983ColorectumCRCreceptor-mediated endocytosis50/2078244/187231.27e-054.08e-0450
GO:000689818EsophagusESCCreceptor-mediated endocytosis142/8552244/187235.22e-054.05e-04142
GO:007258314EsophagusESCCclathrin-dependent endocytosis34/855247/187231.91e-041.21e-0334
GO:000689821LiverHCCreceptor-mediated endocytosis134/7958244/187235.73e-055.31e-04134
GO:007258311LiverHCCclathrin-dependent endocytosis31/795847/187239.90e-045.71e-0331
GO:000689810Oral cavityOSCCreceptor-mediated endocytosis125/7305244/187236.56e-055.32e-04125
GO:00725838Oral cavityOSCCclathrin-dependent endocytosis30/730547/187234.96e-042.92e-0330
GO:007258321Oral cavityEOLPclathrin-dependent endocytosis19/221847/187236.00e-071.56e-0519
GO:000689825Oral cavityEOLPreceptor-mediated endocytosis55/2218244/187231.64e-063.82e-0555
GO:0006898110ThyroidPTCreceptor-mediated endocytosis112/5968244/187232.87e-063.74e-05112
GO:007258310ThyroidPTCclathrin-dependent endocytosis30/596847/187236.62e-067.83e-0530
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
GPR107SNVMissense_Mutationc.1681N>Cp.Glu561Glnp.E561QQ5VW38protein_codingdeleterious(0)benign(0.354)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
GPR107SNVMissense_Mutationc.1576N>Ap.Leu526Ilep.L526IQ5VW38protein_codingdeleterious(0.01)benign(0.437)TCGA-AO-A0J5-01Breastbreast invasive carcinomaFemale<65III/IVOther, specify in notesBisphosphonatezoledronicPD
GPR107SNVMissense_Mutationrs759860772c.1103N>Tp.Lys368Metp.K368MQ5VW38protein_codingdeleterious(0)probably_damaging(0.998)TCGA-BH-A0DK-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
GPR107SNVMissense_Mutationrs368664209c.1547A>Gp.Lys516Argp.K516RQ5VW38protein_codingtolerated(0.23)benign(0.286)TCGA-HN-A2NL-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
GPR107insertionFrame_Shift_Insnovelc.219_220insAATTTGAATCCATTGAATACTTCCTTCTGCAGAAAp.Leu74AsnfsTer15p.L74Nfs*15Q5VW38protein_codingTCGA-A7-A0CJ-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
GPR107insertionFrame_Shift_Insnovelc.245_246insTAGTGCAGTGTGGTGTAGTTCTGTGp.Lys82AsnfsTer16p.K82Nfs*16Q5VW38protein_codingTCGA-BH-A0HK-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
GPR107SNVMissense_Mutationnovelc.1609N>Cp.Val537Leup.V537LQ5VW38protein_codingdeleterious(0.01)possibly_damaging(0.677)TCGA-EA-A3HU-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
GPR107SNVMissense_Mutationc.1729N>Ap.Glu577Lysp.E577KQ5VW38protein_codingdeleterious(0)probably_damaging(0.996)TCGA-IR-A3LH-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
GPR107SNVMissense_Mutationrs200754726c.854G>Ap.Arg285Glnp.R285QQ5VW38protein_codingtolerated(0.34)possibly_damaging(0.732)TCGA-UC-A7PG-06Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinPD
GPR107deletionFrame_Shift_Delnovelc.1631delNp.Tyr544LeufsTer27p.Y544Lfs*27Q5VW38protein_codingTCGA-MA-AA3X-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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