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Gene: GPBP1L1 |
Gene summary for GPBP1L1 |
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Gene information | Species | Human | Gene symbol | GPBP1L1 | Gene ID | 60313 |
Gene name | GC-rich promoter binding protein 1 like 1 | |
Gene Alias | SP192 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9HC44 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60313 | GPBP1L1 | CCI_1 | Human | Cervix | CC | 3.73e-02 | 5.37e-01 | 0.528 |
60313 | GPBP1L1 | CCI_2 | Human | Cervix | CC | 8.26e-07 | 9.61e-01 | 0.5249 |
60313 | GPBP1L1 | CCI_3 | Human | Cervix | CC | 3.95e-11 | 9.21e-01 | 0.516 |
60313 | GPBP1L1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.44e-23 | -5.67e-01 | 0.0155 |
60313 | GPBP1L1 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.02e-13 | 6.82e-01 | -0.1954 |
60313 | GPBP1L1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.29e-03 | -5.27e-01 | 0.2585 |
60313 | GPBP1L1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.22e-24 | -6.24e-01 | 0.3005 |
60313 | GPBP1L1 | F007 | Human | Colorectum | FAP | 3.23e-06 | -3.38e-01 | 0.1176 |
60313 | GPBP1L1 | A001-C-207 | Human | Colorectum | FAP | 7.79e-07 | -3.80e-01 | 0.1278 |
60313 | GPBP1L1 | A015-C-203 | Human | Colorectum | FAP | 1.65e-43 | -5.29e-01 | -0.1294 |
60313 | GPBP1L1 | A015-C-204 | Human | Colorectum | FAP | 4.86e-14 | -4.35e-01 | -0.0228 |
60313 | GPBP1L1 | A014-C-040 | Human | Colorectum | FAP | 1.60e-11 | -7.12e-01 | -0.1184 |
60313 | GPBP1L1 | A002-C-201 | Human | Colorectum | FAP | 6.11e-22 | -5.15e-01 | 0.0324 |
60313 | GPBP1L1 | A002-C-203 | Human | Colorectum | FAP | 3.15e-08 | -2.92e-01 | 0.2786 |
60313 | GPBP1L1 | A001-C-119 | Human | Colorectum | FAP | 1.50e-12 | -4.39e-01 | -0.1557 |
60313 | GPBP1L1 | A001-C-108 | Human | Colorectum | FAP | 1.59e-23 | -3.53e-01 | -0.0272 |
60313 | GPBP1L1 | A002-C-205 | Human | Colorectum | FAP | 1.89e-32 | -4.81e-01 | -0.1236 |
60313 | GPBP1L1 | A001-C-104 | Human | Colorectum | FAP | 1.55e-09 | -3.72e-01 | 0.0184 |
60313 | GPBP1L1 | A015-C-005 | Human | Colorectum | FAP | 6.52e-07 | -2.42e-01 | -0.0336 |
60313 | GPBP1L1 | A015-C-006 | Human | Colorectum | FAP | 3.44e-27 | -6.32e-01 | -0.0994 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPBP1L1 | SNV | Missense_Mutation | c.542G>C | p.Gly181Ala | p.G181A | Q9HC44 | protein_coding | deleterious(0.01) | possibly_damaging(0.861) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
GPBP1L1 | SNV | Missense_Mutation | novel | c.1215G>T | p.Glu405Asp | p.E405D | Q9HC44 | protein_coding | tolerated(0.22) | probably_damaging(0.913) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPBP1L1 | SNV | Missense_Mutation | rs780962835 | c.700G>A | p.Val234Ile | p.V234I | Q9HC44 | protein_coding | tolerated(0.09) | probably_damaging(0.987) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GPBP1L1 | SNV | Missense_Mutation | c.1165N>G | p.His389Asp | p.H389D | Q9HC44 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GPBP1L1 | SNV | Missense_Mutation | rs768034229 | c.79N>A | p.Glu27Lys | p.E27K | Q9HC44 | protein_coding | tolerated(0.09) | benign(0.01) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPBP1L1 | SNV | Missense_Mutation | c.1213G>A | p.Glu405Lys | p.E405K | Q9HC44 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-CM-6680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GPBP1L1 | SNV | Missense_Mutation | c.71N>T | p.Ala24Val | p.A24V | Q9HC44 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GPBP1L1 | SNV | Missense_Mutation | c.131G>A | p.Arg44His | p.R44H | Q9HC44 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-AG-A01N-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | SD | |
GPBP1L1 | SNV | Missense_Mutation | c.131G>A | p.Arg44His | p.R44H | Q9HC44 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GPBP1L1 | insertion | Frame_Shift_Ins | novel | c.162_163insT | p.Asn55Ter | p.N55* | Q9HC44 | protein_coding | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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