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Gene: GPBP1 |
Gene summary for GPBP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GPBP1 | Gene ID | 65056 |
Gene name | GC-rich promoter binding protein 1 | |
Gene Alias | GPBP | |
Cytomap | 5q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q86WP2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65056 | GPBP1 | GSM4909280 | Human | Breast | Precancer | 1.84e-04 | 1.70e-01 | 0.0305 |
65056 | GPBP1 | GSM4909282 | Human | Breast | IDC | 1.16e-07 | -4.39e-01 | -0.0288 |
65056 | GPBP1 | GSM4909286 | Human | Breast | IDC | 1.57e-12 | -3.77e-01 | 0.1081 |
65056 | GPBP1 | GSM4909287 | Human | Breast | IDC | 6.65e-04 | -3.12e-01 | 0.2057 |
65056 | GPBP1 | GSM4909290 | Human | Breast | IDC | 6.03e-09 | -4.56e-01 | 0.2096 |
65056 | GPBP1 | GSM4909291 | Human | Breast | IDC | 3.74e-05 | -3.95e-01 | 0.1753 |
65056 | GPBP1 | GSM4909292 | Human | Breast | IDC | 3.02e-02 | -6.05e-01 | 0.1236 |
65056 | GPBP1 | GSM4909294 | Human | Breast | IDC | 2.52e-09 | -3.76e-01 | 0.2022 |
65056 | GPBP1 | GSM4909296 | Human | Breast | IDC | 1.61e-26 | -4.99e-01 | 0.1524 |
65056 | GPBP1 | GSM4909297 | Human | Breast | IDC | 4.32e-28 | -3.91e-01 | 0.1517 |
65056 | GPBP1 | GSM4909301 | Human | Breast | IDC | 2.09e-11 | -4.12e-01 | 0.1577 |
65056 | GPBP1 | GSM4909302 | Human | Breast | IDC | 9.38e-04 | -2.54e-01 | 0.1545 |
65056 | GPBP1 | GSM4909304 | Human | Breast | IDC | 3.48e-07 | -3.66e-01 | 0.1636 |
65056 | GPBP1 | GSM4909306 | Human | Breast | IDC | 2.66e-08 | -3.52e-01 | 0.1564 |
65056 | GPBP1 | GSM4909307 | Human | Breast | IDC | 1.13e-04 | -3.21e-01 | 0.1569 |
65056 | GPBP1 | GSM4909309 | Human | Breast | IDC | 6.91e-09 | -3.92e-01 | 0.0483 |
65056 | GPBP1 | GSM4909311 | Human | Breast | IDC | 1.62e-45 | -6.88e-01 | 0.1534 |
65056 | GPBP1 | GSM4909312 | Human | Breast | IDC | 2.22e-24 | -5.19e-01 | 0.1552 |
65056 | GPBP1 | GSM4909313 | Human | Breast | IDC | 1.30e-07 | -2.73e-01 | 0.0391 |
65056 | GPBP1 | GSM4909315 | Human | Breast | IDC | 2.49e-04 | -3.40e-01 | 0.21 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPBP1 | SNV | Missense_Mutation | c.640N>G | p.Leu214Val | p.L214V | protein_coding | tolerated(0.52) | benign(0.012) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
GPBP1 | SNV | Missense_Mutation | novel | c.890C>T | p.Pro297Leu | p.P297L | protein_coding | deleterious(0.02) | benign(0.022) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GPBP1 | SNV | Missense_Mutation | c.1288N>C | p.Asp430His | p.D430H | protein_coding | deleterious(0.02) | probably_damaging(0.919) | TCGA-BI-A0VR-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | ||
GPBP1 | SNV | Missense_Mutation | c.433N>C | p.Glu145Gln | p.E145Q | protein_coding | tolerated(0.24) | probably_damaging(0.995) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
GPBP1 | SNV | Missense_Mutation | c.661N>C | p.Asn221His | p.N221H | protein_coding | tolerated(0.05) | possibly_damaging(0.569) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
GPBP1 | SNV | Missense_Mutation | c.778N>T | p.His260Tyr | p.H260Y | protein_coding | tolerated(0.9) | benign(0.432) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
GPBP1 | SNV | Missense_Mutation | c.1280N>C | p.Leu427Ser | p.L427S | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
GPBP1 | SNV | Missense_Mutation | rs761214960 | c.220N>T | p.Arg74Cys | p.R74C | protein_coding | deleterious(0.04) | benign(0.031) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GPBP1 | SNV | Missense_Mutation | rs372116041 | c.493N>G | p.Thr165Ala | p.T165A | protein_coding | tolerated_low_confidence(0.44) | probably_damaging(0.953) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GPBP1 | SNV | Missense_Mutation | c.361G>A | p.Gly121Arg | p.G121R | protein_coding | tolerated(0.89) | benign(0.023) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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