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Gene: GPA33 |
Gene summary for GPA33 |
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Gene information | Species | Human | Gene symbol | GPA33 | Gene ID | 10223 |
Gene name | glycoprotein A33 | |
Gene Alias | A33 | |
Cytomap | 1q24.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q99795 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10223 | GPA33 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.19e-28 | 1.83e+00 | -0.1808 |
10223 | GPA33 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.14e-22 | 1.45e+00 | -0.0811 |
10223 | GPA33 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.73e-16 | 9.71e-01 | -0.1088 |
10223 | GPA33 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.18e-64 | 1.88e+00 | -0.1954 |
10223 | GPA33 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.04e-18 | 2.55e+00 | -0.2602 |
10223 | GPA33 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.39e-17 | 1.95e+00 | -0.2196 |
10223 | GPA33 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.04e-24 | 1.49e+00 | -0.1207 |
10223 | GPA33 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.01e-24 | 1.37e+00 | -0.1526 |
10223 | GPA33 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.02e-42 | 1.78e+00 | -0.1464 |
10223 | GPA33 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.22e-24 | 9.96e-01 | -0.1001 |
10223 | GPA33 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.20e-24 | 1.45e+00 | -0.059 |
10223 | GPA33 | HTA11_2992_2000001011 | Human | Colorectum | SER | 9.35e-12 | 1.73e+00 | -0.1706 |
10223 | GPA33 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.64e-24 | 2.14e+00 | -0.2061 |
10223 | GPA33 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.61e-10 | 1.58e+00 | -0.1462 |
10223 | GPA33 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.68e-07 | 9.02e-01 | -0.0842 |
10223 | GPA33 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.06e-04 | 8.83e-01 | -0.00410000000000005 |
10223 | GPA33 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.25e-02 | 5.42e-01 | -0.0179 |
10223 | GPA33 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.66e-05 | 8.43e-01 | 0.0446 |
10223 | GPA33 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.73e-06 | 7.87e-01 | 0.0528 |
10223 | GPA33 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.25e-03 | 4.24e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPA33 | SNV | Missense_Mutation | rs370661795 | c.793N>A | p.Asp265Asn | p.D265N | Q99795 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-A2-A0YL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
GPA33 | SNV | Missense_Mutation | c.663N>G | p.Phe221Leu | p.F221L | Q99795 | protein_coding | tolerated(0.09) | benign(0.005) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
GPA33 | deletion | Frame_Shift_Del | novel | c.559delC | p.Leu187TrpfsTer12 | p.L187Wfs*12 | Q99795 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GPA33 | SNV | Missense_Mutation | novel | c.699N>A | p.Met233Ile | p.M233I | Q99795 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GPA33 | SNV | Missense_Mutation | novel | c.500G>A | p.Gly167Asp | p.G167D | Q99795 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GPA33 | SNV | Missense_Mutation | c.781N>C | p.Cys261Arg | p.C261R | Q99795 | protein_coding | deleterious(0) | benign(0.387) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPA33 | SNV | Missense_Mutation | c.767N>C | p.Ile256Thr | p.I256T | Q99795 | protein_coding | deleterious(0.04) | benign(0.037) | TCGA-A5-A0GA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |
GPA33 | SNV | Missense_Mutation | novel | c.634A>G | p.Thr212Ala | p.T212A | Q99795 | protein_coding | deleterious(0.05) | benign(0.187) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GPA33 | SNV | Missense_Mutation | rs540996886 | c.674N>T | p.Thr225Met | p.T225M | Q99795 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
GPA33 | SNV | Missense_Mutation | novel | c.213N>G | p.Ile71Met | p.I71M | Q99795 | protein_coding | deleterious(0.02) | possibly_damaging(0.715) | TCGA-AJ-A3QS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10223 | GPA33 | DRUGGABLE GENOME | MGD007 | MGD-007 | ||
10223 | GPA33 | DRUGGABLE GENOME | KRN-330 | KRN-330 | ||
10223 | GPA33 | DRUGGABLE GENOME | HuA33 | HUA33 | ||
10223 | GPA33 | DRUGGABLE GENOME | Radiolabelled-huA33 | |||
10223 | GPA33 | DRUGGABLE GENOME | KRN-330 | KRN-330 |
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