Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: GPA33

Gene summary for GPA33

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

GPA33

Gene ID

10223

Gene nameglycoprotein A33
Gene AliasA33
Cytomap1q24.1
Gene Typeprotein-coding
GO ID

GO:0005575

UniProtAcc

Q99795


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10223GPA33HTA11_2487_2000001011HumanColorectumSER4.19e-281.83e+00-0.1808
10223GPA33HTA11_1938_2000001011HumanColorectumAD3.14e-221.45e+00-0.0811
10223GPA33HTA11_78_2000001011HumanColorectumAD6.73e-169.71e-01-0.1088
10223GPA33HTA11_347_2000001011HumanColorectumAD3.18e-641.88e+00-0.1954
10223GPA33HTA11_411_2000001011HumanColorectumSER4.04e-182.55e+00-0.2602
10223GPA33HTA11_2112_2000001011HumanColorectumSER1.39e-171.95e+00-0.2196
10223GPA33HTA11_3361_2000001011HumanColorectumAD6.04e-241.49e+00-0.1207
10223GPA33HTA11_83_2000001011HumanColorectumSER3.01e-241.37e+00-0.1526
10223GPA33HTA11_696_2000001011HumanColorectumAD4.02e-421.78e+00-0.1464
10223GPA33HTA11_866_2000001011HumanColorectumAD2.22e-249.96e-01-0.1001
10223GPA33HTA11_1391_2000001011HumanColorectumAD4.20e-241.45e+00-0.059
10223GPA33HTA11_2992_2000001011HumanColorectumSER9.35e-121.73e+00-0.1706
10223GPA33HTA11_5212_2000001011HumanColorectumAD8.64e-242.14e+00-0.2061
10223GPA33HTA11_5216_2000001011HumanColorectumSER6.61e-101.58e+00-0.1462
10223GPA33HTA11_546_2000001011HumanColorectumAD2.68e-079.02e-01-0.0842
10223GPA33HTA11_9341_2000001011HumanColorectumSER3.06e-048.83e-01-0.00410000000000005
10223GPA33HTA11_7862_2000001011HumanColorectumAD2.25e-025.42e-01-0.0179
10223GPA33HTA11_4255_2000001011HumanColorectumSER3.66e-058.43e-010.0446
10223GPA33HTA11_8622_2000001021HumanColorectumSER4.73e-067.87e-010.0528
10223GPA33HTA11_7696_3000711011HumanColorectumAD4.25e-034.24e-010.0674
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
GPA33SNVMissense_Mutationrs370661795c.793N>Ap.Asp265Asnp.D265NQ99795protein_codingtolerated(0.15)benign(0.007)TCGA-A2-A0YL-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
GPA33SNVMissense_Mutationc.663N>Gp.Phe221Leup.F221LQ99795protein_codingtolerated(0.09)benign(0.005)TCGA-A8-A06Q-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
GPA33deletionFrame_Shift_Delnovelc.559delCp.Leu187TrpfsTer12p.L187Wfs*12Q99795protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
GPA33SNVMissense_Mutationnovelc.699N>Ap.Met233Ilep.M233IQ99795protein_codingdeleterious(0.01)probably_damaging(0.954)TCGA-EA-A43B-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
GPA33SNVMissense_Mutationnovelc.500G>Ap.Gly167Aspp.G167DQ99795protein_codingdeleterious(0)probably_damaging(1)TCGA-A6-5665-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
GPA33SNVMissense_Mutationc.781N>Cp.Cys261Argp.C261RQ99795protein_codingdeleterious(0)benign(0.387)TCGA-CK-6746-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
GPA33SNVMissense_Mutationc.767N>Cp.Ile256Thrp.I256TQ99795protein_codingdeleterious(0.04)benign(0.037)TCGA-A5-A0GA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVChemotherapytaxolPD
GPA33SNVMissense_Mutationnovelc.634A>Gp.Thr212Alap.T212AQ99795protein_codingdeleterious(0.05)benign(0.187)TCGA-A5-A1OF-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
GPA33SNVMissense_Mutationrs540996886c.674N>Tp.Thr225Metp.T225MQ99795protein_codingdeleterious(0)probably_damaging(0.996)TCGA-A5-A2K3-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIChemotherapycarboplatinSD
GPA33SNVMissense_Mutationnovelc.213N>Gp.Ile71Metp.I71MQ99795protein_codingdeleterious(0.02)possibly_damaging(0.715)TCGA-AJ-A3QS-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
10223GPA33DRUGGABLE GENOMEMGD007MGD-007
10223GPA33DRUGGABLE GENOMEKRN-330KRN-330
10223GPA33DRUGGABLE GENOMEHuA33HUA33
10223GPA33DRUGGABLE GENOMERadiolabelled-huA33
10223GPA33DRUGGABLE GENOMEKRN-330KRN-330
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