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Gene: GORASP1 |
Gene summary for GORASP1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GORASP1 | Gene ID | 64689 |
| Gene name | golgi reassembly stacking protein 1 | |
| Gene Alias | GOLPH5 | |
| Cytomap | 3p22.2 | |
| Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | B3KPY8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64689 | GORASP1 | LZE4T | Human | Esophagus | ESCC | 7.59e-03 | 3.50e-02 | 0.0811 |
| 64689 | GORASP1 | LZE24T | Human | Esophagus | ESCC | 1.77e-10 | 1.23e-01 | 0.0596 |
| 64689 | GORASP1 | LZE6T | Human | Esophagus | ESCC | 1.80e-03 | 1.45e-01 | 0.0845 |
| 64689 | GORASP1 | P1T-E | Human | Esophagus | ESCC | 7.50e-04 | 2.02e-01 | 0.0875 |
| 64689 | GORASP1 | P2T-E | Human | Esophagus | ESCC | 4.03e-16 | 1.07e-01 | 0.1177 |
| 64689 | GORASP1 | P4T-E | Human | Esophagus | ESCC | 7.17e-06 | 1.21e-01 | 0.1323 |
| 64689 | GORASP1 | P5T-E | Human | Esophagus | ESCC | 4.36e-04 | 4.86e-03 | 0.1327 |
| 64689 | GORASP1 | P8T-E | Human | Esophagus | ESCC | 1.86e-17 | 1.53e-01 | 0.0889 |
| 64689 | GORASP1 | P9T-E | Human | Esophagus | ESCC | 1.43e-05 | 9.39e-02 | 0.1131 |
| 64689 | GORASP1 | P10T-E | Human | Esophagus | ESCC | 8.73e-13 | 9.53e-02 | 0.116 |
| 64689 | GORASP1 | P11T-E | Human | Esophagus | ESCC | 6.84e-07 | 1.62e-01 | 0.1426 |
| 64689 | GORASP1 | P12T-E | Human | Esophagus | ESCC | 5.73e-18 | 2.47e-01 | 0.1122 |
| 64689 | GORASP1 | P15T-E | Human | Esophagus | ESCC | 7.75e-05 | 8.25e-02 | 0.1149 |
| 64689 | GORASP1 | P16T-E | Human | Esophagus | ESCC | 8.77e-07 | 7.91e-02 | 0.1153 |
| 64689 | GORASP1 | P17T-E | Human | Esophagus | ESCC | 1.95e-03 | 1.15e-01 | 0.1278 |
| 64689 | GORASP1 | P19T-E | Human | Esophagus | ESCC | 6.62e-03 | 3.00e-01 | 0.1662 |
| 64689 | GORASP1 | P20T-E | Human | Esophagus | ESCC | 9.44e-11 | 1.27e-01 | 0.1124 |
| 64689 | GORASP1 | P21T-E | Human | Esophagus | ESCC | 1.99e-17 | 1.51e-01 | 0.1617 |
| 64689 | GORASP1 | P22T-E | Human | Esophagus | ESCC | 1.37e-10 | 7.36e-02 | 0.1236 |
| 64689 | GORASP1 | P23T-E | Human | Esophagus | ESCC | 2.17e-14 | 2.15e-01 | 0.108 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
| GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
| GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
| GO:000648714 | Esophagus | ESCC | protein N-linked glycosylation | 51/8552 | 65/18723 | 6.41e-08 | 1.13e-06 | 51 |
| GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
| GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
| GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
| GO:006195114 | Esophagus | ESCC | establishment of protein localization to plasma membrane | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
| GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
| GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
| GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
| GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
| GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
| GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
| GO:001635816 | Esophagus | ESCC | dendrite development | 130/8552 | 243/18723 | 8.33e-03 | 2.95e-02 | 130 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GORASP1 | SNV | Missense_Mutation | c.998N>C | p.Leu333Pro | p.L333P | Q9BQQ3 | protein_coding | tolerated(0.14) | benign(0) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
| GORASP1 | insertion | In_Frame_Ins | novel | c.1159_1160insGGG | p.Thr387delinsArgAla | p.T387delinsRA | Q9BQQ3 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
| GORASP1 | insertion | Frame_Shift_Ins | novel | c.1157_1158insCTGGGGGGCACAGGCCAACTATATGGAGG | p.Thr387TrpfsTer45 | p.T387Wfs*45 | Q9BQQ3 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
| GORASP1 | insertion | Frame_Shift_Ins | novel | c.205_206insAAGC | p.Leu69GlnfsTer43 | p.L69Qfs*43 | Q9BQQ3 | protein_coding | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
| GORASP1 | SNV | Missense_Mutation | rs147603751 | c.389G>A | p.Arg130His | p.R130H | Q9BQQ3 | protein_coding | tolerated(0.31) | possibly_damaging(0.69) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| GORASP1 | SNV | Missense_Mutation | c.544N>A | p.Ala182Thr | p.A182T | Q9BQQ3 | protein_coding | tolerated(0.07) | benign(0.112) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| GORASP1 | SNV | Missense_Mutation | rs147603751 | c.389N>A | p.Arg130His | p.R130H | Q9BQQ3 | protein_coding | tolerated(0.31) | possibly_damaging(0.69) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GORASP1 | SNV | Missense_Mutation | c.199N>A | p.Val67Met | p.V67M | Q9BQQ3 | protein_coding | deleterious(0.04) | possibly_damaging(0.673) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
| GORASP1 | SNV | Missense_Mutation | novel | c.633N>T | p.Lys211Asn | p.K211N | Q9BQQ3 | protein_coding | deleterious(0.03) | benign(0.412) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| GORASP1 | SNV | Missense_Mutation | rs766833329 | c.239N>A | p.Arg80His | p.R80H | Q9BQQ3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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