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Gene: GORAB |
Gene summary for GORAB |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GORAB | Gene ID | 92344 |
| Gene name | golgin, RAB6 interacting | |
| Gene Alias | GO | |
| Cytomap | 1q24.2 | |
| Gene Type | protein-coding | GO ID | GO:0001942 | UniProtAcc | Q5T7V8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 92344 | GORAB | LZE4T | Human | Esophagus | ESCC | 1.00e-03 | 1.40e-01 | 0.0811 |
| 92344 | GORAB | LZE7T | Human | Esophagus | ESCC | 6.67e-08 | 3.87e-01 | 0.0667 |
| 92344 | GORAB | LZE8T | Human | Esophagus | ESCC | 2.81e-03 | 1.43e-01 | 0.067 |
| 92344 | GORAB | LZE22T | Human | Esophagus | ESCC | 2.76e-02 | 2.39e-01 | 0.068 |
| 92344 | GORAB | LZE24T | Human | Esophagus | ESCC | 2.07e-04 | 2.00e-01 | 0.0596 |
| 92344 | GORAB | LZE21T | Human | Esophagus | ESCC | 4.86e-05 | 3.32e-01 | 0.0655 |
| 92344 | GORAB | LZE6T | Human | Esophagus | ESCC | 9.54e-03 | 1.43e-01 | 0.0845 |
| 92344 | GORAB | P1T-E | Human | Esophagus | ESCC | 2.09e-04 | 3.01e-01 | 0.0875 |
| 92344 | GORAB | P2T-E | Human | Esophagus | ESCC | 7.24e-23 | 4.38e-01 | 0.1177 |
| 92344 | GORAB | P4T-E | Human | Esophagus | ESCC | 2.93e-18 | 4.19e-01 | 0.1323 |
| 92344 | GORAB | P5T-E | Human | Esophagus | ESCC | 7.54e-12 | 2.43e-01 | 0.1327 |
| 92344 | GORAB | P8T-E | Human | Esophagus | ESCC | 7.28e-07 | 1.58e-01 | 0.0889 |
| 92344 | GORAB | P9T-E | Human | Esophagus | ESCC | 2.57e-11 | 2.72e-01 | 0.1131 |
| 92344 | GORAB | P10T-E | Human | Esophagus | ESCC | 4.13e-20 | 3.61e-01 | 0.116 |
| 92344 | GORAB | P11T-E | Human | Esophagus | ESCC | 1.35e-11 | 3.63e-01 | 0.1426 |
| 92344 | GORAB | P12T-E | Human | Esophagus | ESCC | 2.66e-06 | 1.96e-01 | 0.1122 |
| 92344 | GORAB | P15T-E | Human | Esophagus | ESCC | 1.49e-16 | 4.07e-01 | 0.1149 |
| 92344 | GORAB | P16T-E | Human | Esophagus | ESCC | 1.01e-25 | 4.42e-01 | 0.1153 |
| 92344 | GORAB | P19T-E | Human | Esophagus | ESCC | 4.44e-02 | 2.04e-01 | 0.1662 |
| 92344 | GORAB | P20T-E | Human | Esophagus | ESCC | 7.60e-17 | 3.23e-01 | 0.1124 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00435888 | Esophagus | ESCC | skin development | 163/8552 | 263/18723 | 6.48e-08 | 1.14e-06 | 163 |
| GO:00219159 | Esophagus | ESCC | neural tube development | 101/8552 | 152/18723 | 1.78e-07 | 2.79e-06 | 101 |
| GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
| GO:00224043 | Esophagus | ESCC | molting cycle process | 53/8552 | 84/18723 | 9.62e-04 | 4.88e-03 | 53 |
| GO:00224053 | Esophagus | ESCC | hair cycle process | 53/8552 | 84/18723 | 9.62e-04 | 4.88e-03 | 53 |
| GO:0001942 | Esophagus | ESCC | hair follicle development | 51/8552 | 81/18723 | 1.27e-03 | 6.14e-03 | 51 |
| GO:0098773 | Esophagus | ESCC | skin epidermis development | 53/8552 | 85/18723 | 1.43e-03 | 6.77e-03 | 53 |
| GO:00423033 | Esophagus | ESCC | molting cycle | 64/8552 | 107/18723 | 2.24e-03 | 9.85e-03 | 64 |
| GO:00426333 | Esophagus | ESCC | hair cycle | 64/8552 | 107/18723 | 2.24e-03 | 9.85e-03 | 64 |
| GO:19055153 | Esophagus | ESCC | non-motile cilium assembly | 39/8552 | 61/18723 | 3.08e-03 | 1.28e-02 | 39 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0411524 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
| hsa0411534 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GORAB | SNV | Missense_Mutation | novel | c.101N>T | p.Ser34Phe | p.S34F | Q5T7V8 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
| GORAB | SNV | Missense_Mutation | c.31N>A | p.Ala11Thr | p.A11T | Q5T7V8 | protein_coding | tolerated_low_confidence(0.13) | benign(0.006) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| GORAB | SNV | Missense_Mutation | c.454N>T | p.Pro152Ser | p.P152S | Q5T7V8 | protein_coding | tolerated(0.11) | benign(0.014) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| GORAB | SNV | Missense_Mutation | c.454N>A | p.Pro152Thr | p.P152T | Q5T7V8 | protein_coding | tolerated(0.08) | benign(0.014) | TCGA-BH-A0GZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
| GORAB | SNV | Missense_Mutation | rs200615427 | c.836N>T | p.Thr279Met | p.T279M | Q5T7V8 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR |
| GORAB | SNV | Missense_Mutation | c.149C>T | p.Pro50Leu | p.P50L | Q5T7V8 | protein_coding | tolerated(0.08) | probably_damaging(0.943) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD | |
| GORAB | SNV | Missense_Mutation | novel | c.833N>T | p.Cys278Phe | p.C278F | Q5T7V8 | protein_coding | tolerated(0.1) | benign(0.219) | TCGA-5M-AAT4-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
| GORAB | SNV | Missense_Mutation | novel | c.742N>T | p.Arg248Trp | p.R248W | Q5T7V8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-6654-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
| GORAB | SNV | Missense_Mutation | c.171G>T | p.Lys57Asn | p.K57N | Q5T7V8 | protein_coding | tolerated(0.49) | benign(0.003) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| GORAB | SNV | Missense_Mutation | c.549N>T | p.Glu183Asp | p.E183D | Q5T7V8 | protein_coding | deleterious(0.04) | possibly_damaging(0.783) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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