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Gene: GON7 |
Gene summary for GON7 |
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Gene information | Species | Human | Gene symbol | GON7 | Gene ID | 84520 |
Gene name | GON7 subunit of KEOPS complex | |
Gene Alias | C14orf142 | |
Cytomap | 14q32.12 | |
Gene Type | protein-coding | GO ID | GO:0000408 | UniProtAcc | Q9BXV9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84520 | GON7 | HCC2 | Human | Liver | HCC | 6.24e-03 | 2.08e+00 | 0.5341 |
84520 | GON7 | S014 | Human | Liver | HCC | 2.09e-19 | 5.18e-01 | 0.2254 |
84520 | GON7 | S015 | Human | Liver | HCC | 6.70e-19 | 6.54e-01 | 0.2375 |
84520 | GON7 | S016 | Human | Liver | HCC | 2.14e-18 | 5.44e-01 | 0.2243 |
84520 | GON7 | S027 | Human | Liver | HCC | 4.29e-04 | 3.39e-01 | 0.2446 |
84520 | GON7 | S028 | Human | Liver | HCC | 6.15e-13 | 3.96e-01 | 0.2503 |
84520 | GON7 | S029 | Human | Liver | HCC | 2.88e-12 | 4.02e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GON7 | SNV | Missense_Mutation | novel | c.11T>A | p.Leu4Gln | p.L4Q | Q9BXV9 | protein_coding | tolerated(0.16) | possibly_damaging(0.668) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GON7 | SNV | Missense_Mutation | rs766704950 | c.296N>T | p.Pro99Leu | p.P99L | Q9BXV9 | protein_coding | tolerated(0.06) | benign(0.029) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GON7 | SNV | Missense_Mutation | rs779654694 | c.226G>A | p.Ala76Thr | p.A76T | Q9BXV9 | protein_coding | tolerated(0.18) | benign(0.294) | TCGA-D1-A0ZO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GON7 | SNV | Missense_Mutation | novel | c.254N>T | p.Arg85Ile | p.R85I | Q9BXV9 | protein_coding | deleterious(0.01) | benign(0.046) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GON7 | SNV | Missense_Mutation | novel | c.64N>C | p.Glu22Gln | p.E22Q | Q9BXV9 | protein_coding | tolerated(0.08) | benign(0.059) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
GON7 | SNV | Missense_Mutation | novel | c.44A>T | p.Gln15Leu | p.Q15L | Q9BXV9 | protein_coding | deleterious(0.03) | benign(0.031) | TCGA-CV-7254-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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