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Gene: GOLGA7B |
Gene summary for GOLGA7B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GOLGA7B | Gene ID | 401647 |
| Gene name | golgin A7 family member B | |
| Gene Alias | C10orf132 | |
| Cytomap | 10q24.2 | |
| Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q2TAP0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 401647 | GOLGA7B | C04 | Human | Oral cavity | OSCC | 5.77e-08 | 3.43e-01 | 0.2633 |
| 401647 | GOLGA7B | C21 | Human | Oral cavity | OSCC | 5.82e-05 | 1.96e-01 | 0.2678 |
| 401647 | GOLGA7B | C30 | Human | Oral cavity | OSCC | 2.88e-31 | 1.17e+00 | 0.3055 |
| 401647 | GOLGA7B | C51 | Human | Oral cavity | OSCC | 1.35e-12 | 5.99e-01 | 0.2674 |
| 401647 | GOLGA7B | C06 | Human | Oral cavity | OSCC | 1.68e-08 | 1.01e+00 | 0.2699 |
| 401647 | GOLGA7B | SYSMH2 | Human | Oral cavity | OSCC | 2.07e-05 | 1.52e-01 | 0.2326 |
| 401647 | GOLGA7B | SYSMH3 | Human | Oral cavity | OSCC | 1.47e-18 | 4.03e-01 | 0.2442 |
| 401647 | GOLGA7B | SYSMH5 | Human | Oral cavity | OSCC | 2.75e-09 | 2.01e-01 | 0.0647 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000660520 | Oral cavity | OSCC | protein targeting | 204/7305 | 314/18723 | 6.78e-21 | 1.13e-18 | 204 |
| GO:009015018 | Oral cavity | OSCC | establishment of protein localization to membrane | 163/7305 | 260/18723 | 7.13e-15 | 4.47e-13 | 163 |
| GO:00435434 | Oral cavity | OSCC | protein acylation | 149/7305 | 243/18723 | 1.33e-12 | 5.80e-11 | 149 |
| GO:00421572 | Oral cavity | OSCC | lipoprotein metabolic process | 77/7305 | 135/18723 | 1.61e-05 | 1.60e-04 | 77 |
| GO:00066123 | Oral cavity | OSCC | protein targeting to membrane | 75/7305 | 131/18723 | 1.72e-05 | 1.69e-04 | 75 |
| GO:00064972 | Oral cavity | OSCC | protein lipidation | 56/7305 | 92/18723 | 1.77e-05 | 1.72e-04 | 56 |
| GO:00421582 | Oral cavity | OSCC | lipoprotein biosynthetic process | 57/7305 | 96/18723 | 4.17e-05 | 3.61e-04 | 57 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GOLGA7B | SNV | Missense_Mutation | novel | c.306N>G | p.Ile102Met | p.I102M | Q2TAP0 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GOLGA7B | SNV | Missense_Mutation | c.397N>C | p.Glu133Gln | p.E133Q | Q2TAP0 | protein_coding | deleterious(0.01) | benign(0.399) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
| GOLGA7B | SNV | Missense_Mutation | c.358C>A | p.Leu120Ile | p.L120I | Q2TAP0 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| GOLGA7B | SNV | Missense_Mutation | c.269N>A | p.Cys90Tyr | p.C90Y | Q2TAP0 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| GOLGA7B | SNV | Missense_Mutation | rs761671560 | c.38N>A | p.Arg13Gln | p.R13Q | Q2TAP0 | protein_coding | tolerated(0.5) | benign(0.078) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| GOLGA7B | SNV | Missense_Mutation | c.248C>T | p.Thr83Met | p.T83M | Q2TAP0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-A026-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| GOLGA7B | SNV | Missense_Mutation | c.76N>T | p.Asp26Tyr | p.D26Y | Q2TAP0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| GOLGA7B | SNV | Missense_Mutation | novel | c.367N>T | p.Asp123Tyr | p.D123Y | Q2TAP0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GOLGA7B | SNV | Missense_Mutation | novel | c.276N>T | p.Glu92Asp | p.E92D | Q2TAP0 | protein_coding | tolerated(0.16) | probably_damaging(0.973) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| GOLGA7B | SNV | Missense_Mutation | c.27N>T | p.Gln9His | p.Q9H | Q2TAP0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.948) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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