Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: GOLGA3

Gene summary for GOLGA3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

GOLGA3

Gene ID

2802

Gene namegolgin A3
Gene AliasGCP170
Cytomap12q24.33
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

Q08378


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
2802GOLGA3LZE2THumanEsophagusESCC2.44e-023.60e-010.082
2802GOLGA3LZE4THumanEsophagusESCC1.51e-031.18e-010.0811
2802GOLGA3LZE5THumanEsophagusESCC3.45e-032.81e-010.0514
2802GOLGA3LZE7THumanEsophagusESCC2.03e-033.91e-010.0667
2802GOLGA3LZE24THumanEsophagusESCC2.19e-093.30e-010.0596
2802GOLGA3LZE6THumanEsophagusESCC1.67e-041.33e-010.0845
2802GOLGA3P1T-EHumanEsophagusESCC7.68e-104.08e-010.0875
2802GOLGA3P2T-EHumanEsophagusESCC2.59e-233.92e-010.1177
2802GOLGA3P4T-EHumanEsophagusESCC4.23e-173.66e-010.1323
2802GOLGA3P5T-EHumanEsophagusESCC3.92e-142.36e-010.1327
2802GOLGA3P8T-EHumanEsophagusESCC1.95e-244.18e-010.0889
2802GOLGA3P9T-EHumanEsophagusESCC8.72e-111.98e-010.1131
2802GOLGA3P10T-EHumanEsophagusESCC6.46e-233.88e-010.116
2802GOLGA3P11T-EHumanEsophagusESCC5.40e-143.98e-010.1426
2802GOLGA3P12T-EHumanEsophagusESCC1.83e-111.39e-010.1122
2802GOLGA3P15T-EHumanEsophagusESCC5.77e-112.03e-010.1149
2802GOLGA3P16T-EHumanEsophagusESCC2.13e-081.83e-010.1153
2802GOLGA3P17T-EHumanEsophagusESCC1.55e-064.15e-010.1278
2802GOLGA3P19T-EHumanEsophagusESCC5.91e-055.43e-010.1662
2802GOLGA3P20T-EHumanEsophagusESCC5.95e-132.86e-010.1124
Page: 1 2 3 4 5 6 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
Page: 1 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
GOLGA3SNVMissense_Mutationc.274N>Tp.Asp92Tyrp.D92YQ08378protein_codingdeleterious_low_confidence(0)probably_damaging(0.939)TCGA-A1-A0SM-01Breastbreast invasive carcinomaMale>=65I/IIUnknownUnknownSD
GOLGA3SNVMissense_Mutationc.4012N>Cp.Asp1338Hisp.D1338HQ08378protein_codingdeleterious(0.01)possibly_damaging(0.885)TCGA-A8-A07O-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyCR
GOLGA3SNVMissense_Mutationc.1407N>Tp.Glu469Aspp.E469DQ08378protein_codingtolerated(0.19)possibly_damaging(0.51)TCGA-A8-A092-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapypaclitaxelCR
GOLGA3SNVMissense_Mutationc.4004N>Tp.Ala1335Valp.A1335VQ08378protein_codingtolerated(1)benign(0.003)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
GOLGA3SNVMissense_Mutationrs371111883c.1697N>Tp.Ala566Valp.A566VQ08378protein_codingdeleterious(0.02)possibly_damaging(0.655)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
GOLGA3SNVMissense_Mutationc.166N>Ap.Glu56Lysp.E56KQ08378protein_codingtolerated_low_confidence(0.42)benign(0.003)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
GOLGA3SNVMissense_Mutationnovelc.2186C>Tp.Thr729Ilep.T729IQ08378protein_codingdeleterious(0.03)benign(0.084)TCGA-AN-A0FX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
GOLGA3SNVMissense_Mutationnovelc.3829N>Tp.Ser1277Cysp.S1277CQ08378protein_codingdeleterious(0)possibly_damaging(0.569)TCGA-AR-A0TY-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificPaclitaxelPD
GOLGA3SNVMissense_Mutationc.2532N>Tp.Gln844Hisp.Q844HQ08378protein_codingdeleterious(0)probably_damaging(0.999)TCGA-BH-A0AW-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycarboplatinSD
GOLGA3SNVMissense_Mutationnovelc.3627N>Gp.Phe1209Leup.F1209LQ08378protein_codingtolerated(0.28)benign(0.356)TCGA-BH-A2L8-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanCR
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1