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Gene: GNA14 |
Gene summary for GNA14 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GNA14 | Gene ID | 9630 |
| Gene name | G protein subunit alpha 14 | |
| Gene Alias | GNA14 | |
| Cytomap | 9q21.2 | |
| Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | O95837 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9630 | GNA14 | RNA-P17T-P17T-2 | Human | Lung | IAC | 3.94e-02 | 4.85e-01 | 0.3371 |
| 9630 | GNA14 | RNA-P17T-P17T-6 | Human | Lung | IAC | 8.33e-04 | 6.27e-01 | 0.3385 |
| 9630 | GNA14 | RNA-P18T-P18T-2 | Human | Lung | IAC | 3.06e-06 | 1.23e+00 | 0.1129 |
| 9630 | GNA14 | RNA-P18T-P18T-6 | Human | Lung | IAC | 1.73e-02 | 9.73e-01 | 0.0856 |
| 9630 | GNA14 | RNA-P18T-P18T-8 | Human | Lung | IAC | 4.26e-03 | 1.01e+00 | 0.1151 |
| 9630 | GNA14 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.25e-03 | 2.13e-01 | -0.0166 |
| 9630 | GNA14 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.52e-07 | 3.29e-01 | -0.0132 |
| 9630 | GNA14 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.33e-06 | 3.01e-01 | -0.013 |
| 9630 | GNA14 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.07e-07 | 3.35e-01 | -0.0121 |
| 9630 | GNA14 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 2.32e-02 | 4.25e-01 | -0.0809 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa051464 | Lung | IAC | Amoebiasis | 23/1053 | 102/8465 | 2.99e-03 | 1.53e-02 | 1.02e-02 | 23 |
| hsa051422 | Lung | IAC | Chagas disease | 21/1053 | 102/8465 | 1.30e-02 | 4.57e-02 | 3.04e-02 | 21 |
| hsa0514611 | Lung | IAC | Amoebiasis | 23/1053 | 102/8465 | 2.99e-03 | 1.53e-02 | 1.02e-02 | 23 |
| hsa0514211 | Lung | IAC | Chagas disease | 21/1053 | 102/8465 | 1.30e-02 | 4.57e-02 | 3.04e-02 | 21 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GNA14 | SNV | Missense_Mutation | c.809A>T | p.Asn270Ile | p.N270I | O95837 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
| GNA14 | SNV | Missense_Mutation | novel | c.396G>T | p.Trp132Cys | p.W132C | O95837 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-S3-AA10-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
| GNA14 | insertion | Nonsense_Mutation | novel | c.493_494insAGGGTATTTAGAATTGTGGTAGGTAGGT | p.Thr165LysfsTer4 | p.T165Kfs*4 | O95837 | protein_coding | TCGA-AN-A041-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| GNA14 | insertion | Frame_Shift_Ins | novel | c.460_461insCACATCAAAGTACAGCAAAAACAGTGAT | p.Lys154ThrfsTer15 | p.K154Tfs*15 | O95837 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| GNA14 | SNV | Missense_Mutation | c.341N>C | p.Val114Ala | p.V114A | O95837 | protein_coding | tolerated(0.76) | benign(0.018) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| GNA14 | SNV | Missense_Mutation | rs545966792 | c.529N>T | p.Arg177Cys | p.R177C | O95837 | protein_coding | deleterious(0.01) | possibly_damaging(0.818) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GNA14 | SNV | Missense_Mutation | c.265N>A | p.Ala89Thr | p.A89T | O95837 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| GNA14 | SNV | Missense_Mutation | novel | c.83N>G | p.Asp28Gly | p.D28G | O95837 | protein_coding | deleterious(0.01) | benign(0.11) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| GNA14 | SNV | Missense_Mutation | c.272N>T | p.Asp91Val | p.D91V | O95837 | protein_coding | tolerated(0.11) | benign(0.05) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| GNA14 | SNV | Missense_Mutation | c.390N>C | p.Gln130His | p.Q130H | O95837 | protein_coding | tolerated(0.14) | benign(0) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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