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Gene: GLTPD2 |
Gene summary for GLTPD2 |
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Gene information | Species | Human | Gene symbol | GLTPD2 | Gene ID | 388323 |
Gene name | glycolipid transfer protein domain containing 2 | |
Gene Alias | GLTPD2 | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388323 | GLTPD2 | HCC1_Meng | Human | Liver | HCC | 9.52e-66 | 3.15e-01 | 0.0246 |
388323 | GLTPD2 | HCC1 | Human | Liver | HCC | 1.89e-02 | 9.56e-01 | 0.5336 |
388323 | GLTPD2 | S014 | Human | Liver | HCC | 4.08e-23 | 6.34e-01 | 0.2254 |
388323 | GLTPD2 | S015 | Human | Liver | HCC | 3.85e-19 | 6.14e-01 | 0.2375 |
388323 | GLTPD2 | S016 | Human | Liver | HCC | 6.34e-19 | 4.97e-01 | 0.2243 |
388323 | GLTPD2 | S029 | Human | Liver | HCC | 3.09e-09 | 3.22e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:01200092 | Liver | HCC | intermembrane lipid transfer | 33/7958 | 48/18723 | 2.12e-04 | 1.63e-03 | 33 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLTPD2 | SNV | Missense_Mutation | novel | c.415N>T | p.Arg139Trp | p.R139W | A6NH11 | protein_coding | tolerated(0.18) | possibly_damaging(0.825) | TCGA-B6-A40C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | cyclophosphamide | SD |
GLTPD2 | SNV | Missense_Mutation | rs777488983 | c.71N>T | p.Ala24Val | p.A24V | A6NH11 | protein_coding | tolerated_low_confidence(0.66) | benign(0.001) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GLTPD2 | SNV | Missense_Mutation | rs777488983 | c.71C>T | p.Ala24Val | p.A24V | A6NH11 | protein_coding | tolerated_low_confidence(0.66) | benign(0.001) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GLTPD2 | SNV | Missense_Mutation | c.200C>T | p.Ala67Val | p.A67V | A6NH11 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
GLTPD2 | deletion | Frame_Shift_Del | c.23delC | p.Pro8GlnfsTer28 | p.P8Qfs*28 | A6NH11 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
GLTPD2 | SNV | Missense_Mutation | novel | c.158N>T | p.Thr53Met | p.T53M | A6NH11 | protein_coding | deleterious_low_confidence(0.02) | benign(0.058) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GLTPD2 | SNV | Missense_Mutation | c.112N>T | p.Arg38Cys | p.R38C | A6NH11 | protein_coding | tolerated(0.07) | benign(0.284) | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | |
GLTPD2 | SNV | Missense_Mutation | c.82C>T | p.Leu28Phe | p.L28F | A6NH11 | protein_coding | tolerated_low_confidence(0.13) | benign(0.001) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
GLTPD2 | SNV | Missense_Mutation | c.97N>T | p.Arg33Trp | p.R33W | A6NH11 | protein_coding | tolerated_low_confidence(0.16) | benign(0) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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