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Gene: GLT8D2 |
Gene summary for GLT8D2 |
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Gene information | Species | Human | Gene symbol | GLT8D2 | Gene ID | 83468 |
Gene name | glycosyltransferase 8 domain containing 2 | |
Gene Alias | GLT8D2 | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H1C3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83468 | GLT8D2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.38e-10 | 2.42e-01 | 0.0155 |
83468 | GLT8D2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.36e-22 | 6.36e-01 | -0.1808 |
83468 | GLT8D2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.44e-34 | 8.93e-01 | -0.0811 |
83468 | GLT8D2 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.91e-33 | 7.10e-01 | -0.1088 |
83468 | GLT8D2 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.37e-45 | 7.78e-01 | -0.1954 |
83468 | GLT8D2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.54e-19 | 1.13e+00 | -0.2602 |
83468 | GLT8D2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.88e-11 | 7.70e-01 | -0.2196 |
83468 | GLT8D2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.32e-14 | 6.26e-01 | -0.1207 |
83468 | GLT8D2 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.83e-15 | 6.11e-01 | -0.1526 |
83468 | GLT8D2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.21e-31 | 5.52e-01 | -0.1464 |
83468 | GLT8D2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.09e-16 | 3.22e-01 | -0.1001 |
83468 | GLT8D2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.57e-29 | 8.95e-01 | -0.059 |
83468 | GLT8D2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.53e-17 | 8.43e-01 | -0.1706 |
83468 | GLT8D2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.35e-23 | 9.29e-01 | -0.2061 |
83468 | GLT8D2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.20e-12 | 6.47e-01 | -0.1462 |
83468 | GLT8D2 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-07 | 3.42e-01 | -0.0842 |
83468 | GLT8D2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.79e-05 | 2.30e-01 | -0.0179 |
83468 | GLT8D2 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.40e-16 | 4.44e-01 | 0.096 |
83468 | GLT8D2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.03e-06 | 3.31e-01 | 0.0446 |
83468 | GLT8D2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.13e-05 | 3.03e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLT8D2 | SNV | Missense_Mutation | rs751805819 | c.278N>A | p.Arg93Gln | p.R93Q | Q9H1C3 | protein_coding | tolerated(0.12) | benign(0.131) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLT8D2 | SNV | Missense_Mutation | c.14N>A | p.Arg5Gln | p.R5Q | Q9H1C3 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-BH-A18U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GLT8D2 | SNV | Missense_Mutation | c.727N>T | p.Ile243Phe | p.I243F | Q9H1C3 | protein_coding | deleterious(0) | possibly_damaging(0.599) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GLT8D2 | SNV | Missense_Mutation | rs775838336 | c.448N>A | p.Glu150Lys | p.E150K | Q9H1C3 | protein_coding | tolerated(0.49) | benign(0.033) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GLT8D2 | SNV | Missense_Mutation | rs150432657 | c.589G>A | p.Val197Met | p.V197M | Q9H1C3 | protein_coding | tolerated(0.12) | possibly_damaging(0.873) | TCGA-CK-4947-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Other, specify in notes | folinic | SD |
GLT8D2 | SNV | Missense_Mutation | novel | c.165N>G | p.Ile55Met | p.I55M | Q9H1C3 | protein_coding | deleterious(0.02) | possibly_damaging(0.776) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GLT8D2 | SNV | Missense_Mutation | novel | c.246C>A | p.Phe82Leu | p.F82L | Q9H1C3 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
GLT8D2 | SNV | Missense_Mutation | rs367887581 | c.380C>T | p.Ser127Leu | p.S127L | Q9H1C3 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GLT8D2 | SNV | Missense_Mutation | c.1001N>T | p.Trp334Leu | p.W334L | Q9H1C3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GLT8D2 | SNV | Missense_Mutation | novel | c.509A>G | p.Asp170Gly | p.D170G | Q9H1C3 | protein_coding | tolerated(0.06) | possibly_damaging(0.468) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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