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Gene: GLIPR1 |
Gene summary for GLIPR1 |
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Gene information | Species | Human | Gene symbol | GLIPR1 | Gene ID | 11010 |
Gene name | GLI pathogenesis related 1 | |
Gene Alias | CRISP7 | |
Cytomap | 12q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000323 | UniProtAcc | P48060 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11010 | GLIPR1 | AEH-subject1 | Human | Endometrium | AEH | 1.47e-10 | -4.44e-01 | -0.3059 |
11010 | GLIPR1 | AEH-subject2 | Human | Endometrium | AEH | 3.44e-15 | -4.52e-01 | -0.2525 |
11010 | GLIPR1 | AEH-subject3 | Human | Endometrium | AEH | 6.75e-12 | -4.43e-01 | -0.2576 |
11010 | GLIPR1 | AEH-subject4 | Human | Endometrium | AEH | 9.32e-06 | -3.66e-01 | -0.2657 |
11010 | GLIPR1 | AEH-subject5 | Human | Endometrium | AEH | 3.84e-10 | -4.60e-01 | -0.2953 |
11010 | GLIPR1 | EEC-subject1 | Human | Endometrium | EEC | 3.44e-17 | -4.73e-01 | -0.2682 |
11010 | GLIPR1 | EEC-subject2 | Human | Endometrium | EEC | 5.98e-21 | -4.93e-01 | -0.2607 |
11010 | GLIPR1 | EEC-subject3 | Human | Endometrium | EEC | 8.21e-10 | -4.23e-01 | -0.2525 |
11010 | GLIPR1 | EEC-subject4 | Human | Endometrium | EEC | 1.83e-08 | -3.95e-01 | -0.2571 |
11010 | GLIPR1 | EEC-subject5 | Human | Endometrium | EEC | 1.94e-10 | -4.39e-01 | -0.249 |
11010 | GLIPR1 | GSM5276935 | Human | Endometrium | EEC | 2.57e-12 | -4.79e-01 | -0.123 |
11010 | GLIPR1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.84e-15 | -4.34e-01 | -0.1869 |
11010 | GLIPR1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 7.71e-13 | -4.28e-01 | -0.1875 |
11010 | GLIPR1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 4.31e-15 | -4.65e-01 | -0.1883 |
11010 | GLIPR1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 6.63e-21 | -4.51e-01 | -0.1934 |
11010 | GLIPR1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.98e-24 | -5.05e-01 | -0.1917 |
11010 | GLIPR1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.89e-24 | -4.91e-01 | -0.1916 |
11010 | GLIPR1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.71e-05 | -3.90e-01 | -0.1269 |
11010 | GLIPR1 | LZE4T | Human | Esophagus | ESCC | 3.31e-07 | 4.93e-01 | 0.0811 |
11010 | GLIPR1 | LZE7T | Human | Esophagus | ESCC | 6.56e-04 | 3.15e-01 | 0.0667 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLIPR1 | SNV | Missense_Mutation | rs760892233 | c.337N>A | p.Ala113Thr | p.A113T | P48060 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLIPR1 | SNV | Missense_Mutation | novel | c.166N>A | p.Leu56Ile | p.L56I | P48060 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GLIPR1 | SNV | Missense_Mutation | c.709N>C | p.Phe237Leu | p.F237L | P48060 | protein_coding | tolerated(0.23) | benign(0.079) | TCGA-EK-A2RO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GLIPR1 | SNV | Missense_Mutation | c.79N>A | p.Asp27Asn | p.D27N | P48060 | protein_coding | deleterious(0.03) | benign(0.118) | TCGA-Q1-A6DV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GLIPR1 | SNV | Missense_Mutation | novel | c.251N>G | p.Lys84Arg | p.K84R | P48060 | protein_coding | tolerated(0.14) | benign(0.042) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GLIPR1 | SNV | Missense_Mutation | rs139100030 | c.386G>A | p.Arg129Gln | p.R129Q | P48060 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-A6-A566-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | PD |
GLIPR1 | SNV | Missense_Mutation | rs773209636 | c.38N>A | p.Ser13Tyr | p.S13Y | P48060 | protein_coding | tolerated(0.35) | benign(0.047) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GLIPR1 | SNV | Missense_Mutation | c.160N>T | p.Asp54Tyr | p.D54Y | P48060 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CM-6168-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GLIPR1 | SNV | Missense_Mutation | c.203N>T | p.Ala68Val | p.A68V | P48060 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GLIPR1 | SNV | Missense_Mutation | rs760375651 | c.85N>A | p.Glu29Lys | p.E29K | P48060 | protein_coding | tolerated(0.34) | benign(0) | TCGA-AG-A036-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11010 | GLIPR1 | NA | AdRTVP-1 |
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