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Gene: GLCCI1 |
Gene summary for GLCCI1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GLCCI1 | Gene ID | 113263 |
Gene name | glucocorticoid induced 1 | |
Gene Alias | FAM117C | |
Cytomap | 7p21.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q86VQ1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
113263 | GLCCI1 | TD9 | Human | Lung | IAC | 1.48e-03 | 6.17e-01 | 0.088 |
113263 | GLCCI1 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 9.49e-04 | 1.02e+00 | -0.1406 |
113263 | GLCCI1 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.17e-08 | 1.15e+00 | -0.1408 |
113263 | GLCCI1 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 4.48e-04 | 1.07e+00 | -0.138 |
113263 | GLCCI1 | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.53e-04 | 5.00e-01 | 0.3371 |
113263 | GLCCI1 | RNA-P17T-P17T-4 | Human | Lung | IAC | 3.00e-05 | 4.92e-01 | 0.343 |
113263 | GLCCI1 | RNA-P17T-P17T-6 | Human | Lung | IAC | 3.55e-05 | 5.12e-01 | 0.3385 |
113263 | GLCCI1 | RNA-P17T-P17T-8 | Human | Lung | IAC | 4.11e-04 | 4.17e-01 | 0.3329 |
113263 | GLCCI1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.00e-32 | 1.34e+00 | -0.2116 |
113263 | GLCCI1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 3.98e-07 | 1.03e+00 | -0.1941 |
113263 | GLCCI1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 3.89e-16 | 1.22e+00 | -0.2107 |
113263 | GLCCI1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.80e-25 | 1.31e+00 | -0.2119 |
113263 | GLCCI1 | RNA-P3T-P3T-1 | Human | Lung | IAC | 2.29e-02 | 3.26e-01 | 0.1829 |
113263 | GLCCI1 | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 2.54e-03 | 9.79e-01 | -0.0186 |
113263 | GLCCI1 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 1.17e-02 | 1.22e+00 | -0.0296 |
113263 | GLCCI1 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 3.19e-09 | 1.37e+00 | -0.0263 |
113263 | GLCCI1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.08e-22 | 7.08e-01 | -0.0166 |
113263 | GLCCI1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 4.46e-27 | 7.53e-01 | -0.0132 |
113263 | GLCCI1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.48e-24 | 6.46e-01 | -0.013 |
113263 | GLCCI1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.73e-25 | 7.35e-01 | -0.0121 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLCCI1 | SNV | Missense_Mutation | novel | c.986N>T | p.Gly329Val | p.G329V | Q86VQ1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |
GLCCI1 | SNV | Missense_Mutation | novel | c.625G>A | p.Ala209Thr | p.A209T | Q86VQ1 | protein_coding | tolerated(0.15) | benign(0.112) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
GLCCI1 | SNV | Missense_Mutation | c.904N>G | p.Ile302Val | p.I302V | Q86VQ1 | protein_coding | deleterious(0.05) | possibly_damaging(0.812) | TCGA-BH-A18I-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
GLCCI1 | SNV | Missense_Mutation | rs752605521 | c.1511N>T | p.Thr504Met | p.T504M | Q86VQ1 | protein_coding | deleterious(0.04) | possibly_damaging(0.674) | TCGA-E9-A244-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
GLCCI1 | insertion | Frame_Shift_Ins | novel | c.1616_1617insTGGAGATTTTG | p.Ser540GlyfsTer10 | p.S540Gfs*10 | Q86VQ1 | protein_coding | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GLCCI1 | insertion | In_Frame_Ins | novel | c.1617_1618insATGTCTTCTAGTAGCAAAAATACAAAT | p.Ile539_Ser540insMetSerSerSerSerLysAsnThrAsn | p.I539_S540insMSSSSKNTN | Q86VQ1 | protein_coding | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GLCCI1 | deletion | Frame_Shift_Del | c.871_872delNN | p.Ser291CysfsTer14 | p.S291Cfs*14 | Q86VQ1 | protein_coding | TCGA-BH-A209-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
GLCCI1 | SNV | Missense_Mutation | novel | c.1298C>T | p.Ala433Val | p.A433V | Q86VQ1 | protein_coding | tolerated(0.2) | benign(0.176) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GLCCI1 | SNV | Missense_Mutation | c.633N>T | p.Glu211Asp | p.E211D | Q86VQ1 | protein_coding | tolerated(0.16) | probably_damaging(0.98) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
GLCCI1 | SNV | Missense_Mutation | novel | c.461N>G | p.Asp154Gly | p.D154G | Q86VQ1 | protein_coding | tolerated(0.08) | possibly_damaging(0.879) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
113263 | GLCCI1 | NA | nedocromil | NEDOCROMIL | 21991891 | |
113263 | GLCCI1 | NA | budesonide | BUDESONIDE | 21991891 | |
113263 | GLCCI1 | NA | fluticasone propionate | 21991891 | ||
113263 | GLCCI1 | NA | triamcinolone | TRIAMCINOLONE | 21991891 | |
113263 | GLCCI1 | NA | glucocorticoids | 21991891 | ||
113263 | GLCCI1 | NA | flunisolide | FLUNISOLIDE | 21991891 |
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