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Gene: GK5 |
Gene summary for GK5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GK5 | Gene ID | 256356 |
| Gene name | glycerol kinase 5 | |
| Gene Alias | GK5 | |
| Cytomap | 3q23 | |
| Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q6ZS86 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 256356 | GK5 | CCI_2 | Human | Cervix | CC | 2.58e-03 | 5.45e-01 | 0.5249 |
| 256356 | GK5 | CCI_3 | Human | Cervix | CC | 1.73e-02 | 4.31e-01 | 0.516 |
| 256356 | GK5 | LZE2T | Human | Esophagus | ESCC | 5.29e-03 | 4.84e-01 | 0.082 |
| 256356 | GK5 | LZE4T | Human | Esophagus | ESCC | 3.72e-07 | 2.87e-01 | 0.0811 |
| 256356 | GK5 | LZE7T | Human | Esophagus | ESCC | 1.21e-07 | 4.46e-01 | 0.0667 |
| 256356 | GK5 | LZE8T | Human | Esophagus | ESCC | 2.41e-07 | 1.81e-01 | 0.067 |
| 256356 | GK5 | LZE24T | Human | Esophagus | ESCC | 2.50e-20 | 5.09e-01 | 0.0596 |
| 256356 | GK5 | LZE6T | Human | Esophagus | ESCC | 8.70e-03 | 1.74e-01 | 0.0845 |
| 256356 | GK5 | P1T-E | Human | Esophagus | ESCC | 8.85e-08 | 4.49e-01 | 0.0875 |
| 256356 | GK5 | P2T-E | Human | Esophagus | ESCC | 4.05e-32 | 5.07e-01 | 0.1177 |
| 256356 | GK5 | P4T-E | Human | Esophagus | ESCC | 1.85e-04 | 1.72e-01 | 0.1323 |
| 256356 | GK5 | P5T-E | Human | Esophagus | ESCC | 7.90e-03 | 6.64e-02 | 0.1327 |
| 256356 | GK5 | P8T-E | Human | Esophagus | ESCC | 6.09e-24 | 4.16e-01 | 0.0889 |
| 256356 | GK5 | P9T-E | Human | Esophagus | ESCC | 3.76e-05 | 1.91e-01 | 0.1131 |
| 256356 | GK5 | P10T-E | Human | Esophagus | ESCC | 7.33e-27 | 4.38e-01 | 0.116 |
| 256356 | GK5 | P11T-E | Human | Esophagus | ESCC | 6.42e-07 | 2.35e-01 | 0.1426 |
| 256356 | GK5 | P12T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.82e-01 | 0.1122 |
| 256356 | GK5 | P15T-E | Human | Esophagus | ESCC | 9.51e-10 | 2.75e-01 | 0.1149 |
| 256356 | GK5 | P16T-E | Human | Esophagus | ESCC | 9.03e-13 | 3.15e-01 | 0.1153 |
| 256356 | GK5 | P20T-E | Human | Esophagus | ESCC | 1.30e-17 | 4.88e-01 | 0.1124 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
| GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
| GO:001605216 | Esophagus | ESCC | carbohydrate catabolic process | 91/8552 | 154/18723 | 5.39e-04 | 2.97e-03 | 91 |
| GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
| GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
| GO:00442751 | Esophagus | ESCC | cellular carbohydrate catabolic process | 27/8552 | 40/18723 | 4.39e-03 | 1.73e-02 | 27 |
| GO:004428221 | Liver | HCC | small molecule catabolic process | 225/7958 | 376/18723 | 6.50e-12 | 2.80e-10 | 225 |
| GO:000606621 | Liver | HCC | alcohol metabolic process | 208/7958 | 353/18723 | 2.80e-10 | 9.50e-09 | 208 |
| GO:001605222 | Liver | HCC | carbohydrate catabolic process | 99/7958 | 154/18723 | 3.79e-08 | 8.30e-07 | 99 |
| GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
| GO:004426221 | Liver | HCC | cellular carbohydrate metabolic process | 153/7958 | 283/18723 | 5.27e-05 | 5.00e-04 | 153 |
| GO:00066412 | Liver | HCC | triglyceride metabolic process | 59/7958 | 100/18723 | 6.35e-04 | 3.93e-03 | 59 |
| GO:000663911 | Liver | HCC | acylglycerol metabolic process | 72/7958 | 128/18723 | 1.16e-03 | 6.54e-03 | 72 |
| GO:000663811 | Liver | HCC | neutral lipid metabolic process | 72/7958 | 129/18723 | 1.54e-03 | 8.14e-03 | 72 |
| GO:00461642 | Liver | HCC | alcohol catabolic process | 33/7958 | 55/18723 | 6.63e-03 | 2.69e-02 | 33 |
| GO:0052646 | Liver | HCC | alditol phosphate metabolic process | 9/7958 | 11/18723 | 9.51e-03 | 3.60e-02 | 9 |
| GO:00160529 | Prostate | BPH | carbohydrate catabolic process | 40/3107 | 154/18723 | 2.00e-03 | 1.13e-02 | 40 |
| GO:00442624 | Prostate | BPH | cellular carbohydrate metabolic process | 66/3107 | 283/18723 | 2.06e-03 | 1.16e-02 | 66 |
| GO:0044275 | Prostate | BPH | cellular carbohydrate catabolic process | 13/3107 | 40/18723 | 1.01e-02 | 4.25e-02 | 13 |
| GO:001605214 | Prostate | Tumor | carbohydrate catabolic process | 42/3246 | 154/18723 | 1.35e-03 | 8.44e-03 | 42 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GK5 | SNV | Missense_Mutation | rs771868963 | c.716N>T | p.Ser239Leu | p.S239L | Q6ZS86 | protein_coding | deleterious(0.01) | possibly_damaging(0.503) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GK5 | SNV | Missense_Mutation | c.1264N>C | p.Glu422Gln | p.E422Q | Q6ZS86 | protein_coding | tolerated(0.11) | benign(0.314) | TCGA-E2-A14R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
| GK5 | insertion | Nonsense_Mutation | novel | c.251_252insTGTCTTGTTCTATGTTATAAATTAATGATGCCACTTTC | p.Gln85ValfsTer8 | p.Q85Vfs*8 | Q6ZS86 | protein_coding | TCGA-A8-A0A1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| GK5 | insertion | Frame_Shift_Ins | novel | c.1477_1478insTTTTGTTTTTGCTGTC | p.Arg493IlefsTer9 | p.R493Ifs*9 | Q6ZS86 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| GK5 | insertion | Frame_Shift_Ins | novel | c.1476_1477insGAGAGATTTATAGAGA | p.Arg493GlufsTer9 | p.R493Efs*9 | Q6ZS86 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| GK5 | SNV | Missense_Mutation | c.1357G>T | p.Asp453Tyr | p.D453Y | Q6ZS86 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| GK5 | SNV | Missense_Mutation | rs377316725 | c.985N>A | p.Val329Ile | p.V329I | Q6ZS86 | protein_coding | tolerated(0.15) | benign(0.053) | TCGA-C5-A1M9-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
| GK5 | SNV | Missense_Mutation | novel | c.707N>T | p.Ser236Phe | p.S236F | Q6ZS86 | protein_coding | tolerated(0.31) | benign(0.021) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| GK5 | SNV | Missense_Mutation | c.326N>A | p.Gly109Glu | p.G109E | Q6ZS86 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| GK5 | SNV | Missense_Mutation | c.740N>A | p.Pro247His | p.P247H | Q6ZS86 | protein_coding | deleterious(0.02) | possibly_damaging(0.852) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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