Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: GJB3

Gene summary for GJB3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

GJB3

Gene ID

2707

Gene namegap junction protein beta 3
Gene AliasCX31
Cytomap1p34.3
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

O75712


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
2707GJB3TumorHumanCervixCC1.27e-214.92e-010.1241
2707GJB3sample3HumanCervixCC1.51e-356.04e-010.1387
2707GJB3T1HumanCervixCC1.36e-022.57e-010.0918
2707GJB3T3HumanCervixCC2.42e-336.11e-010.1389
2707GJB3HTA11_2487_2000001011HumanColorectumSER5.91e-123.97e-01-0.1808
2707GJB3HTA11_1938_2000001011HumanColorectumAD7.73e-093.35e-01-0.0811
2707GJB3HTA11_347_2000001011HumanColorectumAD1.42e-071.68e-01-0.1954
2707GJB3HTA11_411_2000001011HumanColorectumSER1.20e-077.13e-01-0.2602
2707GJB3HTA11_696_2000001011HumanColorectumAD3.61e-028.02e-02-0.1464
2707GJB3HTA11_1391_2000001011HumanColorectumAD7.96e-092.56e-01-0.059
2707GJB3HTA11_5212_2000001011HumanColorectumAD5.12e-052.75e-01-0.2061
2707GJB3HTA11_6818_2000001021HumanColorectumAD2.64e-032.01e-010.0588
2707GJB3HTA11_99999971662_82457HumanColorectumMSS9.04e-051.50e-010.3859
2707GJB3LZE4THumanEsophagusESCC7.81e-10-1.34e-010.0811
2707GJB3LZE7THumanEsophagusESCC3.19e-07-9.23e-020.0667
2707GJB3LZE8THumanEsophagusESCC5.44e-03-6.94e-020.067
2707GJB3LZE6THumanEsophagusESCC4.24e-02-2.88e-010.0845
2707GJB3P4T-EHumanEsophagusESCC4.99e-069.97e-020.1323
2707GJB3P5T-EHumanEsophagusESCC2.56e-083.25e-010.1327
2707GJB3P8T-EHumanEsophagusESCC3.65e-148.06e-030.0889
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00435884CervixCCskin development71/2311263/187238.04e-111.46e-0871
GO:00018908CervixCCplacenta development40/2311144/187234.59e-071.77e-0540
GO:00614588CervixCCreproductive system development87/2311427/187231.37e-064.55e-0587
GO:00486088CervixCCreproductive structure development86/2311424/187231.90e-065.97e-0586
GO:00017018CervixCCin utero embryonic development71/2311367/187237.21e-051.00e-0371
GO:0001701ColorectumADin utero embryonic development110/3918367/187232.36e-054.62e-04110
GO:0001890ColorectumADplacenta development51/3918144/187233.99e-057.16e-0451
GO:0061458ColorectumADreproductive system development116/3918427/187231.11e-031.01e-02116
GO:0048608ColorectumADreproductive structure development114/3918424/187231.78e-031.47e-02114
GO:00018901ColorectumSERplacenta development43/2897144/187239.10e-063.03e-0443
GO:00017011ColorectumSERin utero embryonic development77/2897367/187232.77e-032.48e-0277
GO:00614581ColorectumSERreproductive system development87/2897427/187233.69e-033.07e-0287
GO:00486081ColorectumSERreproductive structure development85/2897424/187236.33e-034.56e-0285
GO:00018902ColorectumMSSplacenta development51/3467144/187231.10e-063.77e-0551
GO:00614582ColorectumMSSreproductive system development115/3467427/187239.86e-062.39e-04115
GO:00486082ColorectumMSSreproductive structure development113/3467424/187231.94e-054.18e-04113
GO:00017012ColorectumMSSin utero embryonic development99/3467367/187233.71e-057.10e-0499
GO:000170119EsophagusESCCin utero embryonic development243/8552367/187231.00e-156.86e-14243
GO:0001890110EsophagusESCCplacenta development98/8552144/187234.46e-088.11e-0798
GO:00435888EsophagusESCCskin development163/8552263/187236.48e-081.14e-06163
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
GJB3SNVMissense_Mutationrs763321092c.697N>Ap.Ala233Thrp.A233TO75712protein_codingtolerated(0.62)benign(0)TCGA-AN-A049-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
GJB3SNVMissense_Mutationrs147106166c.316N>Tp.Arg106Cysp.R106CO75712protein_codingdeleterious(0.02)probably_damaging(0.959)TCGA-D8-A1XZ-01Breastbreast invasive carcinomaFemale>=65III/IVHormone Therapytamoxiphen+anastrozolumSD
GJB3SNVMissense_Mutationrs796807027c.280N>Ap.His94Asnp.H94NO75712protein_codingdeleterious(0)probably_damaging(1)TCGA-E2-A1IN-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
GJB3SNVMissense_Mutationnovelc.470A>Gp.Asn157Serp.N157SO75712protein_codingtolerated(0.52)benign(0.003)TCGA-E9-A2JS-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycyclophosphamidePD
GJB3deletionFrame_Shift_Delc.131_132delNNp.Asp46Terp.D46*O75712protein_codingTCGA-BH-A0HA-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
GJB3SNVMissense_Mutationrs369979083c.317N>Ap.Arg106Hisp.R106HO75712protein_codingtolerated(0.07)benign(0.141)TCGA-AA-3811-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownPD
GJB3SNVMissense_Mutationc.124C>Tp.Arg42Cysp.R42CO75712protein_codingdeleterious(0)probably_damaging(0.93)TCGA-AA-A022-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
GJB3SNVMissense_Mutationnovelc.455N>Ap.Leu152Hisp.L152HO75712protein_codingdeleterious(0)probably_damaging(0.98)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
GJB3SNVMissense_Mutationc.124N>Tp.Arg42Cysp.R42CO75712protein_codingdeleterious(0)probably_damaging(0.93)TCGA-D5-6930-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
GJB3SNVMissense_Mutationrs759759043c.478N>Tp.Arg160Cysp.R160CO75712protein_codingdeleterious(0.02)probably_damaging(0.923)TCGA-F4-6806-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyirinotecanPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
2707GJB3TRANSPORTER, ION CHANNELinhibitor178101095OCTANOL
2707GJB3TRANSPORTER, ION CHANNELinhibitor178100972CARBENOXOLONE
2707GJB3TRANSPORTER, ION CHANNELinhibitor135650269
2707GJB3TRANSPORTER, ION CHANNELinhibitor135652731
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