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Gene: GIMAP1 |
Gene summary for GIMAP1 |
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Gene information | Species | Human | Gene symbol | GIMAP1 | Gene ID | 170575 |
Gene name | GTPase, IMAP family member 1 | |
Gene Alias | HIMAP1 | |
Cytomap | 7q36.1 | |
Gene Type | protein-coding | GO ID | GO:0000139 | UniProtAcc | A0A090N8Z4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
170575 | GIMAP1 | HCC1 | Human | Liver | HCC | 7.71e-06 | 6.45e-01 | 0.5336 |
170575 | GIMAP1 | HCC2 | Human | Liver | HCC | 7.36e-09 | 7.62e-01 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GIMAP1 | SNV | Missense_Mutation | c.545N>T | p.Gly182Val | p.G182V | Q8WWP7 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GIMAP1 | SNV | Missense_Mutation | c.232N>A | p.Val78Met | p.V78M | Q8WWP7 | protein_coding | tolerated(0.29) | possibly_damaging(0.904) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
GIMAP1 | SNV | Missense_Mutation | rs537240577 | c.722N>A | p.Arg241Gln | p.R241Q | Q8WWP7 | protein_coding | tolerated(0.18) | benign(0.01) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GIMAP1 | SNV | Missense_Mutation | c.319C>A | p.Leu107Ile | p.L107I | Q8WWP7 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GIMAP1 | SNV | Missense_Mutation | c.584N>A | p.Arg195Gln | p.R195Q | Q8WWP7 | protein_coding | tolerated(0.5) | benign(0.019) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GIMAP1 | SNV | Missense_Mutation | c.417C>A | p.Phe139Leu | p.F139L | Q8WWP7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-2679-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GIMAP1 | SNV | Missense_Mutation | rs374968861 | c.376N>A | p.Ala126Thr | p.A126T | Q8WWP7 | protein_coding | tolerated(0.52) | benign(0.036) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GIMAP1 | SNV | Missense_Mutation | rs780854861 | c.617G>A | p.Gly206Glu | p.G206E | Q8WWP7 | protein_coding | tolerated(1) | benign(0.03) | TCGA-AA-3982-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
GIMAP1 | SNV | Missense_Mutation | rs752300708 | c.898N>A | p.Val300Ile | p.V300I | Q8WWP7 | protein_coding | tolerated_low_confidence(0.76) | benign(0.005) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
GIMAP1 | SNV | Missense_Mutation | c.583C>T | p.Arg195Trp | p.R195W | Q8WWP7 | protein_coding | deleterious(0.02) | benign(0.148) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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