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Gene: GFUS |
Gene summary for GFUS |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GFUS | Gene ID | 7264 |
| Gene name | GDP-L-fucose synthase | |
| Gene Alias | FX | |
| Cytomap | 8q24.3 | |
| Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | Q13630 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7264 | GFUS | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.98e-03 | 9.73e-02 | 0.0155 |
| 7264 | GFUS | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.63e-22 | 6.47e-01 | -0.1808 |
| 7264 | GFUS | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.92e-17 | 4.70e-01 | -0.0811 |
| 7264 | GFUS | HTA11_78_2000001011 | Human | Colorectum | AD | 7.85e-13 | 3.59e-01 | -0.1088 |
| 7264 | GFUS | HTA11_347_2000001011 | Human | Colorectum | AD | 2.51e-09 | 2.05e-01 | -0.1954 |
| 7264 | GFUS | HTA11_411_2000001011 | Human | Colorectum | SER | 6.89e-14 | 7.74e-01 | -0.2602 |
| 7264 | GFUS | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.75e-12 | 7.06e-01 | -0.2196 |
| 7264 | GFUS | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.26e-13 | 4.47e-01 | -0.1207 |
| 7264 | GFUS | HTA11_83_2000001011 | Human | Colorectum | SER | 1.79e-04 | 2.04e-01 | -0.1526 |
| 7264 | GFUS | HTA11_696_2000001011 | Human | Colorectum | AD | 3.49e-32 | 6.21e-01 | -0.1464 |
| 7264 | GFUS | HTA11_866_2000001011 | Human | Colorectum | AD | 4.46e-07 | 2.13e-01 | -0.1001 |
| 7264 | GFUS | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.00e-27 | 7.20e-01 | -0.059 |
| 7264 | GFUS | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.29e-03 | 2.14e-01 | -0.1706 |
| 7264 | GFUS | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-02 | 3.36e-01 | -0.1462 |
| 7264 | GFUS | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-08 | 3.33e-01 | -0.0842 |
| 7264 | GFUS | HTA11_866_3004761011 | Human | Colorectum | AD | 1.36e-07 | 1.83e-01 | 0.096 |
| 7264 | GFUS | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.36e-01 | 0.0446 |
| 7264 | GFUS | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.19e-02 | 2.26e-01 | 0.0528 |
| 7264 | GFUS | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.81e-04 | 2.31e-01 | 0.0131 |
| 7264 | GFUS | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.98e-03 | 1.87e-01 | -0.0177 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
| GO:0022900 | Colorectum | AD | electron transport chain | 89/3918 | 175/18723 | 1.42e-18 | 8.91e-16 | 89 |
| GO:0010811 | Colorectum | AD | positive regulation of cell-substrate adhesion | 53/3918 | 123/18723 | 2.30e-08 | 1.27e-06 | 53 |
| GO:0010810 | Colorectum | AD | regulation of cell-substrate adhesion | 81/3918 | 221/18723 | 4.80e-08 | 2.55e-06 | 81 |
| GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
| GO:0001952 | Colorectum | AD | regulation of cell-matrix adhesion | 50/3918 | 128/18723 | 2.05e-06 | 6.05e-05 | 50 |
| GO:0001954 | Colorectum | AD | positive regulation of cell-matrix adhesion | 27/3918 | 58/18723 | 1.12e-05 | 2.55e-04 | 27 |
| GO:0001667 | Colorectum | AD | ameboidal-type cell migration | 137/3918 | 475/18723 | 2.17e-05 | 4.33e-04 | 137 |
| GO:0007160 | Colorectum | AD | cell-matrix adhesion | 75/3918 | 233/18723 | 3.56e-05 | 6.45e-04 | 75 |
| GO:0090132 | Colorectum | AD | epithelium migration | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
| GO:0010632 | Colorectum | AD | regulation of epithelial cell migration | 88/3918 | 292/18723 | 1.19e-04 | 1.75e-03 | 88 |
| GO:0010631 | Colorectum | AD | epithelial cell migration | 104/3918 | 357/18723 | 1.33e-04 | 1.90e-03 | 104 |
| GO:0090130 | Colorectum | AD | tissue migration | 105/3918 | 365/18723 | 2.10e-04 | 2.77e-03 | 105 |
| GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
| GO:0010634 | Colorectum | AD | positive regulation of epithelial cell migration | 56/3918 | 176/18723 | 4.51e-04 | 5.03e-03 | 56 |
| GO:0009225 | Colorectum | AD | nucleotide-sugar metabolic process | 16/3918 | 36/18723 | 1.27e-03 | 1.12e-02 | 16 |
| GO:0043542 | Colorectum | AD | endothelial cell migration | 78/3918 | 279/18723 | 2.97e-03 | 2.22e-02 | 78 |
| GO:0010595 | Colorectum | AD | positive regulation of endothelial cell migration | 40/3918 | 133/18723 | 8.01e-03 | 4.73e-02 | 40 |
| GO:00060911 | Colorectum | SER | generation of precursor metabolites and energy | 168/2897 | 490/18723 | 1.39e-25 | 1.70e-22 | 168 |
| GO:00229001 | Colorectum | SER | electron transport chain | 77/2897 | 175/18723 | 1.77e-19 | 1.36e-16 | 77 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa00051 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
| hsa000511 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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