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Gene: GET3 |
Gene summary for GET3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GET3 | Gene ID | 439 |
| Gene name | guided entry of tail-anchored proteins factor 3, ATPase | |
| Gene Alias | ARSA-I | |
| Cytomap | 19p13.13 | |
| Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | O43681 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 439 | GET3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.30e-05 | 1.39e-01 | 0.0155 |
| 439 | GET3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.31e-21 | 4.84e-01 | -0.1808 |
| 439 | GET3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.34e-04 | 2.80e-01 | 0.0216 |
| 439 | GET3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.83e-13 | 3.71e-01 | -0.0811 |
| 439 | GET3 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.42e-13 | 2.98e-01 | -0.1088 |
| 439 | GET3 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.41e-19 | 3.80e-01 | -0.1954 |
| 439 | GET3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.35e-12 | 7.46e-01 | -0.2602 |
| 439 | GET3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.29e-05 | 3.37e-01 | -0.2196 |
| 439 | GET3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.26e-09 | 2.78e-01 | -0.1207 |
| 439 | GET3 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.79e-04 | 2.45e-01 | -0.1526 |
| 439 | GET3 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.20e-20 | 3.40e-01 | -0.1464 |
| 439 | GET3 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.46e-07 | 1.77e-01 | -0.1001 |
| 439 | GET3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.56e-17 | 4.20e-01 | -0.059 |
| 439 | GET3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.94e-06 | 3.56e-01 | -0.1706 |
| 439 | GET3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.12e-05 | 2.80e-01 | -0.2061 |
| 439 | GET3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.17e-09 | 4.66e-01 | -0.1462 |
| 439 | GET3 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.17e-02 | 1.84e-01 | -0.0842 |
| 439 | GET3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.96e-03 | 2.16e-01 | -0.0179 |
| 439 | GET3 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.05e-12 | 2.93e-01 | 0.096 |
| 439 | GET3 | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.79e-04 | 2.70e-01 | 0.0451 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
| GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
| GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
| GO:0051205 | Colorectum | AD | protein insertion into membrane | 23/3918 | 57/18723 | 6.62e-04 | 6.80e-03 | 23 |
| GO:0007029 | Colorectum | AD | endoplasmic reticulum organization | 31/3918 | 87/18723 | 1.08e-03 | 1.00e-02 | 31 |
| GO:0070972 | Colorectum | AD | protein localization to endoplasmic reticulum | 26/3918 | 74/18723 | 3.28e-03 | 2.40e-02 | 26 |
| GO:0006620 | Colorectum | AD | posttranslational protein targeting to endoplasmic reticulum membrane | 7/3918 | 12/18723 | 5.09e-03 | 3.38e-02 | 7 |
| GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
| GO:00725941 | Colorectum | SER | establishment of protein localization to organelle | 111/2897 | 422/18723 | 4.98e-09 | 4.49e-07 | 111 |
| GO:00901501 | Colorectum | SER | establishment of protein localization to membrane | 68/2897 | 260/18723 | 5.55e-06 | 2.01e-04 | 68 |
| GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
| GO:00512051 | Colorectum | SER | protein insertion into membrane | 19/2897 | 57/18723 | 6.32e-04 | 8.58e-03 | 19 |
| GO:00066201 | Colorectum | SER | posttranslational protein targeting to endoplasmic reticulum membrane | 6/2897 | 12/18723 | 5.42e-03 | 4.03e-02 | 6 |
| GO:00070291 | Colorectum | SER | endoplasmic reticulum organization | 23/2897 | 87/18723 | 5.77e-03 | 4.23e-02 | 23 |
| GO:007259420 | Esophagus | HGIN | establishment of protein localization to organelle | 120/2587 | 422/18723 | 1.73e-15 | 4.00e-13 | 120 |
| GO:000660525 | Esophagus | HGIN | protein targeting | 78/2587 | 314/18723 | 1.08e-07 | 5.47e-06 | 78 |
| GO:009015020 | Esophagus | HGIN | establishment of protein localization to membrane | 67/2587 | 260/18723 | 1.96e-07 | 9.57e-06 | 67 |
| GO:007097210 | Esophagus | HGIN | protein localization to endoplasmic reticulum | 26/2587 | 74/18723 | 3.09e-06 | 1.05e-04 | 26 |
| GO:00512057 | Esophagus | HGIN | protein insertion into membrane | 21/2587 | 57/18723 | 1.16e-05 | 3.29e-04 | 21 |
| GO:00725999 | Esophagus | HGIN | establishment of protein localization to endoplasmic reticulum | 16/2587 | 46/18723 | 2.73e-04 | 4.71e-03 | 16 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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