![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GEMIN4 |
Gene summary for GEMIN4 |
![]() |
Gene information | Species | Human | Gene symbol | GEMIN4 | Gene ID | 50628 |
Gene name | gem nuclear organelle associated protein 4 | |
Gene Alias | HC56 | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P57678 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50628 | GEMIN4 | LZE7T | Human | Esophagus | ESCC | 3.24e-02 | 2.15e-01 | 0.0667 |
50628 | GEMIN4 | LZE24T | Human | Esophagus | ESCC | 1.14e-06 | 1.74e-01 | 0.0596 |
50628 | GEMIN4 | P2T-E | Human | Esophagus | ESCC | 8.91e-12 | 2.28e-01 | 0.1177 |
50628 | GEMIN4 | P4T-E | Human | Esophagus | ESCC | 2.54e-05 | 1.18e-01 | 0.1323 |
50628 | GEMIN4 | P8T-E | Human | Esophagus | ESCC | 1.89e-05 | 7.89e-02 | 0.0889 |
50628 | GEMIN4 | P9T-E | Human | Esophagus | ESCC | 2.80e-05 | 9.71e-02 | 0.1131 |
50628 | GEMIN4 | P10T-E | Human | Esophagus | ESCC | 2.11e-08 | 7.29e-02 | 0.116 |
50628 | GEMIN4 | P11T-E | Human | Esophagus | ESCC | 1.05e-02 | 1.70e-01 | 0.1426 |
50628 | GEMIN4 | P12T-E | Human | Esophagus | ESCC | 1.58e-11 | 1.27e-01 | 0.1122 |
50628 | GEMIN4 | P15T-E | Human | Esophagus | ESCC | 4.23e-04 | 1.06e-01 | 0.1149 |
50628 | GEMIN4 | P16T-E | Human | Esophagus | ESCC | 1.19e-13 | 2.58e-01 | 0.1153 |
50628 | GEMIN4 | P17T-E | Human | Esophagus | ESCC | 5.30e-03 | 2.63e-01 | 0.1278 |
50628 | GEMIN4 | P20T-E | Human | Esophagus | ESCC | 2.13e-05 | 1.44e-01 | 0.1124 |
50628 | GEMIN4 | P21T-E | Human | Esophagus | ESCC | 9.08e-10 | 1.79e-01 | 0.1617 |
50628 | GEMIN4 | P22T-E | Human | Esophagus | ESCC | 3.79e-11 | 1.01e-01 | 0.1236 |
50628 | GEMIN4 | P23T-E | Human | Esophagus | ESCC | 4.48e-17 | 3.79e-01 | 0.108 |
50628 | GEMIN4 | P24T-E | Human | Esophagus | ESCC | 1.82e-08 | 2.54e-01 | 0.1287 |
50628 | GEMIN4 | P26T-E | Human | Esophagus | ESCC | 1.42e-14 | 1.31e-01 | 0.1276 |
50628 | GEMIN4 | P27T-E | Human | Esophagus | ESCC | 1.74e-06 | 8.02e-02 | 0.1055 |
50628 | GEMIN4 | P28T-E | Human | Esophagus | ESCC | 1.95e-09 | 1.86e-01 | 0.1149 |
Page: 1 2 3 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0071826111 | Esophagus | ESCC | ribonucleoprotein complex subunit organization | 166/8552 | 227/18723 | 2.94e-17 | 2.42e-15 | 166 |
GO:0022618111 | Esophagus | ESCC | ribonucleoprotein complex assembly | 159/8552 | 220/18723 | 8.19e-16 | 5.71e-14 | 159 |
GO:00003875 | Esophagus | ESCC | spliceosomal snRNP assembly | 32/8552 | 50/18723 | 6.90e-03 | 2.52e-02 | 32 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GEMIN4 | SNV | Missense_Mutation | rs753597687 | c.2081N>T | p.Pro694Leu | p.P694L | P57678 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GEMIN4 | SNV | Missense_Mutation | c.898N>A | p.Val300Ile | p.V300I | P57678 | protein_coding | tolerated(0.32) | benign(0.01) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GEMIN4 | SNV | Missense_Mutation | c.1705N>T | p.Val569Leu | p.V569L | P57678 | protein_coding | deleterious(0.01) | benign(0.341) | TCGA-D8-A1JP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
GEMIN4 | SNV | Missense_Mutation | rs373337995 | c.448N>A | p.Val150Ile | p.V150I | P57678 | protein_coding | tolerated(0.21) | benign(0) | TCGA-E2-A1BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
GEMIN4 | SNV | Missense_Mutation | novel | c.1510C>T | p.Arg504Cys | p.R504C | P57678 | protein_coding | deleterious(0.04) | benign(0.172) | TCGA-LL-A5YP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
GEMIN4 | insertion | In_Frame_Ins | novel | c.875_876insCCTGTCTCTACAAAAAGAAAAAAAAATGAGTTTAAG | p.Lys292delinsAsnLeuSerLeuGlnLysGluLysLysMetSerLeuArg | p.K292delinsNLSLQKEKKMSLR | P57678 | protein_coding | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
GEMIN4 | insertion | In_Frame_Ins | novel | c.1471_1472insGGATGA | p.Ser491delinsTrpMetThr | p.S491delinsWMT | P57678 | protein_coding | TCGA-AN-A041-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GEMIN4 | insertion | Frame_Shift_Ins | novel | c.2295_2296insAGGCTGAGGCAGGAGAATCGCTTGAACC | p.Leu766ArgfsTer29 | p.L766Rfs*29 | P57678 | protein_coding | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GEMIN4 | insertion | Nonsense_Mutation | novel | c.1805_1806insTGCAAATAGGGCAAGTTAGAAGAAGGAGGTAATATGA | p.Met603AlafsTer6 | p.M603Afs*6 | P57678 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GEMIN4 | SNV | Missense_Mutation | novel | c.871N>A | p.Glu291Lys | p.E291K | P57678 | protein_coding | deleterious(0.01) | possibly_damaging(0.642) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |