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Gene: GDA |
Gene summary for GDA |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GDA | Gene ID | 9615 |
| Gene name | guanine deaminase | |
| Gene Alias | CYPIN | |
| Cytomap | 9q21.13 | |
| Gene Type | protein-coding | GO ID | GO:0000255 | UniProtAcc | Q9Y2T3 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9615 | GDA | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.29e-09 | 8.87e-01 | -0.1808 |
| 9615 | GDA | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.58e-03 | 2.69e-01 | -0.0811 |
| 9615 | GDA | HTA11_78_2000001011 | Human | Colorectum | AD | 6.31e-04 | 3.51e-01 | -0.1088 |
| 9615 | GDA | HTA11_347_2000001011 | Human | Colorectum | AD | 6.06e-04 | 4.83e-01 | -0.1954 |
| 9615 | GDA | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.70e-02 | 8.18e-01 | -0.2196 |
| 9615 | GDA | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.34e-03 | 4.75e-01 | -0.059 |
| 9615 | GDA | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.59e-05 | 1.43e+00 | 0.3487 |
| 9615 | GDA | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.13e-02 | 2.27e-01 | 0.281 |
| 9615 | GDA | CRC-1-8810 | Human | Colorectum | CRC | 7.56e-05 | 3.50e-01 | 0.6257 |
| 9615 | GDA | AEH-subject1 | Human | Endometrium | AEH | 3.00e-11 | 5.37e-01 | -0.3059 |
| 9615 | GDA | AEH-subject2 | Human | Endometrium | AEH | 9.63e-22 | 7.05e-01 | -0.2525 |
| 9615 | GDA | AEH-subject3 | Human | Endometrium | AEH | 4.70e-02 | 2.50e-01 | -0.2576 |
| 9615 | GDA | AEH-subject4 | Human | Endometrium | AEH | 6.96e-08 | 4.00e-01 | -0.2657 |
| 9615 | GDA | AEH-subject5 | Human | Endometrium | AEH | 4.57e-11 | 6.02e-01 | -0.2953 |
| 9615 | GDA | EEC-subject2 | Human | Endometrium | EEC | 3.15e-25 | 7.45e-01 | -0.2607 |
| 9615 | GDA | EEC-subject5 | Human | Endometrium | EEC | 5.10e-13 | 5.55e-01 | -0.249 |
| 9615 | GDA | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.17e-02 | 1.92e-01 | -0.1934 |
| 9615 | GDA | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 5.00e-11 | 4.51e-01 | -0.1917 |
| 9615 | GDA | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.10e-10 | 4.95e-01 | -0.1916 |
| 9615 | GDA | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.01e-13 | 4.31e-01 | -0.1269 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
| GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
| GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
| GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
| GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
| GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
| GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
| GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
| GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
| GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
| GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
| GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
| GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
| GO:0009126 | Colorectum | AD | purine nucleoside monophosphate metabolic process | 19/3918 | 44/18723 | 7.13e-04 | 7.21e-03 | 19 |
| GO:0009167 | Colorectum | AD | purine ribonucleoside monophosphate metabolic process | 18/3918 | 41/18723 | 7.71e-04 | 7.73e-03 | 18 |
| GO:0046037 | Colorectum | AD | GMP metabolic process | 9/3918 | 16/18723 | 2.06e-03 | 1.64e-02 | 9 |
| GO:0006195 | Colorectum | AD | purine nucleotide catabolic process | 18/3918 | 46/18723 | 3.67e-03 | 2.60e-02 | 18 |
| GO:0072523 | Colorectum | AD | purine-containing compound catabolic process | 19/3918 | 52/18723 | 6.92e-03 | 4.26e-02 | 19 |
| GO:00061631 | Colorectum | SER | purine nucleotide metabolic process | 109/2897 | 396/18723 | 4.26e-10 | 5.44e-08 | 109 |
| GO:00091501 | Colorectum | SER | purine ribonucleotide metabolic process | 103/2897 | 368/18723 | 4.69e-10 | 5.68e-08 | 103 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
| hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
| hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
| hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GDA | SNV | Missense_Mutation | novel | c.311N>G | p.Thr104Ser | p.T104S | Q9Y2T3 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-A2-A0D0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
| GDA | SNV | Missense_Mutation | c.666N>C | p.Leu222Phe | p.L222F | Q9Y2T3 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| GDA | SNV | Missense_Mutation | novel | c.448N>C | p.Ser150Pro | p.S150P | Q9Y2T3 | protein_coding | deleterious(0.02) | possibly_damaging(0.749) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| GDA | SNV | Missense_Mutation | c.352N>A | p.Asp118Asn | p.D118N | Q9Y2T3 | protein_coding | tolerated(0.11) | benign(0.006) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| GDA | SNV | Missense_Mutation | rs748443792 | c.895N>A | p.Ala299Thr | p.A299T | Q9Y2T3 | protein_coding | tolerated(0.19) | possibly_damaging(0.446) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| GDA | SNV | Missense_Mutation | c.574G>A | p.Glu192Lys | p.E192K | Q9Y2T3 | protein_coding | tolerated(0.61) | benign(0.001) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
| GDA | SNV | Missense_Mutation | c.361N>A | p.Glu121Lys | p.E121K | Q9Y2T3 | protein_coding | tolerated(0.39) | benign(0.023) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| GDA | SNV | Missense_Mutation | c.148N>G | p.Gln50Glu | p.Q50E | Q9Y2T3 | protein_coding | tolerated(0.37) | benign(0) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| GDA | SNV | Missense_Mutation | c.738N>G | p.Asp246Glu | p.D246E | Q9Y2T3 | protein_coding | tolerated(0.69) | benign(0) | TCGA-CM-6676-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| GDA | SNV | Missense_Mutation | c.74C>A | p.Pro25His | p.P25H | Q9Y2T3 | protein_coding | tolerated(0.22) | benign(0.029) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
| Page: 1 2 3 4 5 6 7 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 9615 | GDA | ENZYME | NSC-7861 | 7-METHYLXANTHINE | 20716488 | |
| 9615 | GDA | ENZYME | 8-AZAGUANINE | 8-AZAGUANINE | 7384171 | |
| 9615 | GDA | ENZYME | THIOGUANINE | THIOGUANINE | 7384171 |
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